Effect of Pt doping on the critical temperature and upper critical field in YNi2-xPtxB2C (x=0-0.2)

We investigate the evolution of superconducting properties by doping non-magnetic impurity in single crystals of YNi2-xPtxB2C (x=0-0.2). With increasing Pt doping the critical temperature (Tc) monotonically decreases from 15.85K and saturates to a value ~13K for x>0.14. However, unlike conventional s-wave superconductors, the upper critical field (HC2) along both crystallographic directions a and c decreases with increasing Pt doping. Specific heat measurements show that the density of states (N(EF)) at the Fermi level (EF) and the Debye temperatures (Theta_D) in this series remains constant within the error bars of our measurement. We explain our results based on the increase in intraband scattering in the multiband superconductor YNi2B2C.Comment: ps file with figure

Computational and Experimental Study for Reducing Forebody Wake Effect by Proper Designing of a Slit cut Square Parachute used for Sonobuoy Drop

This paper discusses the design of a square parachute based on classical approach, computational analysis and experimentation. This parachute will be used to drop directional sonobuoy on the sea to locate and classify the submarines. Design improvements are brought out by providing slits into a solid square canopy of parachute to bring in more stability and minimum drift during descend. Specifically, the effect of upstream sonobuoy, RANS model, suspension line length, canopy size and slit size in flow structure were considered. The predicted drag coefficients obtained from CFD for square canopy with slit-cuts compared with the results of wind tunnel experiment and found that the increase in the suspension-line length and/or of the surface area of the parachute canopy helps in better stability and results in the minimum drag loss

A Rare Case of Lung Hypoplasia, Cardiac Anomalies and Ovarian Tumour in a Patient with MRKH Syndrome

Hypoplasia of the lung is an uncommon congenital abnormality of the respiratory system in contrast to Pulmonary agenesis. Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is the congenital absence of the upper two-thirds of the vagina and uterus with normal secondary sexual characteristics, ovary, and normal karyotype. Here we describe a case of left lung hypoplasia and congenital cardiac malformations with MRKH syndrome and Leiomyoma of the ovary. A 31-year-old female presented with cough with expectoration, left side chest pain and breathlessness for four years to Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER). She was evaluated for amenorrhea and diagnosed as MRKH syndrome and the patient underwent right side oophorectomy for right ovarian torsion with a tumour. Computed Tomography Pulmonary Angiogram (CTPA) and fiberoptic endoscopy were suggestive of left lung hypoplasia, and the patient was advised symptomatic treatment for lung hypoplasia and planned for vaginoplasty. Keywords: Pulmonary hypoplasia, Infertility, Mullerian aplasia, congenital bronchiectasis, Left-sided superior vena cava, ovarian Leiomyoma

Mathematical modeling of gonadotropin-releasing hormone signaling.

This is the author accepted manuscript. The final version is available from the publisher via the DOI in this record.Gonadotropin-releasing hormone (GnRH) acts via G-protein coupled receptors on pituitary gonadotropes to control of reproduction. These are Gq-coupled receptors that mediate acute effects of GnRH on the exocytotic secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as the chronic regulation of their synthesis. GnRH is secreted in short pulses and GnRH effects on its target cells are dependent upon the dynamics of these pulses. Here we overview GnRH receptors and their signaling network, placing emphasis on pulsatile signaling, and how mechanistic mathematical models and an information theoretic approach have helped further this field.This work was funded Project Grants from MRC (93447) and the BBSRC (J014699). KTA and MV gratefully acknowledge the financial support of the EPSRC via grant EP/N014391/1 and an MRC Biomedical Informatics Fellowship (MR/K021826/1), respectively

Surgical Stabilization of Femur Fractures in Post-Traumatic Hypoxemic Patients: When and Why?

Background: Post-traumatic hypoxemia can deteriorate during operative manipulations. Objectives: In the present study, criteria-based approach was applied to determine optimum conditions for femur surgery. The aim of this study was to optimize perioperative management of post-traumatic hypoxemia. Patients and Methods: In this prospective observational study, post-traumatic adults with PaO2 200 mmHg (FiO2 < 0.5, PEEP < 8 cm H2O). Results: A total of 31 adults (26 males and 5 females) with LIS of 0.1 to 2.5 (26 patients) and > 2.5 (five patients) at admission were recruited. Sixteen patients were admitted within 24 hours and 15 between 24 and 90 hours after injury. Thirteen patients were operated within 24 hours. Post-operative LIS was improved. No adverse sequels or mortality were seen. Conclusions: Appropriate surgical stabilization can be safely performed during established post-traumatic hypoxemia using a multidisciplinary approach, continuous monitoring, and serial investigations to diagnose fulminant pathology and associated injuries

A retrospective study of 296 cases of intra uterine fetal deaths at a tertiary care centre

Background: To identify the risk factors and to streamline preventive and management protocols for IUD.Methods: This was a retrospective study from January 2011 to December 2012 which was conducted at G.S.V.M. Medical College, Kanpur. IUD was defined as fetal death beyond 20 weeks of gestation and/or birth weight > 500g. Maternal and fetal records were analysed. Mode of delivery and associated complications were studied.Results: Total number of deliveries were 7310.Incidence of IUD at our centre was 40 per 1000. 55.73% were antepartum and 11.06% were intra partum. In 33.44% cases, no causes were identified. Among the identifiable causes, very severe anemia (16.55%) and hypertensive disorders (10.81%) were most common followed by placental causes (12.16%).Congenital malformations were responsible for 9.45% cases .Induction was done in 151 patients,111 patients had spontaneous onset of labour and caesarean section was done in 34 patients. The most devastating complication of IUD was DIC found in 14 patients (3.71%).Conclusions: The present study is an effort to compile a profile of maternal, fetal and placental causes culminating to IUD at our centre. This emphasizes the importance of proper antenatal care and identification of risk factors and its treatment. Institutional deliveries should be promoted to prevent intrapartum fetal deaths .A substantial number of IUD are still labeled as unexplained, hence cannot be prevented. Decrease in the incidence of IUD would significantly reduce the perinatal mortality