568 research outputs found
Analytical solution of a generalized Penna model
In 1995 T.J.Penna introduced a simple model of biological aging. A modified
Penna model has been demonstrated to exhibit behaviour of real-life systems
including catastrophic senescence in salmon and a mortality plateau at advanced
ages. We present a general steady-state, analytic solution to the Penna model,
able to deal with arbitrary birth and survivability functions. This solution is
employed to solve standard variant Penna models studied by simulation.
Different Verhulst factors regulating both the birth rate and external death
rate are considered.Comment: 6 figure
A dog oviduct-on-a-chip model of serous tubal intraepithelial carcinoma
Ovarian cancer is the fifth cause of cancer-related mortality in women, with an expected 5-year survival rate of only 47%. High-grade serous carcinoma (HGSC), an epithelial cancer phenotype, is the most common malignant ovarian cancer. It is known that the precursors of HGSC originate from secretory epithelial cells within the Fallopian tube, which first develops as serous tubal intraepithelial carcinoma (STIC). Here, we used gene editing by CRISPR-Cas9 to knock out the oncogene p53 in dog oviductal epithelia cultured in a dynamic microfluidic chip to create an in vitro model that recapitulated human STIC. Similar to human STIC, the gene-edited oviduct-on-a-chip, exhibited loss of cell polarization and had reduced ciliation, increased cell atypia and proliferation, with multilayered epithelium, increased Ki67, PAX8 and Myc and decreased PTEN and RB1 mRNA expression. This study provides a biomimetic in vitro model to study STIC progression and to identify potential biomarkers for early detection of HGSC.</p
Distribution of resonances for open quantum maps
We analyze simple models of classical chaotic open systems and of their
quantizations (open quantum maps on the torus). Our models are similar to
models recently studied in atomic and mesoscopic physics. They provide a
numerical confirmation of the fractal Weyl law for the density of quantum
resonances of such systems. The exponent in that law is related to the
dimension of the classical repeller (or trapped set) of the system. In a
simplified model, a rigorous argument gives the full resonance spectrum, which
satisfies the fractal Weyl law. For this model, we can also compute a quantity
characterizing the fluctuations of conductance through the system, namely the
shot noise power: the value we obtain is close to the prediction of random
matrix theory.Comment: 60 pages, no figures (numerical results are shown in other
references
A aplicação precoce de nitrogênio em cobertura não aumenta o rendimento de grãos do trigo cultivado na presença do alumínio
Mineralogia e gênese de argissolos das Serras do Tabuleiro/Itajaí, Estado de Santa Catarina
PRODUÇÃO E AVALIAÇÃO DE BRIQUETES DE FINOS DE CARVÃO VEGETAL COMPACTADOS COM RESÍDUO CELULÓSICO PROVENIENTE DA INDÚSTRIA DE PAPEL E CELULOSE1
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