902 research outputs found
Antibiotic dose optimization for specific patient populations:With focus on patients with renal impairment
Antibiotic dose optimization for specific patient populations:With focus on patients with renal impairment
Brexit: The road ahead for EU-UK trade
The countdown to Brexit has started. Given the short timeframe to Brexit and the large trading volumes, the authors investigate which certainties and uncertainties exist regarding the future trade relationship between the European Union (EU) and the United Kingdom (UK). Certain is that the UK is leaving the EU on 29 March 2019. On the basis of the recently presented draft withdrawal agreement, however, the chances are apparent that the UK will not leave the EU Customs Union and the internal market during a transition period ending in December 2020. Taking into account a possible transition period, the authors discuss the most likely scenarios and their impact on trade between the EU and the UK, in particular from a customs perspective
A Sustainable Future for Frisian Folklore:Opportunities and Challenges for the sustainable Safeguarding to Intangible Cultural Heritage and Tourism in Friesland
A Sustainable Future for Frisian Folklore:Opportunities and Challenges for the sustainable Safeguarding to Intangible Cultural Heritage and Tourism in Friesland
Safety issues and harmful pharmacological interactions of nutritional supplements in Duchenne muscular dystrophy: considerations for Standard of Care and emerging virus outbreaks
At the moment, little treatment options are available for Duchenne muscular dystrophy (DMD). The absence of the dystrophin protein leads to a complex cascade of pathogenic events in myofibres, including chronic inflammation and oxidative stress as well as altered metabolism. The attention towards dietary supplements in DMD is rapidly increasing, with the aim to counteract pathology-related alteration in nutrient intake, the consequences of catabolic distress or to enhance the immunological response of patients as nowadays for the COVID-19 pandemic emergency. By definition, supplements do not exert therapeutic actions, although a great confusion may arise in daily life by the improper distinction between supplements and therapeutic compounds. For most supplements, little research has been done and little evidence is available concerning their effects in DMD as well as their preventing actions against infections. Often these are not prescribed by clinicians and patients/caregivers do not discuss the use with their clinical team. Then, little is known about the real extent of supplement use in DMD patients. It is mistakenly assumed that, since compounds are of natural origin, if a supplement is not effective, it will also do no harm. However, supplements can have serious side effects and also have harmful interactions, in terms of reducing efficacy or leading to toxicity, with other therapies. It is therefore pivotal to shed light on this unclear scenario for the sake of patients. This review discusses the supplements mostly used by DMD patients, focusing on their potential toxicity, due to a variety of mechanisms including pharmacodynamic or pharmacokinetic interactions and contaminations, as well as on reports of adverse events. This overview underlines the need for caution in uncontrolled use of dietary supplements in fragile populations such as DMD patients. A culture of appropriate use has to be implemented between clinicians and patients’ groups
Kritische vrienden onder de loep
Vanuit de visie dat (a) mogelijkheden voor een vraagstuk samen onderzocht moeten worden en dat (b) verkennen gepaard gaat met ondernemend gedrag, verwondering en verrassing, is deze uitgave geschreven. Deze verhaalt over Ă©Ă©n initiatief in het bijzonder: de labs Ontdekkingsstraten. Deze hebben plaatsgevonden in Assen en Hardenberg met ondernemers, overheden en studenten van de Hanzehogeschool Groningen en het Alfa-college Hardenberg. De labs Ontdekkingsstraten willen de retail in de binnenstad van Assen en Hardenberg versterken. De labs zijn gerelateerd aan het landelijke project Future-Proof Retail, een initiatief van 23 samenwerkende organisaties met steun van Stichting Detailhandelsfonds. Bij de labs wordt de methode kritischevriend gebruikt; deze is ontwikkeld door middel van design-based onderzoek door het lectoraat Ondernemen in Verandering van de Hanzehogeschool Groningen en het Alfa-college. De kritischevriendmethode bestaat uit een drietal fasen die samen met de proloog de structuur van deze uitgave vormen
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