Minimal 3-3-1 model, lepton mixing and muonium-antimuonium conversion

The recent experimental results on neutrino oscillation and on muonium-antimuonium conversion require extension of the minimal 3-3-1 model. We review the constraints imposed to the model by those measurements and suggest a pattern of leptonic mixing, with charged leptons in a non-diagonal basis, which accounts for the neutrino physics and circumvents the tight muonium-antimuonium bounds on the model. We also illustrate a scenario where this pattern could be realized.Comment: 4 pages; abbreviated version, conclusions unchange

Cannabinoid receptors in the inflammatory cells of canine atopic dermatitis

Background: Atopic dermatitis (AD) is one of the most common cutaneous inflammatory and pruritic diseases in dogs. Considering its multifactorial nature, AD can be a challenging disease to manage, and the therapeutic strategy must often be multimodal. In recent years, research has been moving toward the use of natural products which have beneficial effects on inflammation and itching, and no side effects. Cannabinoid receptors have been demonstrated to be expressed in healthy and diseased skin; therefore, one of the potential alternative therapeutic targets for investigating AD is the endocannabinoid system (ECS). Objective: To immunohistochemically investigate the expression of the cannabinoid receptor type 2 (CB2R), and the cannabinoid-related receptors G protein-coupled receptor 55 (GPR55), transient receptor potential vanilloid 1 (TRPV1) and ankyrin 1 (TRPA1) in mast cells (MCs), macrophages, dendritic cells (DCs), T cells, and neutrophils of the skin of dogs with AD. Animals: Samples of skin tissues were collected from eight dogs with AD (AD-dogs). Materials and methods: The immunofluorescent stained cryosections of the skins of 8 dogs with AD having antibodies against CB2R, GPR55, TRPV1, TRPA1 were semiquantitatively evaluated. The inflammatory cells were identified using antibodies against tryptase (mast cells), ionized calcium binding adaptor molecule 1 (IBA1) (macrophages/DCs), CD3 (T cells), and calprotectin (neutrophils). The proportions of MCs, macrophages/DCs, T cells, and neutrophils expressing CB2R, GPR55, TRPV1 and TRPA1 were evaluated. Results: The cells of the inflammatory infiltrate showed immunoreactivity (IR) for all or for some of the cannabinoid and cannabinoid-related receptors studied. In particular, MCs and macrophages/DCs showed CB2R-, GPR55-, TRPA1-, and TRPV1-IR; T cells showed CB2R-, GPR55- and TRPA1-IR, and neutrophils expressed GPR55-IR. Co-localization studies indicated that CB2R-IR was co-expressed with TRPV1-, TRPA1-, and GPR55-IR in different cellular elements of the dermis of the AD-dogs. Conclusions and clinical importance: Cannabinoid receptor 2, and cannabinoid-related receptors GPR55, TRPV1 and TRPA1 were widely expressed in the inflammatory infiltrate of the AD-dogs. Based on the present findings, the ECS could be considered to be a potential therapeutic target for dogs with AD, and may mitigate itch and inflammation

Distribution of Cannabinoid Receptors in Keratinocytes of Healthy Dogs and Dogs With Atopic Dermatitis

It is commonly accepted that some form of skin barrier dysfunction is present in canine atopic dermatitis (AD), one of the most common cutaneous pruritic inflammatory diseases of dogs. The impaired skin barrier function facilitates the penetration of allergens and subsequently stronger sensitization responses. The role of the endocannabinoid system (ECS) in the physiology and pathology of the skin is becoming increasingly established. It has been demonstrated that cannabinoid receptors are expressed in healthy and diseased skin and, based on current knowledge, it could be stated that cannabinoids are important mediators in the skin. The present study has been designed to immunohistochemically investigate the expression of the cannabinoid receptors type 1 (CB1R) and 2 (CB2R) and the cannabinoid-related receptors G protein-coupled receptor 55 (GPR55), transient receptor potential vanilloid 1 (TRPV1) and ankyrin 1 (TRPA1), peroxisome proliferator-activated receptors alpha (PPARα), and serotoninergic receptor 1a (5-HT1aR) in keratinocytes of healthy dogs and of dogs with AD. Samples of skin tissues were collected from 7 healthy controls (CTRL-dogs) and from 8 dogs with AD (AD-dogs). The tissue samples were processed using an immunofluorescence assay with commercially available antibodies, and the immunolabelling of the receptors studied was quantitatively evaluated. The keratinocytes of the CTRL- and the AD-dogs showed immunoreactivity for all the receptors investigated with a significant upregulation of CB2R, TRPA1, and 5-HT1aR in the epidermis of the AD-dogs. The presence of cannabinoid and cannabinoid-related receptors in healthy keratinocytes suggested the possible role of the ECS in canine epidermal homeostasis while their overexpression in the inflamed tissues of the AD-dogs suggested the involvement of the ECS in the pathogenesis of this disease, having a possible role in the related skin inflammation and itching. Based on the present findings, the ECS could be considered a potential therapeutic target for dogs with AD

Avaliação de progênies F5 de melancia de frutos pequenos e polpa amarela.

