3 research outputs found
Automated 3D geometry segmentation of the healthy and diseased carotid artery in free-hand, probe tracked ultrasound images
Purpose: Rupture of an arterosclerotic plaque in the carotid artery is a major cause of stroke. Biomechanical analysis of plaques is under development aiming to aid the clinician in the assessment of plaque vulnerability. Patient-specific three-dimensional (3D) geometry assessment of the carotid artery, including the bifurcation, is required as input for these biomechanical models. This requires a high-resolution, 3D, noninvasive imaging modality such as ultrasound (US). In this study, a high-resolution two-dimensional (2D) linear array in combination with a magnetic probe tracking device and automatic segmentation method was used to assess the geometry of the carotid artery. The advantages of using this system over a 3D ultrasound probe are its higher resolution (spatial and temporal) and its larger field of view. Methods: A slow sweep (v = ± 5 mm/s) was made over the subject’s neck so that the full geometry of the bifurcated geometry of the carotid artery is captured. An automated segmentation pipeline was developed. First, the Star-Kalman method was used to approximate the center and size of the vessels for every frame. Images were filtered with a Gaussian high-pass filter before conversion into the 2D monogenic signals, and multiscale asymmetry features were extracted from these data, enhancing low lateral wall-lumen contrast. These images, in combination with the initial ellipse contours, were used for an active deformable contour model to segment the vessel lumen. To segment the lumen–plaque boundary, Otsu’s automatic thresholding method was used. Distension of the wall due to the change in blood pressure was removed using a filter approach. Finally, the contours were converted into a 3D hexahedral mesh for a patient-specific solid mechanics model of the complete arterial wall. Results: The method was tested on 19 healthy volunteers and on 3 patients. The results were compared to manual segmentation performed by three experienced observers. Results showed an average Hausdorff distance of 0.86 mm and an average similarity index of 0.91 for the common carotid artery (CCA) and 0.88 for the internal and external carotid artery. For the total algorithm, the success rate was 89%, in 4 out of 38 datasets the ICA and ECA were not sufficient visible in the US images. Accurate 3D hexahedral meshes were successfully generated from the segmented images. Conclusions: With this method, a subject-specific biomechanical model can be constructed directly from a hand-held 2D US measurement, within 10 min, with a minimal user input. The performance of the proposed segmentation algorithm is comparable to or better than algorithms previously described in literature. Moreover, the algorithm is able to segment the CCA, ICA, and ECA including the carotid bifurcation in transverse B-mode images in both healthy and diseased arteries
A generalized approach for automatic 3-D geometry assessment of blood vessels in transverse ultrasound images using convolutional neural networks
Accurate 3-D geometries of arteries and veins are important clinical data for diagnosis of arterial disease and intervention planning. Automatic segmentation of vessels in the transverse view suffers from the low lateral resolution and contrast. Convolutional neural networks are a promising tool for automatic segmentation of medical images, outperforming the traditional segmentation methods with high robustness. In this study, we aim to create a general, robust, and accurate method to segment the lumen-wall boundary of healthy central and peripheral vessels in large field-of-view freehand ultrasound (US) datasets. Data were acquired using freehand US, in combination with a probe tracker. A total of ± 36000 cross-sectional images, acquired in the common, internal, and external carotid artery (N = 37), in the radial, ulnar artery, and cephalic vein (N = 12), and in the femoral artery (N = 5) were included. To create masks (of the lumen) for training data, a conventional automatic segmentation method was used. The neural networks were trained on a) data of all vessels and b) the carotid artery only. The performance was compared and tested using an open access dataset. The Recall, Precision, DICE, and the intersect-over-union (IoU) were calculated. Overall, segmentation was successful in the carotid and peripheral arteries. The Multires U-net architecture performs best overall with DICE = 0.93 when trained on the total dataset. Future studies will focus on the inclusion of vascular pathologies
Unsupervised domain adaptation method for segmenting cross-sectional CCA images
BACKGROUND AND OBJECTIVES: Automatic vessel segmentation in ultrasound is challenging due to the quality of the ultrasound images, which is affected by attenuation, high level of speckle noise and acoustic shadowing. Recently, deep convolutional neural networks are increasing in popularity due to their great performance on image segmentation problems, including vessel segmentation. Traditionally, large labeled datasets are required to train a network that achieves high performance, and is able to generalize well to different orientations, transducers and ultrasound scanners. However, these large datasets are rare, given that it is challenging and time-consuming to acquire and manually annotate in-vivo data. METHODS: In this work, we present a model-based, unsupervised domain adaptation method that consists of two stages. In the first stage, the network is trained on simulated ultrasound images, which have an accurate ground truth. In the second stage, the network continues training on in-vivo data in an unsupervised way, therefore not requiring the data to be labelled. Rather than using an adversarial neural network, prior knowledge on the elliptical shape of the segmentation mask is used to detect unexpected outputs. RESULTS: The segmentation performance was quantified using manually segmented images as ground truth. Due to the proposed domain adaptation method, the median Dice similarity coefficient increased from 0 to 0.951, outperforming a domain adversarial neural network (median Dice 0.922) and a state-of-the-art Star-Kalman algorithm that was specifically designed for this dataset (median Dice 0.942). CONCLUSIONS: The results show that it is feasible to first train a neural network on simulated data, and then apply model-based domain adaptation to further improve segmentation performance by training on unlabeled in-vivo data. This overcomes the limitation of conventional deep learning approaches to require large amounts of manually labeled in-vivo data. Since the proposed domain adaptation method only requires prior knowledge on the shape of the segmentation mask, performance can be explored in various domains and applications in future research