Error and post-error processing in children with attention-deficit/hyperactivity disorder:An electrical neuroimaging study

Objective: Inaccurate and inconsistent response styles in attention-deficit/hyperactivity disorder (ADHD) have been observed in a wide variety of cognitive tasks, in line with regulatory deficit models of ADHD. Event-related potential (ERP) studies of error processing have provided evidence for these models, but are limited in specificity. We aimed to improve the isolation, localization and identification of error (self-monitoring and adaptive control) and post-error (implementation of cognitive control) processing in ADHD. Methods: ERPs were obtained for 46 ADHD and 51 typically developing (TD) children using the stop-signal task. Response-locked error (Ne and Pe) and stimulus-locked post-error (N2) components were compared between groups. Ne/Pe were corrected for preceding stimulus overlap and group differences were localized. Results: Ne was intact, while Pe amplitude was markedly reduced in children with ADHD (ηp2 = 0.14). Pe differences were localized in the dorsal posterior/midcingulate (BA31/24) cortex. While the TD group showed increased N2 amplitude in post-error trials (ηp2 = 0.24), localized in the left ventrolateral prefrontal cortex (VLPFC) and angular gyrus, the ADHD group did not. Conclusions: Self-regulation deficits in ADHD are associated with later stages of error processing and subsequent implementation of cognitive control. Significance: We contribute to the literature by further specifying error processing deficits in ADHD

fMR-adaptation indicates selectivity to audiovisual content congruency in distributed clusters in human superior temporal cortex

<p>Abstract</p> <p>Background</p> <p>Efficient multisensory integration is of vital importance for adequate interaction with the environment. In addition to basic binding cues like temporal and spatial coherence, meaningful multisensory information is also bound together by content-based associations. Many functional Magnetic Resonance Imaging (fMRI) studies propose the (posterior) superior temporal cortex (STC) as the key structure for integrating meaningful multisensory information. However, a still unanswered question is how superior temporal cortex encodes content-based associations, especially in light of inconsistent results from studies comparing brain activation to semantically matching (congruent) versus nonmatching (incongruent) multisensory inputs. Here, we used fMR-adaptation (fMR-A) in order to circumvent potential problems with standard fMRI approaches, including spatial averaging and amplitude saturation confounds. We presented repetitions of audiovisual stimuli (letter-speech sound pairs) and manipulated the associative relation between the auditory and visual inputs (congruent/incongruent pairs). We predicted that if multisensory neuronal populations exist in STC and encode audiovisual content relatedness, adaptation should be affected by the manipulated audiovisual relation.</p> <p>Results</p> <p>The results revealed an occipital-temporal network that adapted independently of the audiovisual relation. Interestingly, several smaller clusters distributed over superior temporal cortex within that network, adapted stronger to congruent than to incongruent audiovisual repetitions, indicating sensitivity to content congruency.</p> <p>Conclusions</p> <p>These results suggest that the revealed clusters contain multisensory neuronal populations that encode content relatedness by selectively responding to congruent audiovisual inputs, since unisensory neuronal populations are assumed to be insensitive to the audiovisual relation. These findings extend our previously revealed mechanism for the integration of letters and speech sounds and demonstrate that fMR-A is sensitive to multisensory congruency effects that may not be revealed in BOLD amplitude per se.</p

The reported effects of neuroscience literacy and belief in neuromyths among parents of adolescents

Neuroscience research has increased our understanding of brain development, but little is known about how parents of adolescents engage with this neuroscientific information. Dutch parents completed a digital survey on neuromyths, neuroscience literacy and views of the adolescent brain and behaviour. These parents believed 44.7% of neuromyths and showed reasonable neuroscience literacy (79.8%). Stronger neuromyth belief predicted a more negative view on adolescent brain development. About 68% of the parents reported that they had changed their parenting behaviour based on their understanding of neuroscientific findings. These self-reported changes most often reflected changes to parents’ own behaviour. The results of this study underline the importance for scientists and parents to engage in scientific activities to promote respectful and trusting relationships between them. These relationships have the potential to make communication about adolescent brain development between scientists and parents more effective and will empower parents to use correct information as a basis for their decisions around raising their adolescents

