Comparative analysis of co-processed starches prepared by three different methods

Co-processing is currently of interest in the generation of high-functionality excipients for tablet formulation. In the present study, comparative analysis of the powder and tableting properties of three co-processed starches prepared by three different methods was carried out. The co-processed excipients consisting of maize starch (90%), acacia gum (7.5%) and colloidal silicon dioxide (2.5%) were prepared by co-dispersion (SAS-CD), co-fusion (SAS-CF) and co-granulation (SAS-CG). Powder properties of each co-processed excipient were characterized by measuring particle size, flow indices, particle density, dilution potential and lubricant sensitivity ratio. Heckel and Walker models were used to evaluate the compaction behaviour of the three co-processed starches. Tablets were produced with paracetamol as the model drug by direct compression on an eccentric Tablet Press fitted with 12 mm flat-faced punches and compressed at 216 MPa. The tablets were stored at room temperature for 24 h prior to evaluation. The results revealed that co-granulated co-processed excipient (SAS-CG) gave relatively better properties in terms of flow, compressibility, dilution potential, deformation, disintegration, crushing strength and friability. This study has shown that the method of co-processing influences the powder and tableting properties of the co-processed excipient

Comparative analysis of co-processed starches prepared by three different methods

Co-processing is currently of interest in the generation of high-functionality excipients for tablet formulation. In the present study, comparative analysis of the powder and tableting properties of three co-processed starches prepared by three different methods was carried out. The co-processed excipients consisting of maize starch (90%), acacia gum (7.5%) and colloidal silicon dioxide (2.5%) were prepared by co-dispersion (SAS-CD), co-fusion (SAS-CF) and co-granulation (SAS-CG). Powder properties of each co-processed excipient were characterized by measuring particle size, flow indices, particle density, dilution potential and lubricant sensitivity ratio. Heckel and Walker models were used to evaluate the compaction behaviour of the three co-processed starches. Tablets were produced with paracetamol as the model drug by direct compression on an eccentric Tablet Press fitted with 12 mm flat-faced punches and compressed at 216 MPa. The tablets were stored at room temperature for 24 h prior to evaluation. The results revealed that co-granulated co-processed excipient (SAS-CG) gave relatively better properties in terms of flow, compressibility, dilution potential, deformation, disintegration, crushing strength and friability. This study has shown that the method of co-processing influences the powder and tableting properties of the co-processed excipient

Factors affecting the harmonization of disease-related metabolic brain pattern expression quantification in [18F]FDG-PET (PETMETPAT): Working Group Summaries for European Joint Programming For Neurodegenerative Research (JPND)

Introduction:The implementation of spatial-covariance [18F]fluorodeoxyglucose positron emissiontomography–based disease-related metabolic brain patterns as biomarkers has been hampered by in-tercenter imaging differences. Within the scope of the JPND-PETMETPAT working group, we illus-trate the impact of these differences on Parkinson’s disease–related pattern (PDRP) expressionscores.Methods:Five healthy controls, 5 patients with idiopathic rapid eye movement sleep behavior dis-order, and 5 patients with Parkinson’s disease were scanned on one positron emission tomography/computed tomography system with multiple image reconstructions. In addition, one Hoffman 3DBrain Phantom was scanned on several positron emission tomography/computed tomography sys-tems using various reconstructions. Effects of image contrast on PDRP scores were also examined.Results:Human and phantom raw PDRP scores were systematically influenced by scanner andreconstruction effects. PDRP scores correlated inversely to image contrast. A Gaussian spatial filterreduced contrast while decreasing intercenter score differences.Discussion:Image contrast should be considered in harmonization efforts. A Gaussian filter mayreduce noise and intercenter effects without sacrificing sensitivity. Phantom measurements will beimportant for correcting PDRP score offsets