Large-scale Oscillation of Structure-Related DNA Sequence Features in Human Chromosome 21

Human chromosome 21 is the only chromosome in human genome that exhibits oscillation of (G+C)-content of cycle length of hundreds kilobases (500 kb near the right telomere). We aim at establishing the existence of similar periodicity in structure-related sequence features in order to relate this (G+C)% oscillation to other biological phenomena. The following quantities are shown to oscillate with the same 500kb periodicity in human chromosome 21: binding energy calculated by two sets of dinucleotide-based thermodynamic parameters, AA/TT and AAA/TTT bi-/tri-nucleotide density, 5'-TA-3' dinucleotide density, and signal for 10/11-base periodicity of AA/TT or AAA/TTT. These intrinsic quantities are related to structural features of the double helix of DNA molecules, such as base-pair binding, untwisting/unwinding, stiffness, and a putative tendency for nucleosome formation.Comment: submitted to Physical Review

Learning about compact binary merger: the interplay between numerical relativity and gravitational-wave astronomy

Activities in data analysis and numerical simulation of gravitational waves have to date largely proceeded independently. In this work we study how waveforms obtained from numerical simulations could be effectively used within the data analysis effort to search for gravitational waves from black hole binaries. We propose measures to quantify the accuracy of numerical waveforms for the purpose of data analysis and study how sensitive the analysis is to errors in the waveforms. We estimate that ~100 templates (and ~10 simulations with different mass ratios) are needed to detect waves from non-spinning binary black holes with total masses in the range 100 Msun < M < 400 Msun using initial LIGO. Of course, many more simulation runs will be needed to confirm that the correct physics is captured in the numerical evolutions. From this perspective, we also discuss sources of systematic errors in numerical waveform extraction and provide order of magnitude estimates for the computational cost of simulations that could be used to estimate the cost of parameter space surveys. Finally, we discuss what information from near-future numerical simulations of compact binary systems would be most useful for enhancing the detectability of such events with contemporary gravitational wave detectors and emphasize the role of numerical simulations for the interpretation of eventual gravitational-wave observations.Comment: 19 pages, 12 figure

A microfabricated sensor for thin dielectric layers

We describe a sensor for the measurement of thin dielectric layers capable of operation in a variety of environments. The sensor is obtained by microfabricating a capacitor with interleaved aluminum fingers, exposed to the dielectric to be measured. In particular, the device can measure thin layers of solid frozen from a liquid or gaseous medium. Sensitivity to single atomic layers is achievable in many configurations and, by utilizing fast, high sensitivity capacitance read out in a feedback system onto environmental parameters, coatings of few layers can be dynamically maintained. We discuss the design, read out and calibration of several versions of the device optimized in different ways. We specifically dwell on the case in which atomically thin solid xenon layers are grown and stabilized, in cryogenic conditions, from a liquid xenon bath

Characterization of Silicon Photomultipliers for nEXO

Silicon Photomultipliers (SiPMs) are attractive candidates for light detectors for next generation liquid xenon double-beta decay experiments, like nEXO. In this paper we discuss the requirements that the SiPMs must satisfy in order to be suitable for nEXO and similar experiments, describe the two test setups operated by the nEXO collaboration, and present the results of characterization of SiPMs from several vendors. In particular, we find that the photon detection efficiency at the peak of xenon scintillation light emission (175-178 nm) approaches the nEXO requirements for tested FBK and Hamamatsu devices. Additionally, the nEXO collaboration performed radioassay of several grams of bare FBK devices using neutron activation analysis, indicating levels of 40K, 232Th, and 238U of the order of <0.15, (6.9e10-4 - 1.3e10-2), and <0.11 mBq/kg, respectively.Comment: Version as accepted to Transaction of Nuclear Science. 12 pages, 15 figures (one figure removed following peer review), 8 tables (1 table added following peer review

