The Technique of Automated Design of Technological Objects with the Application of Artificial Intelligence Elements

The chapter describes the methodology of using artificial intelligence methods to build an integrated environment for computer-aided design components of technological objects based on their classification, integration and configuration. It describes the formation of CAD based on the object-oriented approach, methods of configuring the integrated environment and the organization of single information space. The configuration of the system components and the methodology for organizing the interaction of CAD components, obtaining the final CAD architecture, focused on solving the problem, is shown. The application of the Mamdani method for the formal description of project operations and the use of genetic algorithms to optimize the operational parameters of the process and the design of the technological machine are described

The Creation of Resistant Berries’ Agrobiocenosis

In conditions of increasing differences in the hydrothermal regime of the environment, all known adaptation mechanisms should be used fully, as at the level of individual varieties and at agrobiocenosis in general. The modern gardener needs high-productive, adapted to the growing conditions varieties of the Fragária × ananássa Durh. The resistant varieties of the Fragária × ananássa Durh. to negative environmental conditions is a basic characteristic, which shows an economic value and the effectiveness of their cultivation in an actual zone. The main physiological and biochemical indicators of resistance during autumn hardening and after temperature stress in winter are changes in the antioxidant system, interruptions of the protein-carbohydrate complex, accumulation products of membran’s lipoperoxidation, and changes in the fractional composition of water in leaves. The Fragária × ananássa Durh. production process is characterized by the following physiological parameters: pigment analysis, photochemical activity of isolated chloroplasts, respiration, and net photosynthesis productivity. Studies of physiological and biochemical resources of resistance to abiotic stress factors and productivity of Fragária × ananássa Durh. are shown. As a result of the carried studies, perspective variety of the Fragária × ananássa Durh. (“Tzaritza”) was identified for the creation of resistance berries’ agrobiocenosis

Ultrasonic predictors of macrosomia in gestational diabetes mellitus

BACKGROUND: The basis of early ultrasound (US) diagnosis of diabetic fetopathy (DF) in pregnant with gestational diabetes mellitus (GDM) is the forehanded detection of macrosomia, especially its asymmetric forms. In pregnant with GDM on a diet therapy, the detection of macrosomia may be an indication for starting the insulin therapy. In pregnant with hyperglycemia due to mutation in the glucokinase gene (GCK), US fetal growth dynamics helps to assume the fetal genotype, as well as to stratify the risks of insulin therapy. AIM: To determine the prognostic significance of asymmetric form of macrosomia and the value of the coefficients of proportionality for the diagnosis of DF in pregnant with GDM, including hyperglycemia due to mutation in the GCK gene. MATERIALS AND METHODS: US fetometry was performed in 95 pregnant with GDM (including 22 pregnant with hyperglycemia caused by mutation in the GCK gene) (main group) and 427 healthy pregnant women (control group). Estimated fetal weight, standard fetometric indicators and coefficients of proportionality were evaluated. Retrospective analysis of US predictors of macrosomia was carried out after evaluating the weight of the newborn and clarifying the signs of DF. RESULTS: In the group with GDM, 51 (53.7%) pregnant had children with phenotypic symptoms of DF, including macrosomia – 66,7% (34 children). We found statistically significant differences in fetal weight between the control group and the main group who gave birth to children with DF starting from 32 weeks. The coefficients of proportionality (femur length/abdominal circumference and the head circumference/abdominal circumference), characterizing the formation of the asymmetric macrosomia were significantly from 34 weeks (Р<0,05). CONCLUSION: The most effective predictive fetometric indicators for the diagnosis of fetal macrosomia are the dimensions of fetal abdomen and fetal weight > 90 percentile for gestational age. A specific sign of DF in pregnant with GDM is the asymmetric macrosomia. In pregnant with a mutation in the GCK gene, the tendency to macrosomia was revealed only in the absence of a mutation in the fetus, but insulin therapy in the presence of a similar mutation in fetus did not lead to a significant decrease in its percentile ranges

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Method of Hydrogenous Fuel Usage to Increase the Efficiency in Tandem Diverse Temperature Oxidation System

