Clinical Impact of Viability guided Angioplasty after Acute Myocardial Infarction: The VIAMI trial

Rossum, A.C. van [Promotor]Veen, G. [Copromotor

I spy with my MRI: Cause of complete heart block in a young patient revealed

Contains fulltext : 177038.pdf (publisher's version ) (Open Access

Altered awareness in patients with Korsakoff syndrome living in long-term care facilities; a network analyses

Korsakoff syndrome (KS) is a neuropsychiatric disorder characterized by cognitive impairments such as episodic memory loss, executive dysfunctioning and confabulations. Problem behavior such as agitation, restlessness and apathy are also highly prevalent in patients with KS. The presence of cognitive impairments and problem behavior often constitute a reason for institutionalization in long-term care facilities (LTCF). Recently, it was demonstrated that altered awareness, an overestimation of one’s own capabilities, was also highly common in KS patients living in Dutch LTCFs (Gerridzen et al. 2019). We believe that altered awareness might be associated with problem behavior and reduced functioning and in turn poses challenges for good care provision. Therefore, we assessed how altered awareness relates to cognitive, neuropsychiatric, social and physical functioning by applying a network analyses. We used an existing dataset from a retrospective, cross-sectional study of KS patients (N=210) living in Dutch nursing homes (Gerridzen et al. 2019). Our results demonstrate that altered awareness was a central node in the network. Altered awareness was directly associated with impaired cognition and reduced social participation yet also with increased quality of life. Only apathy was directly related to altered awareness, the other neuropsychiatric symptoms were only indirectly related. Apathy was also a central node and higher apathy scores related directly to impaired cognition, reduced social participation and to more physical dependence. This study sheds new light on the central role that altered awareness plays in the functioning and behavior of patients with KS living in LTCFs

Reversed takotsubo cardiomyopathy in a patient with new-onset multiple sclerosis: Cause, link, or just coincidence?

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Don't judge the myocardium by its cover : The incremental value of cardiac magnetic resonance imaging in left ventricular hypertrophy

Contains fulltext : 190547.pdf (publisher's version ) (Open Access

Cardiovascular magnetic resonance techniques for tissue characterization after acute myocardial injury

Contains fulltext : 209405.pdf (publisher's version ) (Closed access)The annual incidence of hospital admission for acute myocardial infarction lies between 90 and 312 per 100 000 inhabitants in Europe. Despite advances in patient care 1 year mortality after ST-segment elevation myocardial infarction (STEMI) remains around 10%. Cardiovascular magnetic resonance imaging (CMR) has emerged as a robust imaging modality for assessing patients after acute myocardial injury. In addition to accurate assessment of left ventricular ejection fraction and volumes, CMR offers the unique ability of visualization of myocardial injury through a variety of imaging techniques such as late gadolinium enhancement and T2-weighted imaging. Furthermore, new parametric mapping techniques allow accurate quantification of myocardial injury and are currently being exploited in large trials aiming to augment risk management and treatment of STEMI patients. Of interest, CMR enables the detection of microvascular injury (MVI) which occurs in approximately 40% of STEMI patients and is a major independent predictor of mortality and heart failure. In this article, we review traditional and novel CMR techniques used for myocardial tissue characterization after acute myocardial injury, including the detection and quantification of MVI. Moreover, we discuss clinical scenarios of acute myocardial injury in which the tissue characterization techniques can be applied and we provide proposed imaging protocols tailored to each scenario