Alpha-glucosidase inhibitory and antioxidant activities of various extracts of aerial parts of Fagonia indica Burm. F.

Purpose: To investigate in vitro antioxidant and anti-diabetic potentials of Fagonia indica Burm.f. Var. indica in order to provide scientific evidence for its traditional use. Methods: Cold maceration method was employed for the preparation of extracts of aerial parts of the plant using chloroform, n-hexane, methanol and water as solvents. Total flavonoid and polyphenolic content of various extracts were determined by standard methods. The antioxidant and anti-diabetic activities of the extracts were determined using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) and in vitro αglucosidase (maltase) inhibitory assays, respectively. Results: Preliminary results indicated the presence of various phytochemicals in the extracts. The chloroform extract exhibited the highest contents of total flavonoids (65.98 ± 1.63 mg QE/g) and polyphenols (26.75 ± 1.09 mg GAE/g). This extract also showed the highest free radical scavenging (64.74 ± 1.43 %) with IC50 value of 34.18 ± 5.57 µg/mL while the methanol extract exerted the highest αglucosidase (maltase) inhibitory activity (45.22 ± 0.46 %) with half-maximal concentration (IC50) of 220.4 ± 0.41 µg/mL. Conclusion: The extracts of the aerial parts of Fagonia indica possess significant anti-diabetic and antioxidant effect, thus justifying the traditional use of the plant for treatment of diabetes

Post-Traumatic Syringomyelia: A Case Series

It is relatively common to occur in a Tertiary Care Neurosurgical setup to get a case of Syringomyelia proximal or distal to a space-occupying lesion (SOL) or site of spinal cord compression. In this case series, we are presenting two cases in which syringomyelia developed after traumatic spinal cord injury. On initial radiological investigations, the first case presented as an old D12 fracture with Post-traumatic syrinx formation but on complete workup for the extent of the syrinx, another lesion was found incidentally in the form of an intradural extramedullary SOL at the level of cervicomedullary junction. The SOL turned out histologically as WHO Grade I Meningioma. The second case presented as syrinx formation after gunshot (fire-arm) penetrating spinal cord injury to the D11-12 vertebrae. Treatment plans of both these patients are presented here in detail along with the literature review

1-(4-Hydr­oxy-2-methyl-1,1-dioxo-2H-1,2-benzothia­zin-3-yl)ethanone

In the title compound, C11H11NO4S, the thia­zine ring adopts a distorted half-chair conformation. The enolic H atom is involved in an intra­molecular O—H⋯O hydrogen bond, forming a six-membered ring. Mol­ecules are linked through weak inter­molecular C—H⋯O hydrogen bonds, resulting in chains lying along the b axis

N′-(2,4-Dinitro­phen­yl)acetohydrazide

In the title compound, C8H8N4O5, the nitro groups ortho and para to the hydrazone group are twisted by 10.0 (2) and 3.6 (2)°, respectively, relative to the aromatic ring. The structure exhibits an intra­molecular N—H⋯O hydrogen bond between the hydrazide and ortho-nitro groups. There is a strong inter­molecular C=O⋯H—N hydrogen bond, giving rise to chains, and weaker ONO⋯NO2 [2.944 (2) Å] and C—H⋯O—N inter­actions linking the mol­ecules into a three-dimensional network

N′-(3-Methoxy­benzyl­idene)-4-nitro­benzohydrazide monohydrate

There are two independent formula units in the asymmetric unit of the title compound, C15H13N3O4·H2O. The C=C—N—C torsion angle of the methyl­idenehydrazide group is 174.3 (2)° in one mol­ecule and 178.6 (2)° in the other. The dihedral angles between the two benzene rings in the two mol­ecules are 4.17 (12) and 3.58 (12)°. In the crystal structure, inter­molecular O—H⋯O, N—H⋯O and O—H⋯N hydrogen bonds link the components into a two-dimensional network and additional stabilization is provided by weak inter­molecular C—H⋯O hydrogen bonds

Methyl 2-methyl-4-(oxiran-2-ylmeth­oxy)-2H-1,2-benzothia­zine-3-carboxyl­ate 1,1-dioxide

In the title compound, C14H15NO6S, the thia­zine ring adopts a distorted half-chair conformation. The structure displays several cooperative weak inter­molecular C—H⋯O hydrogen-bonding inter­actions, giving rise to a two-dimensional sheet packing motif. The CH2 group in the meth­oxy linker to the oxirane ring, and the CH group in that ring, exhibit twofold positional disorder. The three-membered oxirane ring is twisted approximately perpendicular with respect to thia­zine ring (dihedral angle = 60/86° for the major/minor disorder components). 1,2-Benzothia­zines of this kind have a wide range of biological activities and are mainly used as medicines in the treatment of inflammation and rheumatoid arthritis

Synthesis and characterization of CoFe2O4/MWCNTs nanocomposites and high-frequency analysis of their dielectric properties.

