Trust Model for Optimized Cloud Services

Cloud computing with its inherent advantages draws attention for business critical applications, but concurrently expects high level of trust in cloud service providers. Reputation-based trust is emerging as a good choice to model trust of cloud service providers based on available evidence. Many existing reputation based systems either ignore or give less importance to uncertainty linked with the evidence. In this paper, we propose an uncertainty model and define our approach to compute opinion for cloud service providers. Using subjective logic operators along with the computed opinion values, we propose mechanisms to calculate the reputation of cloud service providers. We evaluate and compare our proposed model with existing reputation models

ASSESSMENT OF ANTINEOPLASTIC POTENTIAL OF ANNONA RETICULATA LINN. ON HUMAN CANCER CELL LINES

ABSTRACTObjective: The present study was undertaken to establish the antineoplastic potential of Annona reticulata on human cancer cell lines, viz., squamouscell carcinoma 9 (SCC9), MCF-7 (human breast adenocarcinoma), A549 (lung adenocarcinoma), and HCT116 (colorectal carcinoma) cells.Methods: The study was performed through MTT, cell cycle (G2M), and DNA fragmentation assays. Cells inhibited in MTT assay were subjected to cellcycle analysis and DNA fragmentation, respectively.Results: The extracts showed dose-dependent growth inhibition of SCC9, MCF-7, A549, and HCT116 cells. In contrast to HCT116 and A549 cells,which exhibited cytotoxicity at a higher concentration with IC50 value of 271.7 and 296 µg/ml, the extract treated SCC9 and MCF-7 cells exhibitedsignificant cytotoxicity at a lower concentration with IC50 value of 49.47 and 52.65 µg/ml, respectively. The treated A549 and MCF-7 cells showed cellcycle arrest up to 7.07% and 14.42%, respectively, at G2/M phase of cell cycle. DNA fragmentation was not observed in both A549 and MCF-7 cellstreated with A. reticulata extract at a concentration of 320 µg/ml.Conclusion: Encouraging preliminary results emphasize the necessity for further research on characterization of individual compounds from thisextract and advocate it as a good source of anticancer agent for certain types of cancer.Keywords: Annona reticulata, Anticancer activity, MTT, G2M and DNA fragmentation

E-mail address categorization based on semantics of surnames

Surname (family name) analysis is used in geography to understand population origins, migration, identity, social norms and cultural customs. Some of these are supposedly evolved over generations. Surnames exhibit good statistical properties that can be used to extract information in names data set such as automatic detection of ethnic or community groups in names. An e-mail address, often contains surname as a substring. This containment may be full or partial. An e-mail address categorization based on semantics of surnames is the objective of this paper. This is achieved in two phases. First phase deals with surname representation and clustering. Here, a vector space model is proposed where latent semantic analysis is performed. Clustering is done using the method called averagelinkage method. In the second phase, an email is categorized as belonging to one of the categories (discovered in first phase). For this, substring matching is required, which is done in an efficient way by using suffix tree data structure. We perform experimental evaluation for the 500 most frequently occurring surnames in India and United Kingdom. Also, we categorize the e-mail addresses that have these surnames as substrings

Analytical study of Fifty Cases of Colorectal Malignancies

INTRODUCTION: Colorectal cancers though most common in the west are on the increase in our country for the past decade. The early detection of the disease is of paramount important in its out come few topics in cancer research have engendered more excitement, the recent discovery of identifiable genetic defect in patients with inherited as well as sporadic form of colorectal cancer. AIM OF STUDY: To study the pattern of: 1. Incidence, Age, Sex and site. 2. Etiopathogenesis. 3. Clinical presentation. 4. Treatment modalities. 5. Adjuvant therapy. 6. Role of minimal access surgery. 7. Recent advances in management. 8. Follow up of colorectal carcinoma in Govt. Royapettah Hospital, Chennai. MATERIALS AND METHODS: Cases of colorectal carcinomas collected during the period of September 2004 to August 2006 of 24 months are utilized for this Study. A total No. of 50 cases of which 8 presented as Emergencies. Detailed history was elicited from each patient with special preferences to family history habitations and early symptomatology. Thorough physical examination was performed for evaluation of General condition, detection of signs and per rectal examination for all patients. Thorough lab investigation were done in every patient except those who presented Emergencies underwent contrast radiographic studies. Colonoscopic evaluation and CT abdomen done in selected cases. Chest x-rays taken for all patients for preoperative evaluation as well as detection of secondaries. Liver function test done as a routine test to assess nutritional status of patient. For all possible cases, preoperative biopsy taken via proctoscopic, colonoscopic guidance and histologic type made out before planning treatment. Detailed Histopathological reports were available for staging tumor and assessing the grade differentiation. CONCLUSION: 1. Incidence of colorectal carcinoma is on the increase in the past few years. 2. There is no definitive evidence to say that diet rich in fat is risk factor. 3. Commonest age group of colorectal carcinoma was 5 - 6th decade, (middle age and elderly age). 4. The incidence was slightly higher in male M : F 1:5:1. 5. Ca rectum was most common site of large bowel in this study (46%). There is also an increase incidence on the right side of colon (36%). 6. More patient presented to us with advanced stage considering bleeding PR and altered bowel habits as Haemorrhoids, as it is known by that only 2% of patient presented in Duckes Stage A. 7. 16% of patient presented with acute emergency in the form of intestitnal obstruction. 8. Surgery is the main modality of treatment which is palliative or curative. 9. To conclude any patient of middle and elderly age group who presenting with bleeding PR and altered bowel habits should be investigated thoroughly with per rectal, proctoscopic or sigmoidoscopic examination. Patient presenting with advanced stage had poor prognosis. 10. Role of minimal access surgery in colorectal malignancy is vital as in upgrading stage, less morbid procedure, early recovery to work etc. 11. Hence patients must be educated about the symptom and etiology of colorectal malignancy and importance of screening in those with family history, in order to get a earlier treatment and better outcome for both the surgeon and patient alike

