2 research outputs found
A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis: a EUSTAR exploratory study
Objective: Qualitative capillaroscopy patterns in juvenile- and adult-onset systemic sclerosis (SSc) were studied
in adulthood using data from the EULAR Scleroderma Trials and Research (EUSTAR) database.
Methods: Data collected between June 2004 and April 2013 were examined with focus on capillaroscopy. In
this retrospective exploratory study, series of patients with juvenile-onset SSc were matched with series of
adult-onset SSc having the same gender and autoantibody profile.
Results: 30 of 123 patientswith juvenile-onset and 2108 of 7133with adult-onset SSc had data on capillaroscopy.
Juvenile-onset SSc showed scleroderma pattern more frequently than adult-onset SSc (93.3% and 88%). The OR
was 2.44 and 95% CI 0.57–10.41. An active scleroderma pattern was present in 58% of juvenile- and 61% of
adult-onset SSc. The OR was 0.91 and 95% CI 0.28–2.93. The late scleroderma pattern was present in 61% of
juvenile- and 55.5% of adult-onset SSc. The OR was 1.06 and 95% CI 0.34–3.56.
Conclusion: This is the first exploratory study on the comparison of capillaroscopy between juvenile- and
adult-onset SSc in adulthood. Juvenile-onset SSc had an increase prevalence of scleroderma pattern, but a similar
distribution of the three patterns was suggested. Further studies are needed to define this issue.
© 2015 Elsevier Inc. All rights reserved