Massive Liver Cell Necrosis Induced in the Pig with Carbon Tetrachloride

An attempt was made to induce massive liver necrosis in the pig by the injection of varying doses of carbon tetrachloride into the afferent vessels of the liver. The optimal route and dose of injection were assessed as well as the effect of prior phenobarbitone administration. Survival, and biochemical and histological changes were noted. A preliminary trial of exchange transfusion showed that the model could be used, but a number of variables complicates evaluation in this biological system. A large number of animals would be needed under strictly paired conditions in order to draw significant conclusions.S. Afr. Med. J., 48, 1201 (1974)