52 research outputs found
The Role of Corporate Reputation Versus Relationships in Building Employer Brand Equity: The case of a Major Private Hospital
In Australia and many other developed countries, there are now acute skills shortages in a number of different industries - healthcare being a notable example. The need to attract and retain the best available employees has become a critical managerial task. Building a strong employer brand offers a promising approach to this problem. The academic literature is still at a relatively early stage of development but internal relationship marketing and corporate reputation have been identified as two key concepts associated with employer branding. This case study of a private hospital in Australia explores the role of these concepts in building employer brand equity. Initial findings suggest corporate reputation has an asymmetric impact - the costs of a negative reputation far outweigh the benefits of a positive one
Reputation or relationships: What really drives perceptions of employer attractiveness in the health industry?
Managing relationships with key stakeholders has long been regarded as a central concern of corporate public relations. In recent years, however, the concept of reputation management has gained rapidly in popularity, potentially supplanting relationships as the discipline's driving philosophy. This paper presents a case study of a major private hospital in Australia, focusing on the respective roles of corporate reputation versus relationships in forming perceptions of employer attractiveness. Through depth interviews and focus groups involving hospital management and highly skilled professionals, this study investigates what drives perceptions of employer attractiveness. Ramifications for the theory and practice of public relations are discussed
The c.429_452 duplication of the ARX gene: a unique developmental-model of limb kinetic apraxia:
BACKGROUND: The c.429_452dup24 of the ARX gene is a rare genetic anomaly, leading to X-Linked Intellectual Disability without brain malformation. While in certain cases c.429_452dup24 has been associated with specific clinical patterns such as Partington syndrome, the consequence of this mutation has been also often classified as "non-specific Intellectual Disability". The present work aims at a more precise description of the clinical features linked to the c.429_452dup24 mutation. METHODS: We clinically reviewed all affected patients identified in France over a five-year period, i.e. 27 patients from 12 different families. Detailed cognitive, behavioural, and motor evaluation, as well as standardized videotaped assessments of oro-lingual and gestural praxis, were performed. In a sub-group of 13 ARX patients, kinematic and MRI studies were further accomplished to better characterize the motor impairment prevalent in the ARX patients group. To ensure that data were specific to the ARX gene mutation and did not result from low-cognitive functioning per se, a group of 27 age- and IQ-matched Down syndrome patients served as control. RESULTS: Neuropsychological and motor assessment indicated that the c.429_452dup24 mutation constitutes a recognizable clinical syndrome: ARX patients exhibiting Intellectual Disability, without primary motor impairment, but with a very specific upper limb distal motor apraxia associated with a pathognomonic hand-grip. Patients affected with the so-called Partington syndrome, which involves major hand dystonia and orolingual apraxia, exhibit the most severe symptoms of the disorder. The particular "reach and grip" impairment which was observed in all ARX patients, but not in Down syndrome patients, was further characterized by the kinematic data: (i) loss of preference for the index finger when gripping an object, (ii) major impairment of fourth finger deftness, and (iii) a lack of pronation movements. This lack of distal movement coordination exhibited by ARX patients is associated with the loss of independent digital dexterity and is similar to the distortion of individual finger movements and posture observed in Limb Kinetic Apraxia. CONCLUSION: These findings suggest that the ARX c.429_452dup24 mutation may be a developmental model for Limb Kinetic Apraxia
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Cerebellar and subcortical atrophy contribute to psychiatric symptoms in frontotemporal dementia
