Reported adverse drug reactions during the use of inhaled steroids in children with asthma in the Netherlands

Objective: Inhaled corticosteroids (ICS) are widely used in the treatment of asthma. We studied the suspected adverse drug reactions (sADRs) reported during the use of ICS in the Netherlands. Methods: In the Netherlands, health professionals and patients can report suspected ADRs to the Pharmacovigilance Centre Lareb. All reported sADRs on ICS were categorised and assessed as to whether these were likely to be associated with use of the steroid. Age and gender adjusted Reported Odds Ratios (RORs) and Naranjo Scores (NS) were computed for sADRs reported more than 3 times. Results: Since 1984, sADRs of ICS were reported in 89 children (mean age 6 years), 48 (54%) were boys. Suspected drugs were fluticasone in 46 children (52%), budesonide in 21 (24%), and beclomethasone in 22 cases (24%). Psychiatric symptoms were reported in 19 children (21%; ROR 3.8, NS 3.6), growth retardation in 6 children (7%; ROR 47.8, NS 3.0) and rashes in 6 cases (7%; ROR 0.7, NS 2.4). There were 7 reports (8%; ROR 2.1, NS 3.4) concerning abnormalities of the teeth, 4 reports of alopecia (4%; ROR 3.3, NS 3.5), and 3 reports of hirsutism and hypertrichosis (NS 4.0). Non-fatal adrenal insufficiency was reported once. Conclusion: Alteration of behaviour was the most frequently reported sADR. There are more indications that alterations of behaviour could be a real sADR of ICS. Non-fatal adrenal insufficiency was the only reported possible life threatening sADR. The association of hypertrichosis and teeth abnormalities after ICS in children has not been reported in the literature before

Helping teammates during product selling: when does it pay off?

Abstract in articl

Helping teammates during product selling: when does it pay off?

Abstract in articl

Verbindingsmaatlat voor de landbouw : ontwikkeling van een indicator die een beeld geeft van de verbinding tussen een biologisch landbouwbedrijf en zijn omgeving : onderdeel van koepelproject Duurzaamheidprestaties Biologische Landbouw

Eén van de kenmerken van duurzaamheid, in de traditionele people, plant, profit indeling, is de mate waarin landbouw zich weet te verbinden aan de maatschappij. Deze studie focust zich op de ontwikkeling van een indicator die de mate van verbinding weergeeft. Omdat verbinding het resultaat is van een complexe sociale interactie die lastig meetbaar is, is er geen indicator beschikbaar die direct iets zegt over de mate van verbinding die een bedrijf of een sector weet te realiseren. Omdat er weinig informatie wordt vastgelegd over verbindingen die ondernemers aangaan in bestaande databases is ervoor gekozen om een indicator te ontwikkelen die direct door de ondernemer ingevuld kan worden. In deze studie is een eerste aanzet gedaan voor de ontwikkeling van deze duurzaamheidsindicator voor verbindingen