20 research outputs found
Circumventing antivector immunity: potential use of nonhuman adenoviral vectors
Adenoviruses are efficient gene delivery vectors based on their ability to transduce a wide variety of cell types and drive high-level transient transgene expression. While there have been advances in modifying human adenoviral (HAdV) vectors to increase their safety profile, there are still pitfalls that need to be further addressed. Preexisting humoral and cellular immunity against common HAdV serotypes limits the efficacy of gene transfer and duration of transgene expression. As an alternative, nonhuman AdV (NHAdV) vectors can circumvent neutralizing antibodies against HAdVs in immunized mice and monkeys and in human sera, suggesting that NHAdV vectors could circumvent preexisting humoral immunity against HAdVs in a clinical setting. Consequently, there has been an increased interest in developing NHAdV vectors for gene delivery in humans. In this review, we outline the recent advances and limitations of HAdV vectors for gene therapy and describe examples of NHAdV vectors focusing on their immunogenicity, tropism, and potential as effective gene therapy vehicles
Measurement of ratio using stopped positive kaons
The ratio of the () and () decay widths, , has been measured with stopped positive kaons.
and samples containing 2.4 and 4.0 events, respectively, were analyzed. The
ratio was obtained to be
0.6710.007(stat.)0.008(syst.) calculating the detector acceptance by
a Monte Carlo simulation with the assumption of - universality in
decay. The coefficient of the dependent term of the form
factor was also determined to be
=0.0220.005(stat.)0.004(syst.).Comment: 12 pages, 6 figure