Data Availability Statement: The data that support the findings of this study are available on request via https://www.genfi.org/study/ or by emailing [email protected]. The data are not publicly available due to privacy or ethical restrictions.Supporting Information: available online at: https://onlinelibrary.wiley.com/doi/10.1002/hbm.26220#support-information-section .Copyright © 2023 The Authors. Recent studies have reported early cerebellar and subcortical impact in the disease progression of genetic frontotemporal dementia (FTD) due to microtubule-associated protein tau (MAPT), progranulin (GRN) and chromosome 9 open reading frame 72 (C9orf72). However, the cerebello-subcortical circuitry in FTD has been understudied despite its essential role in cognition and behaviors related to FTD symptomatology. The present study aims to investigate the association between cerebellar and subcortical atrophy, and neuropsychiatric symptoms across genetic mutations. Our study included 983 participants from the Genetic Frontotemporal dementia Initiative including mutation carriers and noncarrier first-degree relatives of known symptomatic carriers. Voxel-wise analysis of the thalamus, striatum, globus pallidus, amygdala, and the cerebellum was performed, and partial least squares analyses (PLS) were used to link morphometry and behavior. In presymptomatic C9orf72 expansion carriers, thalamic atrophy was found compared to noncarriers, suggesting the importance of this structure in FTD prodromes. PLS analyses demonstrated that the cerebello-subcortical circuitry is related to neuropsychiatric symptoms, with significant overlap in brain/behavior patterns, but also specificity for each genetic mutation group. The largest differences were in the cerebellar atrophy (larger extent in C9orf72 expansion group) and more prominent amygdalar volume reduction in the MAPT group. Brain scores in the C9orf72 expansion carriers and MAPT carriers demonstrated covariation patterns concordant with atrophy patterns detectable up to 20 years before expected symptom onset. Overall, these results demonstrated the important role of the subcortical structures in genetic FTD symptom expression, particularly the cerebellum in C9orf72 and the amygdala in MAPT carriers.Alzheimer Society of Canada; Weston Brain Institute; Fonds de Recherche du Québec - Santé; MRC UK GENFI, Grant/Award Number: MR/M023664/1; Italian Ministry of Health, Grant/Award Number: CoEN015; Canadian Institutes of Health Research; Alzheimer's Society grant, Grant/Award Number: AS-PG-16-007; Alzheimer's Society, Grant/Award Number: AS-JF-19a-004-517; NIHR Rare Diseases Translational Research Collaboration; Deutsche Forschungsgemeinschaft; NIHR Cambridge Biomedical Research Centre, Grant/Award Numbers: BRC-1215-20014, BRC149/NS/MH
Timing of Palaeozoic magmatism in the Maggia and Sambuco nappes and paleogeographic implications (Central Lepontine Alps)
Magmatic rocks from the pre-Mesozoic basements of the Sambuco and Maggia
nappes have been dated by U-Pb zircon ages with the LA-ICPMS technique.
Several magmatic events have been identified in the Sambuco nappe. The
mafic banded calc-alkaline suite of Scheggia is dated at 540 Ma, an age
comparable to that of mafic rocks in the Austroalpine Silvretta nappe.
The Sasso Nero peraluminous augengneiss has an age of 480-470 Ma, like
many other ``older orthogneisses'' in Alpine basement units. It hosts
a large proportion of inherited zircons, which were dated around 630 Ma,
a Panafrican age indicating the Gondwanan affiliation of the Sambuco
basement. The calc-alkaline Matorello pluton yielded ages around 300 Ma,
similar to numerous Late Carboniferous intrusions in other basement
units of the Lower Penninic (Monte Leone, Antigorio, Verampio) and
Helvetic domains (Gotthard and other External Crystalline Massifs).
Associated lamprophyric dykes are slightly younger (300-290 Ma), like
similar dykes sampled in gneiss blocks included in the sedimentary cover
of the underlying Antigorio nappe (290-285 Ma). The Cocco granodiorite
and Ruscada leucogranite, both intruding the basement of the
neighbouring Maggia nappe, yielded ages of ca. 300-310 Ma, identical
within errors to the age of the Matorello pluton. They are significantly
older than former age determinations. This age coincidence, coupled with
remarkable petrologic similarities between the Cocco and Matorello
granodiorites, strongly suggests paleogeographic proximity of the
Sambuco and Maggia nappes in Late Carboniferous times. In recent
publications these two nappes have been interpreted as belonging to
distinct Mesozoic paleogeographic domains: ``European'' for Sambuco
and ``Brian double dagger onnais'' for Maggia, separated by the
``Valais'' oceanic basin. In this case, the similarity of the
Matorello and Cocco intrusions would demonstrate the absence of any
significant transcurrent movement between these two continental domains.
Alternatively, according to a more traditional view, Sambuco and Maggia
might belong to a single large Alpine tectonic unit
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