Neural, behavioural and real-life correlates of social context sensitivity and social reward learning during interpersonal interactions in the schizophrenia spectrum

Objective Recent findings suggest that diminished processing of positive contextual information about others during interactions may contribute to social impairment in the schizophrenia spectrum (SZ). This could be due to general social context processing deficits or specific biases against positive information. We studied the impact of positive and negative social contextual information during social interactions using functional neuroimaging and probed whether these neural mechanisms were associated with reallife social functioning in SZ. Methods Patients with SZ (N=23) and controls (N=25) played three multi-round trust games during fMRI scanning, with no, positive and negative information about the counterpart’s trustworthiness, while all counterparts were programmed to behave trustworthy. The main outcome variable was the height of the shared amount in the trust game, i.e. investment, representing an indication of trust. The first investment in the game was considered to be basic trust, since no behavioural feedback was given yet. We performed region-of-interest analyses and examined the association with real-life social functioning using the Experience Sampling Method. Results Social contextual information had no effect on patients’ first investments, whereas controls made the lowest investment after negative and the highest investments after positive contextual information was provided. Over trials, patients decreased investments, suggesting reduced social reward learning, whereas controls increased investments in response to behavioural feedback in the negative context. Patients engaged the dorsolateral prefrontal cortex (dlPFC) less than controls during context presentation and showed reduced activity within the caudate during repayments. In patients, lower investments were associated with more time spent alone and social exclusion and lower caudate activation was marginally significantly associated with higher perceived social exclusion. Conclusion The failure to adapt trust to positive and negative social contexts suggests that patients have a general insensitivity to prior social information, indicating top-down processing impairments. In addition, patients show reduced sensitivity to social reward, i.e. bottom-up processing deficits. Moreover, lower trust and lower neural activation were related to lower real-life social functioning. Together, these findings indicate that improving trust and social interactions in SZ needs a multi-faceted approach that targets both mechanisms

The effect of incorrect prior information on trust behavior in adolescents

During adolescence, social cognition and the brain undergo major developments. Social interactions become more important, and adolescents must learn that not everyone can be trusted equally. Prior knowledge about the trustworthiness of an interaction partner may affect adolescents' expectations about the partner. However, the expectations based on prior knowledge can turn out to be incorrect, causing the need to respond adaptively during the interaction. In the current fMRI study, we investigated the effect of incorrect prior knowledge on adolescent trust behavior and on the neural processes of trust. Thirty-three adolescents (Mage = 17.2 years, SDage = 0.5 years) played two trust games with partners whose behavior was preprogrammed using an algorithm that modeled trustworthy behavior. Prior to the start of both games, participants received information suggesting that the partner in one game was untrustworthy (raising incorrect expectations) and the partner in the other game trustworthy (raising correct expectations). Results indicated that participants adapted their trust behavior following incorrect prior expectations. No evidence for a change in trust behavior was shown when prior expectations were correct. fMRI analyses revealed that when receiving the partner's response, activity in the dorsolateral prefrontal cortex and in the superior parietal gyrus were increased when participants had incorrect expectations about the partner compared to when participants had correct expectations. When making trust decisions, no significant differences in neural activity were found when comparing the two games. This study provides insight into how adolescent trust behavior and neural mechanisms are affected by expectations and provides an increased understanding of the factors that influence adolescent social interaction

When a photograph can be heard: Vision activates the auditory cortex within 110 ms

As the makers of silent movies knew well, it is not necessary to provide an actual auditory stimulus to activate the sensation of sounds typically associated with what we are viewing. Thus, you could almost hear the neigh of Rodolfo Valentino's horse, even though the film was mute. Evidence is provided that the mere sight of a photograph associated with a sound can activate the associative auditory cortex. High-density ERPs were recorded in 15 participants while they viewed hundreds of perceptually matched images that were associated (or not) with a given sound. Sound stimuli were discriminated from non-sound stimuli as early as 110 ms. SwLORETA reconstructions showed common activation of ventral stream areas for both types of stimuli and of the associative temporal cortex, at the earliest stage, only for sound stimuli. The primary auditory cortex (BA41) was also activated by sound images after ∼ 200 ms