Nanoparticles of CoFe2O4 were synthesized by chemical co-precipitation method. The CoFe2O4/MWCNT nanocomposites were synthesized with increasing contents of MWCNTs, i.e., 0.0, 2.0, 3.0, and 5.0% by weight via ultrasonication method in a dispersive medium using ortho-xylene. The synthesized cobalt ferrite nanoparticles and their nanocomposites were characterized by impedance analyzer, Fourier-transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), and x-ray diffraction (XRD) techniques. The XRD indexed patterns confirmed the face-centered cubic structure of CoFe2O4/MWCNT nanocomposites. The average crystallite size in all the samples was in the range of 15 to 35 nm. The decorations of CoFe2O4 on MWCNTs were confirmed by SEM images. The FTIR results showed two vibrational bands. With the increasing contents of multi-walled carbon nanotubes in the cobalt ferrite/MWCNT nanocomposites, the dielectric properties were also enhanced. At 1 MHz, dielectric constant, dielectric loss, and tangent loss factor were increased from 26, 15.1, and 0.580 for pure cobalt ferrite to 47, 28.9, and 0.614 for loading of 5% MWCNTs, respectively. At 1 GHz, dielectric constant, dielectric loss, and tangent loss factor were increased from 11.6, 0.33, and 0.028 for pure cobalt ferrite to 19.4, 0.61, and 0.031 for loading of 5% MWCNTs, respectively. Such a huge increase in the dielectric properties of cobalt ferrite and multi-walled carbon nanocomposites exploited their applications at high frequency

4-Nitro-N′-[(E)-3-pyridylmethyl­idene]benzohydrazide

In the title moleclue, C13H10N4O3, the methyl­idene–hydrazide [–C(=O)—N—N=C–] fragment is essentially planar, with a maximum deviation of 0.0228 (7) Å. The mean planes of the benzene and pyridine rings make dihedral angles of 25.44 (6) and 5.47 (7)°, respectively, with the mean plane of the methyl­idene–hydrazide fragment. In the crystal structure, inter­molecular N—H⋯N hydrogen bonds link mol­ecules into chains along the b axis. Additional stabilization is provided by weak inter­molecular C—H⋯O hydrogen bonds. The O atoms of the nitro group are disordered over two sets of sites of equal occupancy

2-(3,4-Dimethyl-5,5-dioxo-2H,4H-pyrazolo­[4,3-c][1,2]benzothia­zin-2-yl)acetic acid

In the title mol­ecule, C13H13N3O4S, the heterocyclic thia­zine ring adopts a half-chair conformation in which the S and an adjacent C atom are displaced by 0.919 (3) and 0.300 (4) Å, respectively, on the same side of the mean plane formed by the remaining ring atoms. The mean planes of the benzene and pyrazole rings are inclined at a dihedral angle of 18.32 (12)° with respect to each other. The acetate group is oriented at 80.75 (8)° with respect to the pyrazole ring. The crystal structure is stabilized by O—H⋯N and C—H⋯O hydrogen bonds, resulting in fused eight- and seven-membered rings with R 2 2(8) and R 2 2(7) graph-set motifs, respectively

N′-[(E)-1-(4-Bromo­phen­yl)ethyl­idene]-4-hy­droxy-2-methyl-1,1-dioxo-2H-1,2-benzothia­zine-3-carbohydrazide

The six-membered heterocycle in the title compound, C18H16BrN3O4S, adopts a sofa conformation. Intra­molecular N—H⋯N and O—H⋯O hydrogen bonds stabilize the mol­ecular conformation by forming a five- and a six-membered ring, respectively. The crystal packing is stabilized by inter­molecular C—H⋯O hydrogen bonds