2 research outputs found
Effects of Mesenchymal Stem Cell Derivatives on Hematopoiesis and Hematopoietic Stem Cells
Hematopoiesis
is a balance among quiescence, self-renewal, proliferation, and
differentiation, which is believed to be firmly adjusted through interactions
between hematopoietic stem and progenitor cells (HSPCs) with the
microenvironment. This microenvironment is derived from a common progenitor of
mesenchymal origin and its signals should be capable of regulating the cellular
memory of transcriptional situation and lead to an exchange of stem cell genes
expression. Mesenchymal stem cells (MSCs) have self-renewal and differentiation
capacity into tissues of mesodermal origin, and these cells can support
hematopoiesis through release various molecules that play a crucial role in
migration, homing, self-renewal, proliferation, and differentiation of HSPCs. Studies
on the effects of MSCs on HSPC differentiation can develop modern solutions in
the treatment of patients with hematologic disorders for more effective Bone
Marrow (BM) transplantation in the near future. However, considerable
challenges remain on realization of how paracrine mechanisms of MSCs act on the
target tissues, and how to design a therapeutic regimen with various paracrine
factors in order to achieve optimal results for tissue conservation and
regeneration. The aim of this review
is to characterize and consider the related aspects of the ability of MSCs
secretome in protection of hematopoiesis
The Impact of Mesenchymal Stem Cells on Differentiation of Hematopoietic Stem Cells
Bone marrow microenvironment contains cellular and
acellular compartments. The cellular compartment includes hematopoietic stem
cells, mesenchymal stem cells and some other stromal cell types, while the
acellular compartment is composed of scaffold proteins known as the extra
cellular matrix. Direct cell-cell contact as well as cytokines secreted by
mesenchymal stem cells during coculture of hematopoietic stem cells and
mesenchymal stem cells play a critical role in hematopoiesis, and determines
the fate of hematopoietic stem cells. Several studies have demonstrated the
impact of mesenchymal stem cells on self-renewal, expansion, proliferation and differentiation
of hematopoietic stem cells in vitro, which have shown different and
contradictory results. In this paper, we will investigate the effect of
mesenchymal stem cells on differentiation of hematopoietic stem cells in vitro