O presente trabalho objetivou avaliar o desempenho agronômico de 19 progênies F5 de melancia. O ensaio foi realizado na Estação Experimental da Embrapa Rondônia, localizado em Porto-Velho - RO. Empregou-se o delineamento de blocos casualizados, três repetições e parcelas de seis plantas. Avaliaram-se: precocidade, prolificidade, peso e tamanho de fruto, teor de sólidos solúveis na polpa e espessura de casca. Houve predominância dos frutos de casca verde clara (86,4%), rendilhados (64,8%) e de polpa amarela e laranja (92,2%). A maioria das progênies foi precoce e produziu frutos pequenos, arredondados e de casca fina. O excesso de chuvas no final do ciclo prejudicou o desenvolvimento e a qualidade dos frutos, que apresentaram peso médio (2,7 a 3,9 kg) e teor médio de sólids solúveis (5,7 a 9,3 oBrix) bastante reduzidos.Suplemento. Edição dos Resumos Expandidos do 45. Congresso Brasileiro de Olericultura; 15. Congresso Brasileiro de Floricultura e Plantas Ornamentais; 2. Congresso Brasileiro de Cultura de Tecidos de Plantas, Fortaleza, ago. 2005

Correlações entre caracteres morfo-agronômicos de melancia.

Este trabalho teve como objetivo estimar correlações entre os principais caracteres morfo-agronômicos úteis ao melhoramento genético da melancia.Suplemento. Edição dos resumos expandidos do 45. Congresso Brasileiro de Olericultura; 15. Congresso Brasileiro de Floricultura e Planta Ornamentais; 2. Congresso Brasileiro de Cultura de Tecidos de Plantas, Fortaleza, ago. 2005. 1 CD-ROM

Developing a nationally appropriate mitigation measure from the greenhouse gas abatement potential from livestock production in the Brazilian Cerrado.

Brazil is one of the first major developing countries to commit to a national greenhouse gas (GHG) emissions target that requires a reduction of between 36.1% and 38.9% relative to baseline emissions by 2020. The country intends to submit to agricultural emissions reductions as part of this target with livestock production identified as offering significant abatement potentia

Polinização artificial em progênies F6 de melancia conduzidas em campo.

Este trabalho objetivou avaliar a eficiência da polinização artificial em plantas de melancia conduzidas em campo.Suplemento. Edição dos resumos expandidos do 45. Congresso Brasileiro de Olericultura; 15. Congresso Brasileiro de Floricultura e Plantas Ornamentais; 2. Congresso Brasileiro de Cultura de Tecidos de Plantas, Fortaleza, ago. 2005. 1 CD-ROM

OntoEPFS: uma ontologia para experimentos em mapeamento digital de solos.

A descrição formal de experimentos para aquisição, tratamento, análises de dados, compartilhamento e reprodução dos resultados obtidos é fundamental para os cientistas envolvidos. Ontologias vêm sendo utilizadas para criar modelos formais para disseminação de informação e conhecimento. Este artigo apresenta uma ontologia para apoiar o Experimento de Predição de Informações de Fertilidades de Solos (OntoEPFS) em Mapeamento Digital de Solos (DSM). O EPFS se encontra em desenvolvimento na Empresa Brasileira de Pesquisa Agropecuária, no Centro Nacional de Pesquisa em Solos ? Embrapa Solos. A adoção dessa ontologia, por parte da Embrapa Solos, facilitará a descrição, a formalização e a disponibilização de conhecimentos sobre os experimentos realizados por esta unidade.SBIAgro 2009

Escolha de genitores em melancia, por meio de técnicas de análise multivariada.

Este trabalho objetivou determinar a divergência genética entre os genótipos Crimson Sweet, Charleston Gray, Fair Fax, Sugar Baby, Omaro Yamato, Congo e cinco progênies F5 do programa de melhoramento genético de melancia da Embrapa Rondônia.Suplemento. Edição dos resumos expandidos do 45. Congresso Brasileiro de Olericultura; 15. Congresso Brasileiro de Floricultura e Plantas Ornamentais; 2. Congresso Brasileiro de Cultura de Tecidos de Plantas, Fortaleza, ago. 2005