Low-dimensional hybrid perovskites containing an organic cation with an extended conjugated system : tuning the excitonic absorption features

Low-dimensional hybrid perovskites are receiving increased attention. One of the advantages of the low-dimensional hybrids over their 3D counterparts is their greater structural flexibility towards the incorporation of bigger, more complex, organic cations. In this communication, we introduce a pyrene derivative as an organic cation containing an extended pi-system for use in a variety of low-dimensional hybrids. We show that materials with different excitonic absorption features can be obtained by tuning the iodide/lead ratio in the precursor solutions, using the same pyrene cation. In this way, hybrids with optical characteristics corresponding to 2D, 1D and 0D hybrid perovskites are obtained. The formation and thermal stability of the different hybrids is analysed and compared

Clinical decision rules and measuring renal function in community pharmacy: what do we get out of it?

OBJECTIVE To investigate the frequency and management of drug therapy alerts about drug use in patients with (potential) renal impairment, to investigate the contribution of point-of-care testing (PoCT) of renal function in community pharmacy to the availability of information on renal function, and to investigate pharmacists’ experiences with drug therapy alerts and PoCT. DESIGN AND METHODS A clinical decision support system with clinical decision rules for eleven drugs (seven antibiotics, sotalol, digoxin, allopurinol and spironolactone) and PoCT of renal function were implemented in community pharmacies. The clinical decision rules generated an alert when dose adjustment was advised based on a registered impaired renal function, and when information on the renal function was lacking for patients over 70 years of age with a prescription for one of the selected drugs. Data registered in the clinical decision support system regarding generated alerts, renal functions and alert management were analysed retrospectively. In addition, the participating pharmacists filled out a questionnaire about their experiences. RESULTS 336 pharmacists managed 27.307 alerts for 21.494 patients, leading to 362 dose adjustments and 65 drug replacements. For 16.208 of these patients, renal function has been registered in the clinical decision support system, including over 400 PoCT measurements. Based on PoCT, 25 cases of impaired renal function have been registered, leading to two therapy adjustments. The participating pharmacists were positive about the project. CONCLUSION Advanced clinical decision rules on renal function led to over 400 therapy adjustments. PoCT is a potentially useful source of information on renal function in a limited number of cases, when this information is urgently needed and not available from other sources