Track E Implementation Science, Health Systems and Economics

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138412/1/jia218443.pd

Blepharospasm, dry eye and extractable nuclear antigen antibodies

International audiencePurposeTo study whether there is an association between benign essential blepharospasm and Sjögren's syndrome by analyzing the presence of antibodies to extractable nuclear antigens in this population.MethodsSeventy-two patients with benign essential blepharospasm (BEB) were included in this study. We excluded patients with hemifacial spasm or blepharospasm secondary to known corneal pathology. We recorded results of Schirmer I testing as well as levels of anti-SSA/Ro and anti-SSB/La antibodies.ResultsOur study included 72 patients (144 eyes), of which 62 (86.1%) were women. The mean age was 74.3 ± 10.73 years. The mean Schirmer I test result was 3.14 ± 4.00 mm. Five women (8% of this female population) were found to have positive anti-SSA/Ro and anti-SSB/La antibodies. Their mean age was 65.66 ± 13.24 years, while the mean age of the antibody-negative patients was 75.42 ± 9.27 years. There was no statistically significant difference between the Schirmer I tests of the antibody positive and negative patients.ConclusionThis study demonstrates a possible association between Sjögren's syndrome and benign essential blepharospasm, justifying anti-SSA/Ro and anti-SSB/La testing in these patients

Blépharospasme, sécheresse oculaire et anticorps anti-nucléaires solubles

International audiencePurposeThe goal of this study is to determine a link between benign essential blepharospasm and Sjogren's syndrome by analyzing the presence of extractable nuclear antigens in this population.MethodsSeventy-two patients with benign essential blepharospasm (BEB) were included in this study. We eliminated patients with hemifacial spasm or blepharospasm secondary to corneal pathology. We collected the values of the Schirmer I test and the results of the anti-SSA and anti-SSB antibodies.ResultsOur study included 72 patients (144 eyes) whose 62 women (86.1%). Mean age was 74.3 years ± 10.73. Average Schirmer I test was 3.14 mm ± 4.00 mm. Five women (8% of this female population) had positive anti-SSA and SSB antibodies. Their mean age was 65.66 years ± 13.24 whereas the negative antibody patients had an average age of 75.42 ± 9.27. There was no significant difference between their Schimer I test and the Schirmer I of negative antibody population.ConclusionThis study illustrates the possible association between the presence of Sjögren's syndrome and the occurrence of a BEB justifying the search for anti-SSA and anti SSB in blepharospasm patients.ObjectifÉtudier s’il existe un lien entre le blépharospasme essentiel et le syndrome de Sjögren en analysant la présence d’anticorps nucléaires solubles dans cette population.MéthodesSoixante douze patients atteints de blépharospasme essentiel (BSE) ont été inclus dans cette étude. Nous avons éliminé les patients atteints de spasme hémifacial, ou de blépharospasme secondaire à une pathologie cornéenne avérée. Nous avons recueilli les valeurs des test de Schirmer I et les résultats des anticorps anti-SSA et anti-SSB.RésultatsNotre étude a regroupé 72 patients (144 yeux) dont 62 femmes (86,1 %). L’âge moyen était de 74,3 ans ± 10,73. Le test de Schirmer I était en moyenne de 3,14 mm ± 4,00 mm. Cinq femmes (8 % de cette population féminine) ont révélés des anticorps anti-SSA et SSB positifs. Leur moyenne d’âge était de 65,66 ans ± 13,24 alors que les patients anticorps négatifs avaient une moyenne d’âge de 75,42 ± 9,27. Il n’existait pas de différence statistiquement significative entre leur test de Schimer I et celui des patients anticorps négatifs.ConclusionCette étude illustre la possible association entre la présence d’une maladie de Sjögren et la présence d’un BSE justifiant la recherche d’anticorps anti-SSA et SSB chez ces patients