Price Decision Making in a Centralized/Decentralized Solid Waste Disposal Supply Chain with One Contractor and Two Disposal Facilities

Part 1: Smart Supply NetworksInternational audienceSolid waste management has been an interesting topic for researchers in few last decades. This paper studies a price-sensitive demand for the waste disposal service of two disposal facilities who are dealing with a contractor to gain more profit. The waste disposal process is studied in a supply chain structure where a contractor manages to collect the waste from the producers and transport them to the facilities for disposal. Two scenarios are proposed where at the first one the disposal facilities lead a price Stackelberg game over the contractor, and in the second scenario, both disposal facilities and the contractor cooperate on the chain decision variables in an integrated framework. A numerical example is performed to illustrate the efficiency and applications of the proposed model

Identification in silico of putative damage responsive elements (DRE) in promoter regions of the yeast genome

We report an in silico analysis to identify nucleotide sequence motifs in DNA repair genes that may define a binding site for regulatory proteins during the induction of those genes by mutagens. The damage responsive elements (DRE) weight matrix generated in this analysis was used to search for homologous sequences in the promoter region of all genes, including putative gene and hypothetical open reading frames (ORFs), in the Saccharomyces Genome Data Base (SGD). The results demonstrated that over one third of the yeast genes in the database presented at least one 15-bp sequence in their promoter region with 85% or more of similarity to the DRE consensus sequence. The presence of the DRE sequence in the promoter region of regulatory genes and its high similarity to other well reported DNA binding sites points to its involvement in the general regulation of not only DNA repair genes but yeast genes in general