A pulsational distance to Omega Centauri based on Near-Infrared Period-Luminosity relations of RR Lyrae stars

We present new Near-Infrared (J,K) magnitudes for 114 RR Lyrae stars in the globular cluster Omega Cen (NGC 5139) which we combine with data from the literature to construct a sample of 180 RR Lyrae stars with J and K mean magnitudes on a common photometric system. This is presently the largest such sample in any stellar system. We also present updated predictions for J,K-band Period-Luminosity relations for both fundamental and first-overtone RR Lyrae stars, based on synthetic horizontal branch models with metal abundance ranging from Z=0.0001 to Z=0.004. By adopting for the Omega Cen variables with measured metal abundances an alpha-element enhancement of a factor of 3 (about 0.5 dex) with respect to iron we find a true distance modulus of 13.70 (with a random error of 0.06 and a systematic error of 0.06), corresponding to a distance d=5.5 Kpc (with both random and systematic errors equal to 0.03 Kpc). Our estimate is in excellent agreement with the distance inferred for the eclipsing binary OGLEGC-17, but differ significantly from the recent distance estimates based on cluster dynamics and on high amplitude Delta Scuti stars.Comment: 24 pages, 7 figures, accepted for publication on The Astrophysical Journa

When Viruses Meet Fungi: Tackling the Enemies in Hematology

The association of invasive fungal infections (IFI) and viral infections has been described in patients with hematologic malignancies (HM), in particular in hematopoietic stem cell transplant recipients. Regrettably, the diagnosis is often challenging, making the treatment inappropriate in some circumstances. The present review takes into consideration the viral infections commonly associated with IFI. Clinical presentation of IFI and viral infections, risk factors, and impact on the outcome of HM patients are discussed throughout the paper

Immunotherapy as a turning point in the treatment of acute myeloid leukemia

Acute myeloid leukemia (AML) is a malignant disease of hematopoietic precursors at the earliest stage of maturation, resulting in a clonalproliferation of myoblasts replacing normal hematopoiesis. AML represents one of the most common types of leukemia, mostly affecting elderly patients. To date, standard chemotherapy protocols are only effective in patients at low risk of relapse and therapy-related mortality. The average 5-year overall survival (OS) is approximately 28%. Allogeneic hematopoietic stem cell transplantation (HSCT) improves prognosis but is limited by donor availability, a relatively young age of patients, and absence of significant comorbidities. Moreover, it is associated with significant morbidity and mortality. However, increasing understanding of AML immunobiology is leading to the development of innovative therapeutic strategies. Immunotherapy is considered an attractive strategy for controlling and eliminating the disease. It can be a real breakthrough in the treatment of leukemia, especially in patients who are not eligible forintensive chemotherapy. In this review, we focused on the progress of immunotherapy in the field of AML by discussing monoclonal antibodies (mAbs), immune checkpoint inhibitors, chimeric antigen receptor T cells (CAR-T cells), and vaccine therapeutic choices

B, V, I photometry of the complete sample of 23 Cepheids in the field of NGC 1866

We present the result of BVI photometry, obtained by using FORS@VLT, of the Cepheids present in the field of the Large Magellanic Cloud cluster NGC 1866. We found the 22 known variables plus an additional new Cepheid located about 10' from the cluster center. The accuracy of the photometry allowed us to derive B, V and I mean magnitudes with an uncertainty lower than 0.02 mag for 22 out of the 23 objects, with the exception of only one Cepheid (WS9) which presents a noisy light curve due to the probable occurrence of image blending. As a result, we provide accurate observational data for a substantial sample of variables all lying at the same distance and with a common original composition. The resulting period-luminosity relations are presented and briefly discussed.Comment: 4 pages, 6 figure, to appear in the proceedings of the Workshop "Stellar pulsation and evolution", 2005. Monte Porzio Catone, Italy. Eds.: A. R. Walker and G. Bon

On the distance and reddening of the starburst galaxy IC10

We present deep and accurate optical photometry of the Local Group starburst galaxy IC10. The photometry is based on two sets of images collected with the Advanced Camera for Surveys and with the Wide Field Planetary Camera 2 on board the Hubble Space Telescope. We provide new estimates of the Red Giant Branch tip (TRGB) magnitude, m_{F814W}^{TRGB}=21.90+-0.03, and of the reddening, E(B-V)=0.78+-0.06, using field stars in the Small Magellanic Cloud (SMC) as a reference. Adopting the SMC and two globulars, Omega Centauri and 47 Tucanae, as references we estimate the distance modulus to IC10: independent calibrations give weighted average distances of mu=24.51+-0.08 (TRGB) and mu=24.56+-0.08 (RR Lyrae). We also provide a new theoretical calibration for the TRGB luminosity, and using these predictions we find a very similar distance to IC10 (mu~24.60+-0.15). These results suggest that IC10 is a likely member of the M31 subgroup.Comment: 4 pages, 4 figures, ApJ Letters accepte

