Rischio occupazionale di mieloma multiplo: risultati dello studio EPILYMPH

This multicentre European case-control study evaluates occupational risk of multiple myeloma (MM) in 277 MM cases and 1108 matched controls, using logistic regression analysis and adjusting by age, gender, study centre and education. An increase in MM risk was observed for general farmers, cleaners, telephone and radio operators, and printers. Pesticide exposure lasting ten years or more, but not exposure to solvents, was also associated with an elevated MM risk (OR=I.62; 95% CI 1.01 - 2.58). Our results confirm an association of multiple myeloma with farm work, and particularly with prolonged exposure to pesticides

Lymphoma risk among animal breeders

Objectives Occupational contact with breeding animals might be implicated in lymphoma aetiology. Methods In 1998–2003, 2337 incident lymphoma cases and 2434 controls participated in the EPILYMPH case-control study in six European countries. A detailed occupational history was collected in cases and controls, including species of breeding animals, their approximate number, and circumstances of contact. We conducted a preliminary analysis on ever exposed to contact with breeding animals, and we stratifi ed the analysis by age at fi rst exposure, whether before or after 12. The OR and its 95% CI was calculated with unconditional logistic Downloaded from oem.bmj.com on July 12, 2012 - Published by group.bmj.com Abstracts Occup Environ Med 2011;68(Suppl 1):A1–A127 A35 regression for all lymphomas, and its major subtypes, adjusting by age, gender, and education. Results Lymphoma risk (all subtypes combined) did not increase among those exposed to contact with breeding animals (OR = 1.0, 95% CI 0.8 to 1.2). Risk of DLBCL was signifi - cantly lower among subjects employed in poultry farms (OR = 0.6, 95% CI 0.4 to 1.0). This inverse association was observed among subjects who started exposure before or at age 12 (OR = 0.5, 95% CI 0.2 to 1.1), but not later. Conclusions Early occupational contact with poultry might be associated with a decrease in risk of specifi c lymphoma subtypes

Lymphoma risk in animal breeders

Introduction. Occupational contact with breeding animals might be implicated in lymphoma etiology. Methods. In 1998-2003, 2337 incident lymphoma cases and 2434 controls participated in the EPILYMPH case-control study in six European countries. A detailed occupational history was collected in cases and controls, including species of breeding animals, their approximate number, and circumstances of contact. We conducted a preliminary analysis on ever exposed to contact with breeding animals, and we stratified the analysis by age at first exposure, whether before or after age 12. The Odds ratio (OR) and its 95% confidence interval (95% CI) was calculated with unconditional logistic regression for all lymphomas, and its major subtypes, adjusting by age, gender, and education. Results. Lymphoma risk (all subtypes combined) did not increase among exposed to contact with breeding animals (OR = 1.0, 95% CI 0.8 -1.2). Risk of DLBCL was significantly lower among subjects employed in poultry farms (OR = 0.6, 95% CI0.4 -1.0). This inverse association was observed among subjects who starter exposure before or at age 12 (OR = 0.5, 95% CI 0.2 -1.1), but not later. Conclusion. Early occupational contact with poultry might be associated with a decrease in risk of specific lymphoma subtypes

Rischio di linfoma associato al contatto occupazionale con animali dall’allevamento

Introduction. Occupational contact with breeding animals might be implicated in the etiology of lymphoma. Methods. In 1998-2003, 2337 incident lymphoma cases and 2434 controls participated in the EPILYMPH case-control study in six European countries. A detailed occupational history was collected in cases and controls, including species of breeding animals, their approximate number, and circumstances of contact. We conducted a preliminary analysis on ever exposed to contact with breeding animals, and we stratified the analysis by age at first exposure, whether before or after 12. The Odds ratio (OR) and its 95% confidence interval (95% CI) was calculated with unconditional logistic regression for all lymphomas, and its major subtypes, adjusting by age, gender, and education. Results. Lymphoma risk (all subtypes combined) did not increase among exposed to contact with breeding animals (OR = 1.0, 95% CI 0.8 -1.2). Risk of DLBCL was significantly lower among subjects employed in poultry farms (OR = 0.6, 95% CI0.4 -1.0). This inverse association was observed among subjects who starter exposure before or at age 12 (OR = 0.5, 95% CI 0.2 -1.1), but not later. Conclusion. Early occupational contact with poultry might be associated with a decrease in risk of specific lymphoma subtypes

