An easier measurement of the parameters evolution analysis of lower limb wound: The non invasive 3-D scanning

This work consists of carrying out an objective quantification of dimensions and volume loss of skin substance using an optical 3D reading system. This technique, simple, non-invasive and reproducible, can be integrated into epidemiological studies of ulcerations of the lower limbs and to measure their evolution. This technique also makes it possible to be integrated into therapeutic efficacy studies dressing wounds and being able to rigorously and critically objectify the effectiveness of these treatments

A Belgian consensus on the definition of a treat‐to‐target outcome set in psoriasis management

Objective: Treat-to-target (T2T) is an algorithm to reach a predefined outcome. Here, we define a T2T outcome for moderate-to-severe psoriasis vulgaris. Methods: Briefly, the study included a literature review, discussions with key opinion leaders, recruitment of additional dermatologists with experience in managing moderate-to-severe psoriasis, 3 eDelphi survey rounds and a patient focus group. Relevant topics were selected during discussions prior to the survey for the statements. Surveys were based on the eDelphi methodology for consensus-building using a series of statements. Consensus was defined as at least 80% of participants agreeing. A psoriasis patient focus group provided feedback on topic selection and outcome. Results: A total of 5 discussions were held, and 3 eDelphi rounds were conducted with an average of 19 participants per round. The T2T outcome was set assuming shared decision between patient and dermatologist, awareness and referral for comorbidities by the dermatologist and appropriate treatment adherence by the patient. We defined 'ideal' and 'acceptable' targets; the latter referring to conditions restricting certain drugs. The T2T outcome was multidimensional, including >= Delta PASI90/75 or PGA <= 1, itch VAS score <= 1, absence of disturbing lesions, DLQI <= 1/3, incapacity daily functioning VAS score <= 1, safety <= mild side-effects and full/mild tolerability of treatment for the ideal and acceptable target, respectively. Finally, time to achieve the T2T outcome was set at 12 weeks after initiation for all treatments. At all times, safety should not exceed the presence of mild side-effects. Conclusion: With this novel T2T composite outcome for psoriasis, clinicians and patients can make shared decisions on the treatment goals they envisage, as a guidance for future treatment steps - leading to a tight control management of the disease

Psoriasis and Psoriatic Arthritis

peer reviewedPsoriasis is a frequent multifactorial chronic skin disease that can lead to a decreased quality of life. Some patients also present arthritis. Those two complex inflammatory diseases share some of their characteristics, but several clinical manifestations can be distinguished in each of them. In addition to classical medications (constituted of topical treatments, methotrexate, ciclosporin and retinoids for cutaneous psoriasis and non steroidal anti-inflammatory drugs or methotrexate for psoriatic arthritis), they are the target of a new generation of therapies: the biologics

Subungual chronic radiodermatitis.

We report a patient who developed a subungual radiodermatitis 25 years following radiotherapy for a verruca of the lateral nail fold. The different stages and the treatment of chronic radiodermatitis of the nail apparatus are described. We want to emphasize the late onset of such lesions and the prime importance of the anamnesis.Case ReportsJournal Articleinfo:eu-repo/semantics/publishe

Biological therapy of inflammatory diseases

peer reviewedThe pathophysiology and the treatment of diseases with clinical presentation so different as rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis and psoriasis vulgaris have been revolutionized by the discovery of common pro-inflammatory effector mechanisms involving TNF-alpha and by the use of targeted therapies, the anti-TNF-alpha antibodies. In the past 10 years, our experience has helped several hundreds of patients who were treated with novel drugs, years before they became routinely available. In parallel tools of metrology were developped that can now be applied to the routine patient. Lastly, clinical research on these new drugs has also generated derived research works allowing the university hospital to satisfactorilly fullfil its specific missions

Comparison of IgE-dependant sensitization rate to moulds, dermatophytes and yeasts in patients with typical allergic diseases compared to those with inflammatory dermatitis

We aimed to determine IgE-dependant skin sensitization rates to moulds, dermatophytes and yeasts in patients with typical allergic diseases in comparison to those with inflammatory dermatitis seen over the course of one year. Skin prick tests were done in 267 patients (172 women and 95 men; median age 38 years, range 25–50 years). We allocated them into 8 groups: 64 with head and neck atopic dermatitis; 11 with seborrheic dermatitis; 52 with eczema and not atopic dermatitis other than on the head and neck; 64 with rhinitis, conjunctivitis and asthma; 28 with urticaria; 10 with food allergy; and 12 healthy controls. Skin tests were done with the following aqueous standardized commercial extracts: Alternaria, Penicillium, Aspergillus, Cladosporium, Mucor, Trichophyton, Epidermophyton, Candida albicans, Malassezia and Saccharomyces cerevisiæ. Globally, positive skin test reactions occurred most frequently with the yeast extracts, less to the dermatophytes and even less to the moulds. The results were homogenous among members of each group. The relevance of our tests was reinforced by the fact that the moulds that gave positive skin tests most frequently were those most often isolated in the Belgian environment. In patients with atopic dermatitis of the head and neck, positive tests were most frequent with four moulds and three yeasts; compared to this group, positive tests were less frequent in patients with atopic dermatitis localized to other sites. In inflammatory dermatitis of the head and neck, the study of immediate hypersensitivity to yeasts seems to be important.Objectifs. – Nous avons tenté de déterminer les taux de sensibilisation IgE-dépendante aux moisissures, aux dermatophytes et aux levures dans les maladies allergiques générales en comparaison avec les dermatoses inflammatoires chez tous nos patients durant une année. Matériel et méthodes. – Nous avons réalisé des « prick tests » chez 267 patients, 172 femmes (64 %) et 95 hommes (36 %), d’âge médian 38 ans (25–50). Nous les avons répartis en huit groupes : dermatite atopique de la tête et du cou (64) ; dermatite séborrhéique (26) ; sébopsoriasis (11) ; eczéma du corps (52) ; rhinite, conjonctivite et asthme (64) ; urticaire (28) ; allergie alimentaire (10) ; témoins (12). Des extraits aqueux, standardisés et commercialisés de : Alternaria, Penicillium, Aspergillus, Cladosporium, Mucor, Trichophyton, Epidermophyton, Candida albicans, Malassezia, Saccharomyces cerevisiæ ont été utilisés en « prick tests ». Résultats et conclusions. – Globalement, les groupes de champignons se positionnaient par ordre de fréquence de positivité comme suit : les levures, les dermatophytes et enfin les moisissures. La pertinence de nos tests était renforcée par le fait que les moisissures les plus fréquemment positives en « prick tests » sont le plus souvent isolées dans l’environnement belge. Les résultats dans chacun des trois groupes étaient homogènes entre eux. Dans la dermatite atopique de la tête et du cou existait le nombre le plus élevé de « prick tests » positifs aux quatre moisissures et aux trois levures. Dans ce groupe, les taux de positivité étaient plus élevés même en comparaison avec l’eczéma d’une autre localisation. Dans les dermatoses inflammatoires de la région céphalique, l’étude des levures paraissait importante

Les manifestations cutanées liées à l'insuffisance veineuse chronique IVC

Toutes les altérations consécutives à la dilatation des veines des membres inférieurs, à l'incompétence de leurs valvules et à l'augmentation de pression veineuse constituent l'insuffisance veineuse chronique (IVC). Après avoir brièvement rappelé les mécanismes physiopathologiques à la base de l'IVC, nous évoquons dans cet article les manifestations cutanées associées à cette dernières ainsi que les traitements possibles, lorsqu'ils existent

Un cas d’urticaire cholinergique

info:eu-repo/semantics/publishe