16 research outputs found
Low Arginine Plasma Levels do not Aggravate Renal Blood Flow after Experimental Renal Ischaemia/reperfusion
AbstractBackground: ischaemic renal dysfunction is present in many clinical settings, including cardiovascular surgery. Renal hypoperfusion seems to be the most important pathophysiologic mechanism. Arginine plasma levels are rate limiting for NO synthesis, and low arginine plasma levels are seen after major vascular surgery. Objective: to establish the effects of low arginine plasma levels on renal blood flow after renal ischaemia/reperfusion. Design: Wistar rats were used in this unilateral renal ischaemia/reperfusion model. After 70 min of ischaemia, the kidney was reperfused for 150 min. Arginase infusion was used to lower arginine plasma levels. Blood flow measurement was performed at the end of the experiment using radiolabelled microspheres. Additional experiments were performed for histopathology. Results: arginase efficiently decreased arginine plasma levels to about 50% of normal. There was a lower blood flow in the ischaemic kidney than the contralateral (non-ischaemic) kidney. Lowering arginine plasma levels did not reduce renal blood flow in the ischaemic kidney. Renal histopathology was not influenced by lowered arginine plasma levels. Conclusions: lowering arginine plasma levels did not affect blood flow or histology following renal ischaemia and reperfusion
The role of inducible nitric oxide synthase in lipopolysaccharide-mediated hyporeactivity to vasoconstrictors differs among isolated rat arteries
Arginine deficiency in bile duct ligated rats after surgery: the role of plasma arginase and gut endotoxin restriction
Muscle Microvascular Reactivity in 6-weeks Diabetic Rats with Comparatively Moderate Hyperglycemia.International Journal of Microcirculation Clinical and Experimental
The liver is an important organ in the metabolism of asymmetrical dimethylarginine (ADMA).
Vascular Reactivity in Differently Sized Arterioles of Spinotrapezius Muscle in Diabetic Rats
Increasing Nitric Oxide Dependency of Microvascular Reactivity in Rats during 6-weeks of Hyperglycemia. International Journal of Microcirculation Clinical and Experimental
The effect of mild endotoxemia during low arginine plasma levels on organ blood flow in rats.
Heterogeneity of local metabolism and perfusion - Measuring local myocardial O-2 consumption in situ using frozen samples
An Agent Model for Analysis of Human Performance Quality
A human's performance in a complex task is highly dependent on the demands of the task, in the sense that highly demanding situations will often cause a degradation of performance. To maintain performance quality usually extra effort has to be contributed. However, the resources for such extra effort available to the human are limited. In this paper an agent model is proposed in which different types of relations between effort, task demands and performance quality can be used to analyse the human's performance quality. It is illustrated how a support agent incorporating this model can support a human based on different performance criteria. The agent model thus allows to build agent applications that provide optimal support depending on a specific situation and goal of the task. © 2010 IEEE