Lymphoma risk and occupational exposure to pesticides: results of the EPILYMPH study

Objectives Several agricultural pesticides have shown a carcinogenic potential in experimental animals. Methods In 1998–2003, 2337 incident lymphoma cases and 2434 controls participated in the EPILYMPH case-control study in six European countries. A detailed occupational history was collected in cases and controls. Specific questions for farm workers included type of crop, farm size, pests being treated,type and schedule of pesticide use. We conducted a preliminary analysis of risk of lymphoma and its major subtypes associated with occupational exposure to groups of pesticides. The OR and its 95% CI was calculated with unconditional logistic regression for all lymphomas, and its major subtypes, adjusting by age, gender, and education. Results Lymphoma risk did not increase among those exposed to inorganic (OR = 1.3, 95% CI 0.9 to 1.7) or organic pesticides (OR = 1.1, 95% CI 0.9 to 1.4). Risk of CLL was signifi cantly increased among those exposed to pesticides (OR = 1.5 95% CI 1.0 to 2.2), and particularly to organophosphates (OR = 2.2, 95% CI 1.1 to 4.4). No other signifi cant associations were observed. Conclusions Our results confi rm previous reports of an increase in risk of specifi c lymphoma subtypes associated with exposure to specifi c agrochemicals

Rischio di linfoma associato all’esposizione a pesticidi in agricoltura: risultati preliminari dello studio Epilymph

Introduction. Several agricultural pesticides have shown a carcinogenic potential in experimental animals. Methods. In 1998-2003, 2337 incident lymphoma cases and 2434 controls participated in the EPILYMPH case-control study in six European countries. A detailed occupational history was collected in cases and controls. Specific questions for farm workers included type of crop, farm size, pests being treated, type and schedule of pesticide use. We conducted a preliminary analysis of risk of lymphoma and its major subtypes associated with occupational exposure to groups of pesticides. The Odds ratio (OR) and its 95% confidence interval (95% CI) was calculated with unconditional logistic regression for all lymphomas, and its major subtypes, adjusting by age, gender, and education. Results. Lymphoma risk did not increase among exposed to inorganic (OR = 1.3, 95% CI 0.9 -1.7) or organic pesticides (OR = 1.1, 95% CI 0.9 -1.4). Risk of CLL was significantly increased among exposed to organophosphates (OR = 2.2, 95% CI 1.1 -4.4). No other significant association were observed. Conclusion. Our results confirm previous reports of an increase in risk of specific lymphoma subtypes associated with exposure to specific agrochemicals

Lymphoma risk and occupational exposure to pesticides: results of the epilymph study

Introduction. Several agricultural pesticides have shown a carcinogenic potential in experimental animals. Methods. In 1998-2003, 2337 incident lymphoma cases and 2434 controls participated in the EPILYMPH case-control study in six European countries. A detailed occupational history was collected in cases and controls. Specific questions for farm workers included type of crop, farm size, pests being treated, type and schedule of pesticide use. We conducted a preliminary analysis of risk of lymphoma and its major subtypes associated with occupational exposure to groups of pesticides. The Odds ratio (OR) and its 95% confidence interval (95% CI) was calculated with unconditional logistic regression for all lymphomas, and its major subtypes, adjusting by age, gender, and education. Results. Lymphoma risk did not increase among exposed to inorganic (OR = 1.3, 95% CI 0.9 -1.7) or organic pesticides (OR = 1.1, 95% CI 0.9 -1.4). Risk of CLL was significantly increased among exposed to pesticides (OR = 1.5 95% CI 1.0 - 2.2), and particularly to organophosphates (OR = 2.2, 95% CI 1.1 - 4.4). No other significant association were observed. Conclusion. Our results confirm previous reports of an increase in risk of specific lymphoma subtypes associated with exposure to specific agrochemicals