Star Counts in the Globular Cluster Omega Centauri. I. Bright Stellar Components

We present an extensive photometry on HB, RGB, and MSTO stars in Omega Cen. The central regions of the cluster were covered with a mosaic of F435W, F625W, and F658N-band data collected with ACS/HST. The outer reaches were covered with a large set of U,B,V,I-band data collected with the [email protected] ESO/MPI telescope. The final catalogue includes ~1.7 million stars. We identified ~3,200 likely HB stars and ~12,500 stars brighter than the subgiant branch and fainter than the RGB bumps. The HB morphology changes with the radial distance. The relative number of extreme HB stars decreases from ~30% to ~21% when moving from the center toward the outer regions of the cluster, while the fraction of less hot HB stars increases from ~62% to ~72%. We performed a detailed comparison between observed ratios of different stellar tracers and predictions based on canonical evolutionary models with a primordial helium (Y=0.23) content and metal abundances (Z=0.0002,0.001) that bracket the observed spread in metallicity of Omega Cen stars. We found that the empirical star counts of HB stars are on average larger (30%-40%) than predicted. Moreover, the rate of HB stars is 43% larger than the MSTO rate. The discrepancy between the rate of HB compared with the rate of RG and MSTO stars supports the evidence that we are facing a true excess of HB stars. The same comparison was performed by assuming a mix of stellar populations made with 70% of canonical stars and 30% of He-enhanced stars. The discrepancy between theory and observations decreases by a factor of two when compared with rates predicted by canonical He content models, but still 15%-25% (Y=0.42) and 15%-20% (Y=0.33) higher than observed. Furthermore, the ratio between HB and MSTO star counts are ~24% (Y=0.42) and 30% (Y=0.33) larger than predicted lifetime ratios.Comment: 54 pages, 17 figures,to be published in ApJ, see link at http://stellari.wiki.zoho.co

Relative distances of Omega Centauri and 47 Tucanae

We present precise optical and near-infrared ground-based photometry of two Globular Clusters (GCs): Omega Cen and 47 Tuc. These photometric catalogs are unbiased in the Red Giant Branch (RGB) region close to the tip. We provide new estimates of the RGB tip (TRGB) magnitudes--m_I(TRGB)=9.84+/-0.05, Omega Cen; m_I(TRGB)=9.46+/-0.06, 47 Tuc--and use these to determine the relative distances of the two GCs. We find that distance ratios based on different calibrations of the TRGB, the RR Lyrae stars and kinematic distances agree with each other within one sigma. Absolute TRGB and RR Lyrae distance moduli agree within 0.10--0.15 mag, while absolute kinematic distance moduli are 0.2--0.3 mag smaller. Absolute distances to 47 Tuc based on the Zero-Age-Horizontal-Branch and on the white dwarf fitting agree within 0.1 mag, but they are 0.1--0.3 mag smaller than TRGB and RR Lyrae distances.Comment: 5 pages, 4 figures, accepted for publication by ApJ

On the anomalous red giant branch of the globular cluster Omega Cen

We present three different optical and near-infrared (NIR) data sets for evolved stars in the Galactic Globular Cluster Omega Cen The comparison between observations and homogeneous sets of stellar isochrones and Zero-Age Horizontal Branches provides two reasonable fits. Both of them suggest that the so-called anomalous branch has a metal-intermediate chemical composition (-1.1 < [Fe/H] < -0.8) and is located ~500 pc beyond the bulk of Omega Cen stars. These findings are mainly supported by the shape of the subgiant branch in four different color-magnitude diagrams (CMDs). The most plausible fit requires a higher reddening, E(B-V)=0.155 vs. 0.12, and suggests that the anomalous branch is coeval, within empirical and theoretical uncertainties, to the bulk of Omega Cen stellar populations. This result is supported by the identification of a sample of faint horizontal branch stars that might be connected with the anomalous branch. Circumstantial empirical evidence seems to suggest that the stars in this branch form a clump of stars located beyond the cluster.Comment: Accepted for publication on ApJ. High resolution figures can be downloaded from ftp://ftp.mporzio.astro.it/dist/monelli2

High Incidence of Invasive Fungal Diseases in Patients with FLT3-Mutated AML Treated with Midostaurin: Results of a Multicenter Observational SEIFEM Study

The potential drug-drug interactions of midostaurin may impact the choice of antifungal (AF) prophylaxis in FLT3-positive acute myeloid leukemia (AML) patients. To evaluate the incidence of invasive fungal diseases (IFD) during the treatment of FLT3-mutated AML patients and to correlate it to the different AF prophylaxis strategies, we planned a multicenter observational study involving 15 SEIFEM centers. One hundred fourteen patients treated with chemotherapy + midostaurin as induction/reinduction, consolidation or both were enrolled. During induction, the incidence of probable/proven and possible IFD was 10.5% and 9.7%, respectively; no statistically significant difference was observed according to the different AF strategy adopted. The median duration of neutropenia was similar in patients with or without IFD. Proven/probable and possible IFD incidence was 2.4% and 1.8%, respectively, during consolidation. Age was the only risk factor for IFD (OR, 95% CI, 1.10 [1.03–1.19]) and complete remission achievement after first induction the only one for survival (OR, 95% CI, 5.12 [1.93–13.60]). The rate of midostaurin discontinuation was similar across different AF strategies. The IFD attributable mortality during induction was 8.3%. In conclusion, the 20.2% overall incidence of IFD occurring in FLT3-mutated AML during induction with chemotherapy + midostaurin, regardless of AF strategy type, was noteworthy, and merits further study, particularly in elderly patients

Reddening distribution across the center of the globular cluster Omega Centauri

We present new medium-band uvby Stromgren and broad-band VI photometry for the central regions of the globular cluster Omega Cen. From this photometry we have obtained differential reddening estimates relative to two other globular clusters (M13 and NGC288) using a metallicity-independent, reddening-free temperature index, [c]=(u-v)-(v-b) - 0.2(b-y), for hot horizontal-branch (HB) stars (T_e> 8,500K). We estimate color excesses of these hot HB stars using optical and near-infrared colors, and find clumpy extinction variations of almost a factor of two within the area of the cluster core. In particular, the greatest density of more highly reddened objects appears to be shifted along the right ascension axis when compared with less reddened ones. These findings complicate photometric efforts to investigate the star formation history of Omega Cen.Comment: 5 figures, accepted for publication by ApJ Letter