6 research outputs found
Classification of finite congruence-simple semirings with zero
Our main result states that a finite semiring of order >2 with zero which is
not a ring is congruence-simple if and only if it is isomorphic to a `dense'
subsemiring of the endomorphism semiring of a finite idempotent commutative
monoid.
We also investigate those subsemirings further, addressing e.g. the question
of isomorphy.Comment: 16 page
Distance Properties of Short LDPC Codes and their Impact on the BP, ML and Near-ML Decoding Performance
Parameters of LDPC codes, such as minimum distance, stopping distance,
stopping redundancy, girth of the Tanner graph, and their influence on the
frame error rate performance of the BP, ML and near-ML decoding over a BEC and
an AWGN channel are studied. Both random and structured LDPC codes are
considered. In particular, the BP decoding is applied to the code parity-check
matrices with an increasing number of redundant rows, and the convergence of
the performance to that of the ML decoding is analyzed. A comparison of the
simulated BP, ML, and near-ML performance with the improved theoretical bounds
on the error probability based on the exact weight spectrum coefficients and
the exact stopping size spectrum coefficients is presented. It is observed that
decoding performance very close to the ML decoding performance can be achieved
with a relatively small number of redundant rows for some codes, for both the
BEC and the AWGN channels
Structural Characterization of an S enantioselective Imine Reductase from Mycobacterium Smegmatis
NADPH-dependent imine reductases (IREDs) are enzymes capable of enantioselectively reducing imines to chiral secondary amines, which represent important building blocks in the chemical and pharmaceutical industry. Since their discovery in 2011, many previously unknown IREDs have been identified, biochemically and structurally characterized and categorized into families. However, the catalytic mechanism and guiding principles for substrate specificity and stereoselectivity remain disputed. Herein, we describe the crystal structure of S-IRED-Ms from Mycobacterium smegmatis together with its cofactor NADPH. S-IRED-Ms belongs to the S-enantioselective superfamily 3 (SFam3) and is the first IRED from SFam3 to be structurally described. The data presented provide further evidence for the overall high degree of structural conservation between different IREDs of various superfamilies. We discuss the role of Asp170 in catalysis and the importance of hydrophobic amino acids in the active site for stereospecificity. Moreover, a separate entrance to the active site, potentially functioning according to a gatekeeping mechanism regulating access and, therefore, substrate specificity is described
Segmentierte FlowâProzesse zur Ăberwindung von Limitierungen der GanzzellâBiokatalyse in Gegenwart von organischen Lösungsmitteln
Adebar N, Nastke A, Löwe J, Gröger H. Segmentierte FlowâProzesse zur Ăberwindung von Limitierungen der GanzzellâBiokatalyse in Gegenwart von organischen Lösungsmitteln. Angewandte Chemie. 2021;133(29):15997-16004.In der modernen Prozessentwicklung spielt Biokatalyse eine immer gewichtigere Rolle, wobei die Benutzung von Ganzzellkatalysatoren hĂ€ufig eine bevorzugte Form dieser Biokatalysatoren darstellt. Die Anwendung von Ganzzellkatalysatoren in organischen zweiphasigen Batch-Synthesen ist jedoch oft durch EinschrĂ€nkungen im Hinblick auf Stofftransfer, Emulsionsbildung, aufwĂ€ndiger Aufarbeitung und damit verbundenen geringen Ausbeuten beeintrĂ€chtigt. In diesem Beitrag zeigen wir, dass unter Zuhilfenahme von segmentierten Flow-Prozessen eine effiziente Ganzzellkatalyse in zweiphasigen Medien ermöglicht wird. Die LeistungsfĂ€higkeit solcher segmentierter Flow-Prozesse ist dabei exemplarisch an drei unterschiedlichen Biotransformationen dargestellt. Zum Beispiel wurde in einem solchen Flow-Prozess eine 3-fache Steigerung des Umsatzes von 34â% auf >99â% verbunden mit einer erheblich vereinfachten Aufarbeitung erzielt, die zu einer 1.5-fachen Steigerung der Ausbeute von 44â% auf 65â% im Vergleich zum analogen Batch-Prozess fĂŒhrte