Leucocyte grouping : a method and its application

This study describes the development of a method for the recognition and definition of leucocyte group Four. The method can also be applied to the detection of other leucocyte groups. Essential factors in the method were: a) the use of leucocyte agglutinins formed during pregnancy; b) an insight into the shortcomings of the agglutination test; c) the use of statistical methods to overcome these shortcomings; and d) the use of a panel consisting of the leucocytes of the women who had formed the agglutinins, and of those of their husbands.                                                      This study describes the development of a method for the recognition and definition of leucocyte group Four. The method can also be applied to the detection of other leucocyte groups. Essential factors in the method were: a) the use of leucocyte agglutinins formed during pregnancy; b) an insight into the shortcomings of the agglutination test; c) the use of statistical methods to overcome these shortcomings; and d) the use of a panel consisting of the leucocytes of the women who had formed the agglutinins, and of those of their husbands.      LUMC / Geneeskund