The variation of air and surface temperatures in London within a 1km grid using vehicle-transect and ASTER data

Urbanisation can modify the local climate, increasing the temperature of cities compared to rural areas. This phenomenon is known as the Urban Heat Island (UHI), and this paper introduces a methodology to investigate the spatial variability of air and surface temperatures across London. In particular, this study aims to investigate if a widely used spatial resolution (1 km) is appropriate for heat-related health risk studies. Data from vehicle-transect and ASTER thermal images were overlaid on a reference grid of 1 km, used by UHI simulation models. The results showed higher variability of air temperature within some specific modelled grid cells in the city centre, while surface temperatures presented higher variability in the London borders. This investigation suggests that LST has larger variation levels and more grid cells with sub-grid variation above 1°C compared to air temperature measurements

Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic α and β cells

This is the final version of the article. Available from eLife Sciences Publications via the DOI in this record.Type 1 diabetes (T1D) is an autoimmune disease caused by loss of pancreatic β cells via apoptosis while neighboring α cells are preserved. Viral infections by coxsackieviruses (CVB) may contribute to trigger autoimmunity in T1D. Cellular permissiveness to viral infection is modulated by innate antiviral responses, which vary among different cell types. We presently describe that global gene expression is similar in cytokine-treated and virus-infected human islet cells, with up-regulation of gene networks involved in cell autonomous immune responses. Comparison between the responses of rat pancreatic α and β cells to infection by CVB5 and 4 indicate that α cells trigger a more efficient antiviral response than β cells, including higher basal and induced expression of STAT1-regulated genes, and are thus better able to clear viral infections than β cells. These differences may explain why pancreatic β cells, but not α cells, are targeted by an autoimmune response during T1D.Fonds De La Recherche Scientifique – FNRS: FNRS- F 5/4/5.MCF/KP. Project de secherche (PDR) T.0036.13; European Commission (EC): Projects Naimit and BetaBat, in the Framework Programme 7 of the European Community; Federation Wallonie- Bruxelles: the Communaute Franc¸ aise de BelgiqueActions de Recherche Concertees (ARC); Fonds De La Recherche Scientifique – FNRS: FNRS post-doctoral fellowship; Governo Brasil: PDE/CSF Pos-Doutorado no Exterior; Juvenile Diabetes Research Foundation International (JDRF): JDRF Career Development Award; European Commission (EC): European Union’s Seventh Framework Programme [FP7/2007-2013] under grant agreement 261441 PEVNE

Toward Content-Driven Intelligent Authoring of Mulsemedia Applications

Improvement of Higher Education Personnel—Brazil; 10.13039/501100004586-Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; 10.13039/501100003593-Conselho Nacional de Desenvolvimento Científico e Tecnológico; CAPES PRINT