A contingency approach to quality systems implementation

This paper describes a framework for the implementation of quality systems. It is argued that there is no one best way to implement quality systems valid for all situations. Following Galbraith, a contingency approach is presented that enables the reader to select the optimal implementation strategy for a particular situation. The approach is based on well-established organization theory and validated by the experiences of senior quality consultants.Project Management;Uncertainty;Quality;implementation;organization and management

The Genetics of Atypical Femur Fractures—a Systematic Review

Purpose of Review: Atypical femur fractures (AFFs) are rare subtrochanteric or diaphyseal fractures regarded as side effects of bisphosphonates (BPs), possibly with a genetic background. Here, we summarize the most recent knowledge about genetics of AFFs. Recent Findings: AFF has been reported in 57 patients with seven different monogenic bone disorders including hypophosphatasia and osteogenesis imperfecta; 56.1% had never used BPs, while 17.5% were diagnosed with the disorder only after the AFF. Gene mutation finding in familial and sporadic cases identified possible AFF-related variants in the GGPS1 and ATRAID genes respectively. Functional follow-up studies of mutant proteins showed possible roles in AFF. A recent small genome-wide association study on 51 AFF cases did not identify significant hits associated with AFF. Summary: Recent findings have strengthened the hypothesis that AFFs have underlying genetic components but more studies are needed in AFF families and larger cohorts of sporadic cases to confirm previous results and/or find novel gene variants involved in the pathogenesis of AFFs

The Chemical Origins of Plasma Contraction and Thermalization in CO2 Microwave Discharges

Thermalization of electron and gas temperature in CO2 microwave plasma is unveiled with the first Thomson scattering measurements. The results contradict the prevalent picture of an increasing electron temperature that causes discharge contraction. It is known that as pressure increases, the radial extension of the plasma reduces from ∼7 mm diameter at 100 mbar to ∼2 mm at 400 mbar. We find that, simultaneously, the initial nonequilibrium between ∼2 eV electron and ∼0.5 eV gas temperature reduces until thermalization occurs at 0.6 eV. 1D fluid modeling, with excellent agreement with measurements, demonstrates that associative ionization of radicals, a mechanism previously proposed for air plasma, causes the thermalization. In effect, heavy particle and heat transport and thermal chemistry govern electron dynamics, a conclusion that provides a basis for ab initio prediction of power concentration in plasma reactors

The Chemical Origins of Plasma Contraction and Thermalization in CO2 Microwave Discharges

Thermalization of electron and gas temperature in CO2 microwave plasma is unveiled with the first Thomson scattering measurements. The results contradict the prevalent picture of an increasing electron temperature that causes discharge contraction. It is known that as pressure increases, the radial extension of the plasma reduces from ∼7 mm diameter at 100 mbar to ∼2 mm at 400 mbar. We find that, simultaneously, the initial nonequilibrium between ∼2 eV electron and ∼0.5 eV gas temperature reduces until thermalization occurs at 0.6 eV. 1D fluid modeling, with excellent agreement with measurements, demonstrates that associative ionization of radicals, a mechanism previously proposed for air plasma, causes the thermalization. In effect, heavy particle and heat transport and thermal chemistry govern electron dynamics, a conclusion that provides a basis for ab initio prediction of power concentration in plasma reactors.</p

Resolving discharge parameters from atomic oxygen emission

A method is proposed to spatially resolve discharge parameters from experimental measurements of emission intensity and 1D numerical simulations including an O atom collisional-radiative model. The method can be used for different plasmas and conditions. Here, contracted microwave discharges for CO2 conversion are studied at intermediate to high pressures (100–300 mbar). Radial profiles of electron density (ne) are used as input in the model and corrected to successfully simulate the measured Gaussian profiles of emission intensity of the 777 nm transition (I777). As a result, radially-resolved parameters inaccessible in experiments, such as ne, power density (Pabs), electron temperature (Te), electric field and reaction rates, are numerically-obtained for several conditions. ne and Pabs approximately follow Gaussian profiles that are broader than that of I777. For pressures below 150 mbar, the difference in full width at half maximum is typically a factor 1.6. This consists in a phenomenon of optical contraction, which is due to concave profiles of O molar fraction and Te. The implications of the simulated profiles on the study of plasmas for CO2 conversion are discussed and it is shown that these profiles allow to explain high reactor performances at low pressures

