Export Orientation among New Ventures and Economic Growth

While it is generally acknowledged that entrepreneurship as well as export activity may both be important strategies for achieving national economic growth, it has remained unclear how export activity among new ventures is related to economic growth. This paper investigates whether the presence of export-oriented entrepreneurs is a more important determinant of economic growth than entrepreneurial activity in general. We focus on the national or macro-level and use data from the Global Entrepreneurship Monitor for a sample of 36 countries. An important advantage of using the macrolevel is that indirect effects of exporting entrepreneurs that reach further than the performance of these firms themselves (e.g. spillovers) are captured in the analysis. To our knowledge, no attempt has been made thus far to link international activity of early-stage ventures to macro-economic outcomes. Our results suggest that export-oriented entrepreneurship is indeed more important for achieving high economic growth rates than entrepreneurial activity in general. This suggests that international activity by small and new firms strongly contributes to higher levels of competition and, consequently, to the emergence of highly dynamic economies and higher levels of economic growth.

The Role of Export-Driven New Ventures in Economic Growth: A Cross-Country Analysis

We investigate the relationship between a country’s prevalence of new ventures and its rate of economic growth, while distinguishing between export-oriented new ventures and domestic new ventures. It is generally acknowledged that new venture creation as well as export activity may both be important strategies for achieving national economic growth. However, to our knowledge no attempt has been made to empirically investigate the role of export-driven new ventures in economic growth. We focus on the national level and use data from the Global Entrepreneurship Monitor for a sample of 36 countries. Our results suggest that a country’s prevalence of export-driven new ventures is significantly positively related to economic growth, whereas the prevalence of new ventures that focus exclusively on domestic market sales shows no significant relation to national growth.

Functions of p120ctn in development and disease

p120 catenin (p120ctn), a component of the cadherin-catenin complex, was the first member to be identified in a most interesting subfamily of the Armadillo family. Several p120ctn isoforms are generated by alternative splicing. These isoforms fulfill pleiotropic functions according to their subcellular localization: modulating the turnover rate of membrane-bound cadherins, regulating the activation of small Rho GTPases in the cytoplasm, and modulating nuclear transcription. Over the last two decades, knowledge of p120ctn has grown remarkably, and this has been achieved in part by using different animal models. At least in frog and mammals, p120ctn is essential for normal development and homeostasis. Here we will discuss the effects of different p120ctn isoforms on cadherin turnover and on signaling in the cytoplasm and the nucleus. We will also elaborate on the structure and function of other members of the p120ctn subfamily: ARVCF, p0071 and delta-catenin. Finally, we will overview the respective roles of p120ctn family members in pathological processes, and particularly in cancer as p120ctn is frequently downregulated or mislocalized in various human tumors

Functions of p120ctn isoforms in cell-cell adhesion and intracellular signaling

The functions of many organs depend on the generation of an epithelium. The transition from a set of loosely connected nonpolarized cells to organized sheets of closely associated polarized epithelial cells requires the assembly of specialized cell junctions. In vertebrates, three major types of junctions are responsible for epithelial integrity: adherens junctions, tight junctions, and desmosomes. p120 catenin (p120ctn) is an Armadillo family member and a component of the cadherin-catenin complex in the adherens junction. It fulfils pleiotropic functions according to its subcellular localization: modulating the turnover rate of membrane-bound cadherins, regulating the activation of small RhoGTPases in the cytoplasm, and modulating nuclear transcription. Over the last two decades, knowledge of p120ctn obtained from in vitro experiments has been confirmed and extended by using different animal models. It has become clear that p120ctn is essential for normal development and homeostasis, at least in frog and mammals. p120ctn is a Src substrate that can be phosphorylated at different tyrosine, serine and threonine residues and can dock various kinases and phosphatases. Thereby, p120ctn regulates the phosphorylation status and the junctional stability of the cadherin-catenin complex. Multiple p120ctn isoforms are generated by alternative splicing, which allows the translation to be initiated from four start codons and enables the inclusion of four alternatively used exons. We will discuss the effects of different p120ctn isoforms on cadherin turnover and intracellular signaling, in particular RhoGTPase activity and phosphorylation events

Entrepreneurial exit, ability and engagement across countries in different stages of development

Entrepreneurial ability has been suggested to be an important predictor of entrepreneurial engagement. In this paper we investigate the extent to which different types of recent entrepreneurial exit experiences foster entrepreneurial ability and subsequent entrepreneurial engagement. We discriminate between several exit modes and distinguish the following engagement levels: potential, intentional, nascent, young and established entrepreneurship. We use individual-level data for 67 countries that participated in the Global Entrepreneurship Monitor during 2007, 2008 and 2009. Our findings indeed show that entrepreneurial exit directly fosters entrepreneurial engagement as well as indirectly through enhanced entrepreneurial ability. We also find dat positive as well as negative exit experiences foster subsequent entrepreneurial engagement. In addition, the impacts of exit on ability and exit on engagement increase with the stage of development of a country.