Study of breast lesions in cytology and its histopathological correlation

Background: Breast cancer is commonly diagnosed malignancy in females and is leading cause of death. Malignant lesions mostly occur after menopause. Fine needle aspiration cytology is minimally invasive technique, used in triple test and produces speedy results. It can able to differentiate between benign and malignant lesions of breast lump. Our study aims to categorize the breast lesion and to correlate FNAC with histopathological studies. Methods: This retrospective study was done in department of pathology from July 2021 to May 2023.107 cases were undergone FNAC and slides were examined and lesions were categorized. Tissue biopsies were obtained, processed and histological sections were made and examined. The FNAC findings were correlated and analyzed with histological findings. Results: Right breast lesions (55%) were more in our study than left breast lesions (42%). Totally 77 cases were diagnosed as benign lesions by FNAC of which 37 cases were biopsied and histological diagnosis of all cases shown as benign category. 6 cases were diagnosed as proliferative breast disease with atypia of which only one case was received for biopsy and diagnosed as atypical ductal hyperplasia. 12 cases were diagnosed as malignancy and 6 biopsies were received with 5 cases were diagnosed as malignant lesions. Sensitivity and Specificity of FNAC in breast lesions were 100% and 97.43% respectively. Conclusions: FNAC is rapid and valuable tool with high sensitivity, specificity and low false positivity. It is useful in preoperative evaluation and avoids unnecessary surgical intervention

Effects of Intralesional Triamcinalone Injection following Internal Urethrotomy for treatment of Stricture Urethra: A Prospective Analytical Experimental study

INTRODUCTION : stricture disease of urethra is always a challenge for almost all practicing urologists. Treatment optins available such as dilatation, DVIU , placement of stent, single or various stages of urethroplasty. Management by endoscopy is routinely done first for short bulbar urethral strictures before other modality of treatment. The reported success rate of single DVIU is 20 to 60 %. DVIU don’t produce epithelial approximation but it separates scarred epithelium so ,wound heals by secondry intention. If wound contraction takes place before full epithelialisation, it significantly narrows lumen and result in recurrence. Injection of steroid triamcinalone intralesionally following internal urethrotomy , decrease formation of scar by enhancing endogenous production of collagenase and obviates scar formation. In our study we analysed the outcome of injection of steroid (triamcinalone)& urethral stricture recurrence after DVIU. We analysed time duration between VIU and urethral stricture disease recurrence. AIM OF THE STUDY : 1. To study the effect of triamcinalone acetate injected intralesionally in patients undergoing internal urethrotomy (DVIU) for anterior urethral strictures. 2. To collect short term data on the need for self calibration or dilatation and other adjuvant procedures in those patients in one year. MATERIALS AND METHODS : It is a prospective study conducted in our institution from January2013 to February 2014.After receiving ethical committee approval from our institution , around 50 patients with stricture of urethra who are symptomatic and presenting at our hospital were selected . This was a prospective experimental study. 50 patients of stricture urethra who are symptomatic ,presenting at our hospital were segregated into two groups 25 in each containing group.The experimental Group (D) were treated by cold knife internal urethrotomy with intralesional triamcinolone injection while the control group (C) treated with urethrotomy alone. Postoperative results were compared between two groups. Inclusion Criteria : 1. Anterior urethral stricture 2cm, 3. Neurogenic bladder, 4. History of systemic or immune disease, 5. Patients already on steroids, 6. Patient refusal. CONCLUSION : From our study we conclude that injection of steroid triamcinalone following internal urethrotomy decrease the recurrence rate of stricture as well as delays the time to recurrence when compared to internal urethrototmy alone for the treatment of short segment urethral strictures (<2cm). To achieve curative and long-term effects, this technique of injection of steroid following internal urethrotomy has to be conducted on a large group of patients with long duration of follow up and special emphasis on objective verification of the safety and efficacy profile. Injection of steroid at stricture site can be considered as safe and effective adjuvant modality after internal urethrotomy

Towards Transparency of IoT Message Brokers

In this paper we propose an ontological model for documenting provenance of MQTT message brokers to enhance the transparency of interactions between IoT agents