Mycosis Fungoides and Sézary Syndrome: Microenvironment and Cancer Progression

Mycosis fungoides and Sézary syndrome are epidermotropic cutaneous lymphomas, and both of them are rare diseases. Mycosis fungoides is the most frequent primary cutaneous lymphoma. In about 25% of patients with mycosis fungoides, the disease may progress to higher stages. The pathogenesis and risk factors of progression in mycosis fungoides and Sézary syndrome are not yet fully understood. Previous works have investigated inter- and intrapatient tumor cell heterogeneity. Here, we overview the role of the tumor microenvironment of mycosis fungoides and Sézary syndrome by describing its key components and functions. Emphasis is put on the role of the microenvironment in promoting tumor growth or antitumor immune response, as well as possible therapeutic targets. We focus on recent advances in the field and point out treatment-related alterations of the microenvironment. Deciphering the tumor microenvironment may help to develop strategies that lead to long-term disease control and cure

Immunopathologie du psoriasis

Le psoriasis est une maladie inflammatoire fréquente atteignant essentiellement la peau et parfois les articulations. Cette maladie chronique met rarement en jeu le pronostic vital mais altère significativement la qualité de vie. Le psoriasis est caractérisé, dans sa forme la plus fréquente, par des plaques érythémato-squameuses bien limitées associées à une prolifération exagérée des kératinocytes de l’épiderme, une inflammation et une hypervascularisation du derme superficiel. L’implication des lymphocytes T CD4 de type Th1 a été suspectée initialement. Plus récemment, la découverte du rôle prépondérant des lymphocytes T CD4 de type Th17 dans la maladie a conduit au développement d’inhibiteurs spécifiques de cette voie, tels que les anticorps anti-IL(interleukine)-23 (cytokine favorisant la différenciation des lymphocytes en Th17), anti-IL-17, anti-IL-17RA (récepteur de l’IL-17) et IL-22 (cytokine produite notamment par les lymphocytes Th17)

Involvement of the CD39/CD73/adenosine pathway in T-cell proliferation and NK cell-mediated antibody-dependent cell cytotoxicity in Sézary syndrome

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Acropulpitis in systemic lupus erythematosus is associated with high type 1 interferon signature

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Large‐cell transformation is an independent poor prognostic factor in Sézary syndrome: analysis of 117 cases

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CCR8 is a new therapeutic target in cutaneous T-cell lymphomas

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Increased CD8CD28 circulating T cells and high blood interferon score characterize the systemic inflammation of amyopathic dermatomyositis.

Amyopathic dermatomyositis (ADM) is a subtype of DM defined by the presence of cutaneous signs of DM with no evidence of muscle weakness or abnormal muscle enzymes for ≥ 6 months.1 Classical DM (CDM) is characterized by modification of circulating lymphocytes 4, type I interferon (IFN) signature 2, elevation of serum pro-inflammatory cytokines 3. Pathophysiology of ADM is less studied. We analysed circulating T cells by flowcytometry (using specific monoclonal antibodies), peripheral blood mononuclear cells type I IFN signature by PCR and serum cytokine levels by ELISA in a series of 17 ADM and 15 CDM patients. [...

Increased CD8+CD28- circulating T cells and high blood interferon score characterize the systemic inflammation of amyopathic dermatomyositis

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Increased CD8+CD28- circulating T cells and high blood interferon score characterize the systemic inflammation of amyopathic dermatomyositis

International audienceNo abstract availabl