This paper presents the results of estimation energy efficiency, the collation data of thermodynamic calculations and data on material balance for an assessment of electric and thermal components in considered ways to use convention products, performance enhancement in the tandem system containing the high-temperature fuel cell and the low-temperature fuel cell with full heat regeneration for hydrogenous fuel (CH4). The overall effective efficiency (ηΣef. making full use of the recovered heat) considered tandem system depends on the efficiency of its constituent fuel cells. The overall effective efficiency of the tandem installation including the fuel converter, separating system, high-temperature oxidation system, and hydrogen disposal system in case of fuel use in the low-temperature fuel cell, is higher than for each of the fuel cell elements separately

Method of Hydrogenous Fuel Usage to Increase the Efficiency in Tandem Diverse Temperature Oxidation System

This paper presents the results of estimation energy efficiency, the collation data of thermodynamic calculations and data on material balance for an assessment of electric and thermal components in considered ways to use convention products, performance enhancement in the tandem system containing the high-temperature fuel cell and the low-temperature fuel cell with full heat regeneration for hydrogenous fuel (CH4). The overall effective efficiency (ηΣef. making full use of the recovered heat) considered tandem system depends on the efficiency of its constituent fuel cells. The overall effective efficiency of the tandem installation including the fuel converter, separating system, high-temperature oxidation system, and hydrogen disposal system in case of fuel use in the low-temperature fuel cell, is higher than for each of the fuel cell elements separately

Anthocyanins and catechins in the berries of new strawberry cultivars grown in the conditions of the Orel region

The results of the study of 20 new strawberry cultivars grown in the conditions of the Central part of Russia (Orel region), according to the content of anthocyanins, catechins and the total number of polyphenols in berries, are presented. Anthocyanins and catechins are representatives of the main group of phenolic compounds, flavonoids that have a therapeutic and preventive effect on the human body. The purpose of the research is to identify the best genotypes for breeding for an improved chemical composition of berries. The determination of phenolic compounds was carried out by the photometric method. The content of anthocyanins in strawberries varied depending on the cultivar to an average degree (V=16.3%) and amounted to 51.1±1.9 mg/100 g with a range of variation from 40.1 to 70.2 mg/100 g. A high content of anthocyanins (mg/100 g) was observed in Rusich (70.2), Solovushka (64.2), Darselect (62.5), Tsaritsa (59.5), Rubino civ (57.9), Sonata (55.4), Alpha (54.5), Honeoye (51.8). The average content of catechins in the berries of the studied group of cultivars also changed to an average degree (V=22.2%) from 71.4 to 174.6 mg/100 g with an average c value of 124.9±6.2 mg/100 g. The high content of catechins in berries was found in Rusich (136,2), Clery (132,0), Rubino civ (137,4), Sara (137,7), Vima Kimberly (139,5), Dezy (152,5), Sonata (164,9), Solovushka (168,2) and Alpha (174,6). There was no correlation between the accumulation of anthocyanins and catechins in strawberries (r=+0.149). According to the total number of polyphenols (more than 500 mg/100 g) in the berries, Alpha, Rusich, Solovushka, Dezy and Rubino civ are distinguished

Technological Decision to Renewable Energy Usage Biogas for Off-grid Systems Consumption

This paper presents the results of the energy experiments based on electrochemical researches and the thermodynamic calculations, which are carried out on the hydrogenous fuel with the residual content of methane obtained from biogas selected organic waste. Energy indicators are examined in comparison to electrolysis hydrogen. The use of technical and electro physical indicators together with parameters of the fuel operating allowed assessing energy efficiency the module reformer - fuel cell running on a non-standard hydrogenous fuel. Numerical characteristic the efficiency of workflows fuel system reformer – fuel cell is about 39%. To operate the power installation with a predetermined capacity amount used of hydrogenous fuel is comparable to required electrolysis hydrogen amount. Shown the possibility of creation the systems of power supply based on new hydrogen technologies using renewable energy resources local waste. Confirms the relatively high efficiency the usage of hydrogenous fuel for the tasks of off-grid systems consumption