Motivation based policies for an entrepreneurial EU economy

This paper investigates the impact of various entrepreneurial motives and institutional conditions on entrepreneurial aspirations in terms of innovativeness, job growth expectations and export orientation. We estimate a two-equation model explaining entrepreneurial motivations and entrepreneurial aspirations, while taking into account the interrelationship between both groups of variables. We use data from the Global Entrepreneurship Monitor (GEM) and find that entrepreneurial aspirations are different for various types of entrepreneurial motives. For example, we find that the increase wealth motive as a prime driver for becoming selfemployed is positively related to innovation and growth ambitions, whereas we find no evidence of a relation between the independence motive and entrepreneurial aspirations. On the basis of our findings policy directions are presented for an entrepreneurial EU economy. An updated version of this paper is numbered H200710.

Zebrafish teeth as a model for repetitive epithelial morphogenesis: dynamics of E-cadherin expression

Background: The development of teeth is the result of interactions between competent mesenchyme and epithelium, both of which undergo extensive morphogenesis. The importance of cell adhesion molecules in morphogenesis has long been acknowledged but remarkably few studies have focused on the distribution and function of these molecules in tooth development. Results: We analyzed the expression pattern of an important epithelial cadherin, E-cadherin, during the formation of first-generation teeth as well as replacement teeth in the zebrafish, using in situ hybridization and whole mount immunostaining to reveal mRNA expression and protein distribution. E-cadherin was detected in every layer of the enamel organ during the different stages of tooth development, but there were slight differences between first-generation and replacement teeth in the strength and distribution of the signal. The dental papilla, which is derived from the mesenchyme, did not show any expression. Remarkably, the crypts surrounding the functional teeth showed an uneven distribution of E-cadherin throughout the pharyngeal region. Conclusions: The slight differences between E-cadherin expression in zebrafish teeth and developing mouse and human teeth are discussed in the light of fundamental differences in structural and developmental features of the dentition between zebrafish and mammals. Importantly, the uninterrupted expression of E-cadherin indicates that down-regulation of E-cadherin is not required for formation of an epithelial tooth bud. Further research is needed to understand the role of other cell adhesion systems during the development of teeth and the formation of replacement teeth

Drivers of entrepreneurial aspirations at the country lever: the role of start-up motivations and social security

This paper investigates whether start-up motivations and the level of social security can explain entrepreneurial aspirations. We use country-level data from the Global Entrepreneurship Monitor (GEM) for the year 2005. We distinguish between the necessity motive, independence motive and increase wealth motive and look at entrepreneurial aspirations in terms of innovativeness, job growth expectations and export orientation. As an indicator of a country?s level of social security we take the social security contribution rate (for employer?s and employees) from the World Competitiveness Yearbook. Previous research has found a negative relationship between the level of entrepreneurial activity and social security contributions, suggesting that social security increases the opportunity costs for entrepreneurship. The results of this study complement these previous findings by indicating that social security contributions have a negative influence on the supply of ambitious entrepreneurship in terms of new product or service introductions, job growth and export orientation. Furthermore, our findings indicate that entrepreneurial aspirations in terms of job growth and export relate positively to the increase wealth motive, whereas no significant relationship is found between our aspiration variables and the independence and necessity motives. On the basis of our findings policy directions are presented for an entrepreneurial economy. This is an update of paper H200627.

New Ventures' Export Orientation: Outcome and Source of Knowledge Spillovers

In this paper we draw on knowledge spillover literature to suggest that a country’s proportion of exportoriented new ventures, compared to its total number of new ventures, represents an outcome of knowledge spillovers (export spillovers) that stem from foreign direct investment (FDI) and international trade, as well as a source of knowledge spillovers (entrepreneurship spillovers) that positively influence the country’s total level of entrepreneurial activity. We distinguish between higher-income and lower-income countries, because the latter are less integrated into the world economy. To test the hypotheses, we use macro-level data from 34 countries during the period 2002–2005. After controlling for relevant factors such as size of the domestic market and industry structure, we find that the relationship between FDI and international trade on the one hand and a country’s proportion of export-oriented new ventures on the other differs for higherand lower-income countries. In addition, a country’s proportion of export-oriented new ventures affects the subsequent emergence of new businesses. These findings have important implications for research and practice. This is an update of paper H200619.

Knowledge spillovers and entrepreneurs' export orientation

In this paper we draw upon the economics literature, and the literature on knowledge spillovers in particular, to examine to what extent a country's level of foreign direct investment (both inward and outward) and international trade (export and import) influence the export orientation of its entrepreneurs. We also examine the relationship between entrepreneurs export orientation and a country's overall level of entrepreneurial activity. We test our hypotheses using macro-level data on 34 countries over a four year time period (2002-2005). We find that a country's outward foreign direct investment as well as its export and import positively influence entrepreneurs export orientation. We also find that the extent to which a country's entrepreneurs engage in export-oriented activities affects the subsequent emergence of new businesses within the country's borders. We discuss our findings, and point to the study's implications, limitations and future research possibilities.