Exploring the self in adolescent depression: neural mechanisms underlying social evaluations and self-views from a parent-adolescent perspective

This dissertation focuses on identifying neural mechanisms underlying social evaluations and self-views from a parent-adolescent perspective among adolescents with and without depression, and their parents. As part of RE-PAIR, affective and neural responses to praise and criticism about the adolescent child, and neural responses to reliving positive autobiographical memories were assessed, using ecologically valid fMRI-tasks. Particularly criticism seems to be highly salient to parents and adolescents, activating the salience network and decreasing mood. Both praise and reliving positive autobiographical memories activate areas important for self-referential processing in adolescents, which might reflect the ‘positive self’. Aberrant self-related processing when reliving autobiographical memories and increased sensitivity to parental criticism might be key underlying neural mechanisms in adolescent depression. By feeling more negatively, having more negative self-views, interpreting the environment as more negatively, memorizing past experiences in a more negative way, and focusing on negative events more often, adolescents with depression seem to have multiple negativity biases. These negativity biases are likely to negatively impact social relationships, potentially further reinforcing negative feelings and a negative self. Interventions exploring and strengthening the positive self, in particular the positive self aligning with the current self, might be useful for treating, or even preventing adolescent depression.All research described in this dissertation was supported by the Netherlands Organisation for Scientific Research (NWO) through a VICI Grant 453-15-006 awarded to prof.dr. Bernet M. Elzinga. Lisanne A.E.M. van Houtum was additionally funded by the Ter Meulen Grant of the Royal Netherlands Academy of Arts and Sciences (KNAW).Stress and Psychopatholog

Perceptions of parenting in daily life: adolescent-parent differences and associations with adolescent affect

Adolescents can perceive parenting quite differently than parents themselves and these discrepancies may relate to adolescent well-being. The current study aimed to explore how adolescents and parents perceive daily parental warmth and criticism and whether these perceptions and discrepancies relate to adolescents' daily positive and negative affect. The sample consisted of 80 adolescents (M-age = 15.9; 63.8% girls) and 151 parents (M-age = 49.4; 52.3% women) who completed four ecological momentary assessments per day for 14 consecutive days. In addition to adolescents' perception, not parents' perception by itself, but the extent to which this perception differed or overlapped with adolescents' perception was related to adolescent affect. These findings highlight the importance of including combined adolescents' and parents' perspectives when studying dynamic parenting processes.Stress and Psychopatholog

Vicarious praise and pain: parental neural responses to social feedback about their adolescent child

FSW - Self-regulation models for health behavior and psychopathology - ou

Neural and affective responses to prolonged eye contact with one's own adolescent child and unfamiliar others

Stress and Psychopatholog

Adolescents’ affective and neural responses to parental praise and criticism

Social feedback from parents has a profound impact on the development of a child's self-concept. Yet, little is known about adolescents’ affective and neural responses to parental social feedback, such as criticism or praise. Adolescents (n = 63) received standardized social feedback supposedly provided by their mother or father in the form of appraisals about their personality (e.g., ‘respectful’, ‘lazy’) during fMRI scanning. After each feedback word, adolescents reported their mood. Additionally, adolescents had rated whether feedback words matched their self-views on an earlier occasion. In line with preregistered hypotheses, negative parental feedback worsened adolescents’ mood, which was exacerbated when feedback did not match adolescents’ self-views. Negative feedback was associated with increased activity in the neural ‘saliency network’, including anterior insula, anterior cingulate cortex and dorsomedial prefrontal cortex. Positive feedback improved mood and increased activity in brain regions supporting social cognition, including temporoparietal junction, posterior superior temporal sulcus, and precuneus. A more positive general self-view and perceived parental warmth were associated with elevated mood, independent of feedback valence, but did not impact neural responses. Taken together, these results enhance our understanding of adolescents’ neural circuitry involved in the processing of parental praise and criticism, and the impact of parental feedback on well-being

A qualitative, multi-perspective study on causal beliefs about adolescent depression

Health and Well-bein

Eyes on you: ensuring empathic accuracy or signalling empathy?

Stress and Psychopatholog

Looking into troubled waters: Childhood emotional maltreatment modulates neural responses to prolonged gazing into one’s own, but not others’ eyes

Stress and Psychopatholog

Neural and Affective Responses to Prolonged Eye Contact with One's Own Adolescent Child and Unfamiliar Others

Eye contact is crucial for the formation and maintenance of social relationships, and plays a key role in facilitating a strong parent-child bond. However, the precise neural and affective mechanisms through which eye contact impacts on parent-child relationships remain elusive. We introduce a task to assess parents’ neural and affective responses to prolonged direct and averted gaze coming from their own child, and an unfamiliar child and adult. While in the scanner, 79 parents (n = 44 mothers and n = 35 fathers) were presented with prolonged (16-38 s) videos of their own child, an unfamiliar child, an unfamiliar adult, and themselves (i.e., targets), facing the camera with a direct or an averted gaze. We measured BOLD-responses, tracked parents’ eye movements during the videos, and asked them to report on their mood and feelings of connectedness with the targets after each video. Parents reported improved mood and increased feelings of connectedness after prolonged exposure to direct versus averted gaze and these effects were amplified for unfamiliar targets compared to their own child, due to high affect and connectedness ratings after videos of their own child. Neuroimaging results showed that the sight of one's own child was associated with increased activity in middle occipital gyrus, fusiform gyrus and inferior frontal gyrus relative to seeing an unfamiliar child or adult. While we found no robust evidence of specific neural correlates of eye contact (i.e., contrast direct > averted gaze), an exploratory parametric analysis showed that dorsomedial prefrontal cortex (dmPFC) activity increased linearly with duration of eye contact (collapsed across all “other” targets). Eye contact-related dmPFC activity correlated positively with increases in feelings of connectedness, suggesting that this region may drive feelings of connectedness during prolonged eye contact with others. These results underline the importance of prolonged eye contact for affiliative processes and provide first insights into its neural correlates. This may pave the way for new research in individuals or pairs in whom affiliative processes are disrupted