Thermalized collisional pre-sheath detected in dense plasma with coherent and incoherent Thomson scattering

In the direct vicinity of plasma-facing surfaces, the incident plasma particles interact with surface-recombined neutrals. Remarkably high near-surface pressure losses were observed in the high-flux linear plasma generator Magnum-PSI. Combining the incoherent and coherent Thomson scattering diagnostics, we directly measured particle, momentum and energy fluxes down to 3 mm from the plasma target surface. At the surface, the particle and total heat flux were also measured, using respectively an in-target Langmuir probe and thermographic methods. The near-surface momentum and energy losses scale with density, and amount to at least 50 % and 20%, respectively, at ne=8centerdot1020m-3. These losses are attributed to the efficient exchange of charge, momentum and energy between incident plasma and surface-recombined neutrals. In low-temperature plasmas with sufficient density, incident particles go through several cycles of interaction and surface deposition before leaving the plasma, thereby providing an effective alternative dissipation channel to the incident plasma. Parallel plasma parameter profiles exhibit a transition with increasing plasma density. In low-density conditions, the plasma temperature is constant and near-surface ion acceleration is observed, attributed to the ambipolar electric field. Conversely, deceleration and plasma cooling are observed in dense conditions. These results are explained by the combined effect of ion-neutral friction and electron-ion thermal equilibration in the so-called thermalized collisional pre-sheath. The energy available for ambipolar acceleration is thus reduced, as well as the upstream flow velocity. In the ITER divertor, enhanced near-surface p-n interaction is expected as well, given the overlap in plasma conditions. Including these effects in finite-element scrape-off layer models requires a near-surface resolution smaller than the neutral mean free path. This amounts to 1 mm in Magnum-PSI, and possibly an order of magnitude smaller in ITER.</p

Suppression of tritium retention in remote areas of ITER by nonperturbative reactive gas injection

A technique based on reactive gas injection in the afterglow region of the divertor plasma is proposed for the suppression of tritium-carbon codeposits in remote areas of ITER when operated with carbon-based divertor targets. Experiments in a divertor simulator plasma device indicate that a 4¿¿nm/min deposition can be suppressed by addition of 1¿¿Pa·m3¿s-1 ammonia flow at 10 cm from the plasma. These results bolster the concept of nonperturbative scavenger injection for tritium inventory control in carbon-based fusion plasma devices, thus paving the way for ITER operation in the active phase under a carbon-dominated, plasma facing component background. © 2010 The American Physical Society

Flame bands: CO + O chemiluminescence as a measure of gas temperature

Carbon monoxide flame band emission (CO+O → CO2+hV) in CO2 microwave plasma is quantified by obtaining absolute calibrated emission spectra at various locations in the plasma afterglow while simultaneously measuring gas temperatures using rotational Raman scattering. Comparison of our results to literature reveals a contribution of O2 Schumann-Runge UV emission at T &gt; 1500 K. This UV component likely results from the collisional exchange of energy between CO2(1B) and O2. Limiting further analysis to T &lt; 1500 K, we demonstrate the utility of CO flame band emission by analyzing afterglows at different plasma conditions. We show that the highest energy efficiency for CO production coincides with an operating condition where very little heat has been lost to the environment prior to ∼3 cm downstream, while simultaneously, T ends up below the level required to effectively freeze in CO. This observation demonstrates that, in CO2 plasma conversion, optimizing for energy efficiency does not require a sophisticated downstream cooling method.</p

Fauna in het rivierengebied : uitkomsten fase 1: knelpunten en mogelijkheden voor herstel van terrestrische en amfibische fauna

De studie richt zich op het maken van een analyse van de belangrijkste knelpunten voor karakteristieke terrestrische en amfibische fauna in het rivierengebied en de mogelijkheden te verkennen voor het opheffen van deze knelpunten binnen de huidige randvoorwaarden van het Nederlandse rivieren-gebied. Deze kennis vormt de basis voor de beheersadviezen die OBN geeft voor optimalisatie van herstel en behoud van de biodiversiteit in het rivieren-gebied. De studie kijkt met een bredere blik naar bestaande gegevens en kennis, om een (wetenschappelijke) onderbouwing te geven van bekende verklaringen van knelpunten, of sommige verklaringen te ontkrachten. De meerwaarde van deze aanpak ten opzichte van eerdere studies ligt vooral in de algemene toepassing van de resultaten en de analyse op een hoger schaalniveau