DNA replication timing data corroborate in silico human replication origin predictions

We develop a wavelet-based multiscale pattern recognition methodology to disentangle the replication- from the transcription-associated compositional strand asymmetries observed in the human genome. Comparing replication skew profiles to recent high-resolution replication timing data reveals that most of the putative replication origins that border the so-identified replication domains are replicated earlier than their surroundings whereas the central regions replicate late in the S phase. We discuss the implications of this first experimental confirmation of these replication origin predictions that are likely to be early replicating and active in most tissues

Caring for critically ill children Standards

Includes bibliographical references. Added t.p. in Welsh: Gofalu am blant difrifol wael; safonau. Parallel text in English and Welsh, printed tete-beche,Text in English WelshAvailable from British Library Document Supply Centre- DSC:m03/21287 / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo

XUTs are a class of Xrn1-sensitive antisense regulatory non-coding RNA in yeast

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