4 research outputs found

    Open is as open does. How to use open content in a personalized interactive museum exhibit

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    Open is as open does. Open content has been a hot topic in heritage for several years. The Netherlands Institute for Sound and Vision has long been a front runner when it comes to supporting open standards and free re-use of our collections. Surprisingly enough, we never tried it the other way around: using open content to create an exhibit. So when we started to develop an exhibition celebrating the 50th anniversary of 3FM - one of Holland’s main public pop radio channels - we asked ourselves: would we be able to create a personalized, interactive videomapping exhibit using mainly open content? During a How-To-Session Karen Drost and Maarten Brinkerink will dive into how we managed this, and share what we learned

    A highly virulent variant of HIV-1 circulating in the Netherlands

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    We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV-CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences-is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence

    Children living with HIV in Europe: do migrants have worse treatment outcomes?

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    International audienceTo assess the effect of migrant status on treatment outcomes among children living with HIV in Europe
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