CroMe interview with Slavko Komar

Slavko Komar was born in Gospić, Croatia in 1918. He went to school in Zagreb, where he got a law degree. In 1937 he became a member of Young Communist League of Yugoslavia. He participated in many political actions during World War II. Because of his activities he was forced to go underground. On august 4th 1941 he led one of the biggest actions against the Ustashe regime in Zagreb, known as ""Botanical Garden"". He and his group attacked an Ustashe patrol in Runjanin Street. Because of constant surveillance he left Zagreb and joined the National Liberation Army. In 1944 he was elected as one of the members of National Anti-Fascist Council of the People's Liberation of Croatia (ZAVNOH). During and after the war he held a number of high positions. He was in charge of leading the agrarian reform in the aftermath of World War II. This part of his activities he considers to be his biggest achievement in building socialism. He was decorated with the Order of the People's Hero of Yugoslavia in 1952. He died in Zagreb in 2012

Homologous Recombination Deficiency and Cyclin E1 Amplification Are Correlated with Immune Cell Infiltration and Survival in High-Grade Serous Ovarian Cancer

Background: How molecular profiles are associated with tumor microenvironment (TME) in high-grade serous ovarian cancer (HGSOC) is incompletely understood. Therefore, we analyzed the TME and molecular profiles of HGSOC and assessed their associations with overall survival (OS). Methods: Patients with advanced-stage HGSOC treated in three Dutch hospitals between 2008–2015 were included. Patient data were collected from medical records. BRCA1/2 mutation, BRCA1 promotor methylation analyses, and copy number variations were used to define molecular profiles. Immune cells were assessed with immunohistochemical staining. Results: 348 patients were categorized as BRCA mutation (BRCAm) (BRCAm or promotor methylation) (30%), non-BRCA mutated HRD (19%), Cyclin E1 (CCNE1)-amplification (13%), non-BRCAmut HRD and CCNE1-amplification (double classifier) (20%), and no specific molecular profile (NSMP) (18%). BRCAm showed highest immune cell densities and CCNE1-amplification lowest. BRCAm showed the most favorable OS (52.5 months), compared to non-BRCAmut HRD (41.0 months), CCNE1-amplification (28.0 months), double classifier (27.8 months), and NSMP (35.4 months). Higher immune cell densities showed a favorable OS compared to lower, also within the profiles. CD8+, CD20+, and CD103+ cells remained associated with OS in multivariable analysis. Conclusions: Molecular profiles and TME are associated with OS. TME differs per profile, with higher immune cell densities showing a favorable OS, even within the profiles. HGSOC does not reflect one entity but comprises different entities based on molecular profiles and TME