PET imaging of hypoxia using [F-18]HX4: a phase I trial

 Download the images using these instructions and this DOI : 10.1007/s00259-010-1437-x Background and purposeNon-invasive PET imaging of tumour hypoxia could help in the selection of those patients who could benefit from chemotherapy or radiation with specific antihypoxic treatments such as bioreductive drugs or hypoxic radiosensitizers. In this phase I trial, we aimed to determine the toxicity of [18F]HX4, a member of the 2-nitroimidazole family, at different dose levels. The secondary aim was to analyse image quality related to the HX4 dose and the timing of imaging.MethodsPatients with a..

Bemerkungen zu Papyri XXXII: 886–949

<Korr. Tyche> 886–94

Buchbesprechungen

Thomas Backhuys, Kölner Papyri (P. Köln) Band 16 (Pap.Colon. VII/16), Paderborn 2018  Nathan Badoud, Inscriptions et timbres céramiques de Rhodes. Documents recueillis par le médecin et explorateur suédois Johan Hedenborg (1786–1865) (Acta Instituti Atheniensis Regni Sueciae, Series in 4°, 57), Stockholm 2017 T. Berg, L’Hadrianus de Montserrat (P.Monts.Roca III, inv. 162→ – 165↓). Édition, traduction et analyse contextuelle d’un récit latin conservé sur papyrus (Papyrologica Leodiensia 8), Liège 2018  Henning Börm, Nino Luraghi (eds.), The Polis in the Helle­nistic World, Stuttgart 2018  Katharina Bolle, Carlos Machado, Christian Witschel (eds.), The Epigraphic Cultures of Late Antiquity (Heidelberger Alt­historische Beiträge und Epigraphische Studien 60), Stuttgart 2017  Anne Daguet-Gagey, Splendor aedilitatum. L’édilité à Rome (Ier s. avant J.-C. – IIIe s. après J.-C.) (Collection de l’école française de Rome 498), Rome 2015  Julien Fournier, Marie-Gabrielle G. Parissaki (eds.), Les communautés du Nord Égéen au temps de l’hégémonie romaine. Entre ruptures et continuités (Μελετήματα 77), Athen 2018  Katharina Knäpper, Hieros kai asylos. Territoriale Asylie im Hellenismus in ihrem historischen Kontext (Historia Einzelschriften 250), Stuttgart 201

Bemerkungen zu Papyri XXXI: 855–885

<Korr. Tyche> 855–885<Korr. Tyche> 855–88

The Dynamic Relationship between Invasive Microvascular Function and Microvascular Injury Indicators, and Their Association with Left Ventricular Function and Infarct Size at 1-Month after Reperfused ST-Segment-Elevation Myocardial Infarction

Background: The invasive microvascular function indices, coronary flow reserve (CFR) and the index of microcirculatory resistance (IMR), exhibit a dynamic pattern after ST-segment-elevation myocardial infarction. The effects of microvascular injury on the evolution of the microvascular function and the prognostic significance of the evolution of microvascular function are unknown. We investigated the relationship between the temporal changes of CFR and IMR, and cardiovascular magnetic resonance-derived microvascular injury characteristics in reperfused ST-segment-elevation myocardial infarction patients, and their association with 1-month left ventricular ejection fraction and infarct size (IS). Methods: In 109 ST-segment-elevation myocardial infarction patients who underwent angiography for primary percutaneous coronary intervention (PPCI) and at 1-month follow-up, invasive assessment of CFR and IMR were performed in the culprit artery during both procedures. Cardiovascular magnetic resonance was performed 2 to 7 days after PPCI and at 1 month and provided assessment of left ventricular ejection fraction, IS, microvascular obstruction, and intramyocardial hemorrhage. Results: CFR and IMR significantly changed over 1 month (both, P50% and extensive IS (the highest quartile). Conclusions: In reperfused ST-segment-elevation myocardial infarction patients, CFR and IMR significantly improved 1 month after PPCI; the temporal change in IMR is closely related to the presence/absence of microvascular damage and IS. ΔIMR exhibits a stronger association for 1-month functional outcome than post-PPCI CFR, IMR, or ΔCFR

Collaboration around rare bone diseases leads to the unique organizational incentive of the Amsterdam Bone Center

In the field of rare bone diseases in particular, a broad care team of specialists embedded in multidisciplinary clinical and research environment is essential to generate new therapeutic solutions and approaches to care. Collaboration among clinical and research departments within a University Medical Center is often difficult to establish, and may be hindered by competition and non-equivalent cooperation inherent in a hierarchical structure. Here we describe the “collaborative organizational model” of the Amsterdam Bone Center (ABC), which emerged from and benefited the rare bone disease team. This team is often confronted with pathologically complex and under-investigated diseases. We describe the benefits of this model that still guarantees the autonomy of each team member, but combines and focuses our collective expertise on a clear shared goal, enabling us to capture synergistic and innovative opportunities for the patient, while avoiding self-interest and possible harmful competition

Collaboration Around Rare Bone Diseases Leads to the Unique Organizational Incentive of the Amsterdam Bone Center

In the field of rare bone diseases in particular, a broad care team of specialists embedded in multidisciplinary clinical and research environment is essential to generate new therapeutic solutions and approaches to care. Collaboration among clinical and research departments within a University Medical Center is often difficult to establish, and may be hindered by competition and non-equivalent cooperation inherent in a hierarchical structure. Here we describe the “collaborative organizational model” of the Amsterdam Bone Center (ABC), which emerged from and benefited the rare bone disease team. This team is often confronted with pathologically complex and under-investigated diseases. We describe the benefits of this model that still guarantees the autonomy of each team member, but combines and focuses our collective expertise on a clear shared goal, enabling us to capture synergistic and innovative opportunities for the patient, while avoiding self-interest and possible harmful competition