Comparisons of binary black hole merger waveforms

This a particularly exciting time for gravitational wave physics. Ground-based gravitational wave detectors are now operating at a sensitivity such that gravitational radiation may soon be directly detected, and recently several groups have independently made significant breakthroughs that have finally enabled numerical relativists to solve the Einstein field equations for coalescing black-hole binaries, a key source of gravitational radiation. The numerical relativity community is now in the position to begin providing simulated merger waveforms for use by the data analysis community, and it is therefore very important that we provide ways to validate the results produced by various numerical approaches. Here, we present a simple comparison of the waveforms produced by two very different, but equally successful approaches--the generalized harmonic gauge and the moving puncture methods. We compare waveforms of equal-mass black hole mergers with minimal or vanishing spins. The results show exceptional agreement for the final burst of radiation, with some differences attributable to small spins on the black holes in one case.Comment: Revtex 4, 5 pages. Published versio

The theory of heating of the quantum ground state of trapped ions

Using a displacement operator formalism, I analyse the depopulation of the vibrational ground state of trapped ions. Two heating times, one characterizing short time behaviour, the other long time behaviour are found. The short time behaviour is analyzed both for single and multiple ions, and a formula for the relative heating rates of different modes is derived. The possibility of correction of heating via the quantum Zeno effect, and the exploitation of the suppression of heating of higher modes to reduce errors in quantum computation is considered.Comment: 9 pages, 2 figure

Coherent Electron-Phonon Coupling in Tailored Quantum Systems

The coupling between a two-level system and its environment leads to decoherence. Within the context of coherent manipulation of electronic or quasiparticle states in nanostructures, it is crucial to understand the sources of decoherence. Here, we study the effect of electron-phonon coupling in a graphene and an InAs nanowire double quantum dot. Our measurements reveal oscillations of the double quantum dot current periodic in energy detuning between the two levels. These periodic peaks are more pronounced in the nanowire than in graphene, and disappear when the temperature is increased. We attribute the oscillations to an interference effect between two alternative inelastic decay paths involving acoustic phonons present in these materials. This interpretation predicts the oscillations to wash out when temperature is increased, as observed experimentally.Comment: 11 pages, 4 figure

A trapped single ion inside a Bose-Einstein condensate

Improved control of the motional and internal quantum states of ultracold neutral atoms and ions has opened intriguing possibilities for quantum simulation and quantum computation. Many-body effects have been explored with hundreds of thousands of quantum-degenerate neutral atoms and coherent light-matter interfaces have been built. Systems of single or a few trapped ions have been used to demonstrate universal quantum computing algorithms and to detect variations of fundamental constants in precision atomic clocks. Until now, atomic quantum gases and single trapped ions have been treated separately in experiments. Here we investigate whether they can be advantageously combined into one hybrid system, by exploring the immersion of a single trapped ion into a Bose-Einstein condensate of neutral atoms. We demonstrate independent control over the two components within the hybrid system, study the fundamental interaction processes and observe sympathetic cooling of the single ion by the condensate. Our experiment calls for further research into the possibility of using this technique for the continuous cooling of quantum computers. We also anticipate that it will lead to explorations of entanglement in hybrid quantum systems and to fundamental studies of the decoherence of a single, locally controlled impurity particle coupled to a quantum environment

Exploring Diet, Physical Activity, and Self-Reported Health Status Among Individuals in the Medically Underserved Population

The primary purpose of this study is to determine if certain lifestyle and health behaviors (e.g. smoking, physical activity, diet) in the medically underserved population have any influence on particular health statuses. This study also looked to determine if these health behaviors resulted in particular medical aliments being more prevalent or specific to this community. The secondary purpose of this study aims to gain information that may help health care providers practicing in this community to earlier identify risk factors in patients before a medical problem becomes more severe, difficult and expensive to treat. A survey, adapted from the CDC\u27s Behavioral Risk Factor Surveillance System (BRFSS), was created to allow for the collection of descriptive statistical data. The survey contains questions on the various topics of diet, physical activity, chronic diseases, and self-perception of overall health status. The survey was distributed to 20 older adult participants at Hebni Nutrition, LLC, all from disadvantaged backgrounds. Descriptive statistics were used to analyze the data. Of the 20 surveys collected, about half of the respondents reported consuming close to the recommended fruit and vegetable servings and participating in regular physical activity. Furthermore, the participants reported rates of diabetes and hypertension well above average. This study\u27s results were inconclusive as to whether any specific health behaviors among medically underserved individuals influence the prevalence of chronic diseases in this population; more likely a combination of many factors and overall poorer health habits that persist over a lifetime are contributors to chronic diseases among the medically underserved population