Research on the Competitiveness of Hubei Manufacturing Post Financial Crisis Era——Panel Data of 2008~2011

With Location Quotient and Shift-Share-Method, this paper evaluated the competitiveness of manufacturing industries in Hubei province post Financial Crisis Era based on the panel data from 2008 to 2011of Output Value of Industrial Products Sales and Delivery Value for Export of Large and Medium Scale Industrial Enterprises. On basis of these, this paper also put forward some countermeasures to improve the competitiveness of manufacturing industry of Hubei province

Teaching Children with Autism to Understand Metaphors

The purpose of this study was to evaluate the effects of an instructional procedure on the acquisition and generalization of metaphorical understanding for children with autism spectrum disorder. Three students (two boys, one girl, 5-8 years old) participated but only two completed the study. A multiple-probe design across two behaviors and three participants was used. The metaphors were categorized by topography: metaphors involving physical features and metaphors involving abstract properties. The instruction consisted of intraverbal training using echoic prompts, picture prompts, and textual prompts. The results indicated that the instruction was effective in establishing metaphorical understanding of target metaphors. Generalized understanding to untaught metaphors occurred for the two students who completed the study, and all metaphors were maintained at a relatively high level for two months following the instruction

Potential of Core-Collapse Supernova Neutrino Detection at JUNO

JUNO is an underground neutrino observatory under construction in Jiangmen, China. It uses 20kton liquid scintillator as target, which enables it to detect supernova burst neutrinos of a large statistics for the next galactic core-collapse supernova (CCSN) and also pre-supernova neutrinos from the nearby CCSN progenitors. All flavors of supernova burst neutrinos can be detected by JUNO via several interaction channels, including inverse beta decay, elastic scattering on electron and proton, interactions on C12 nuclei, etc. This retains the possibility for JUNO to reconstruct the energy spectra of supernova burst neutrinos of all flavors. The real time monitoring systems based on FPGA and DAQ are under development in JUNO, which allow prompt alert and trigger-less data acquisition of CCSN events. The alert performances of both monitoring systems have been thoroughly studied using simulations. Moreover, once a CCSN is tagged, the system can give fast characterizations, such as directionality and light curve

Detection of the Diffuse Supernova Neutrino Background with JUNO

As an underground multi-purpose neutrino detector with 20 kton liquid scintillator, Jiangmen Underground Neutrino Observatory (JUNO) is competitive with and complementary to the water-Cherenkov detectors on the search for the diffuse supernova neutrino background (DSNB). Typical supernova models predict 2-4 events per year within the optimal observation window in the JUNO detector. The dominant background is from the neutral-current (NC) interaction of atmospheric neutrinos with 12C nuclei, which surpasses the DSNB by more than one order of magnitude. We evaluated the systematic uncertainty of NC background from the spread of a variety of data-driven models and further developed a method to determine NC background within 15\% with {\it{in}} {\it{situ}} measurements after ten years of running. Besides, the NC-like backgrounds can be effectively suppressed by the intrinsic pulse-shape discrimination (PSD) capabilities of liquid scintillators. In this talk, I will present in detail the improvements on NC background uncertainty evaluation, PSD discriminator development, and finally, the potential of DSNB sensitivity in JUNO

Real-time Monitoring for the Next Core-Collapse Supernova in JUNO

Core-collapse supernova (CCSN) is one of the most energetic astrophysical events in the Universe. The early and prompt detection of neutrinos before (pre-SN) and during the SN burst is a unique opportunity to realize the multi-messenger observation of the CCSN events. In this work, we describe the monitoring concept and present the sensitivity of the system to the pre-SN and SN neutrinos at the Jiangmen Underground Neutrino Observatory (JUNO), which is a 20 kton liquid scintillator detector under construction in South China. The real-time monitoring system is designed with both the prompt monitors on the electronic board and online monitors at the data acquisition stage, in order to ensure both the alert speed and alert coverage of progenitor stars. By assuming a false alert rate of 1 per year, this monitoring system can be sensitive to the pre-SN neutrinos up to the distance of about 1.6 (0.9) kpc and SN neutrinos up to about 370 (360) kpc for a progenitor mass of 30$M_{\odot}$ for the case of normal (inverted) mass ordering. The pointing ability of the CCSN is evaluated by using the accumulated event anisotropy of the inverse beta decay interactions from pre-SN or SN neutrinos, which, along with the early alert, can play important roles for the followup multi-messenger observations of the next Galactic or nearby extragalactic CCSN.Comment: 24 pages, 9 figure

Monotonically Iterative Method for the Cantilever Beam Equations

In this paper, we consider the existence of extremal solutions for the nonlinear fourth-order differential equation. By use of a new comparison result, some sufficient conditions for the existence of extremal solutions are established by combining the monotone iterative technique and the methods of lower and upper solutions. Finally, an example is given to illustrate the validity of our main results

Design of Wideband Dual-Polarized Planar Antenna Using Multimode Concept

A wideband dual-polarized planar antenna is designed and analyzed by using the theory of characteristic modes (TCM). The eigenvalue, eigencurrent, characteristic pattern, and modal weighting coefficient are analyzed to bring physical insight to this kind of antenna. The results demonstrate that there are two modes resonant in the operating band for each polarization, which have been combined to form a wider frequency band. A bandwidth of 60.2% (1.72–3.2 GHz) for VSWR < 1.5 with high isolation of 32 dB is achieved simultaneously. The size of the radiator structure is 0.33λ0 × 0.33λ0 × 0.22λ0 (λ0 refers to the center operating frequency)

Ecological Health Assessment with the Combination Weight Method for the River Reach after the Retirement and Renovation of Small Hydropower Stations

This study aimed to effectively evaluate the ecological restoration of the river reach where a small hydropower station was retired or renovated. An ecological health index system was constructed based on the environmental characteristics of the upstream and downstream of the small hydropower station after its retirement and renovation. Based on the combination weighting concept of game theory, the combination weights were obtained by the comprehensive analytic hierarchy process (subjective weight) and entropy method (objective weight). This ecological health assessment with fuzzy comprehensive evaluation was applied to assess the health status of Shimen (dam removal) and Changqiao (renovation in ecological flow) reaches of the Tufang River in Changting County, China. The results showed that the ecological health assessment index system proposed in this study was comprehensive and reasonable, and the revision degree of the hydropower station obviously influenced the process of ecological river restoration. The findings from this study would benefit for the rational utilization of water resources and the river ecological health maintenance in mountainous areas

H3K36 trimethylation mediated by SETD2 regulates the fate of bone marrow mesenchymal stem cells.

During the aging process, bone marrow mesenchymal stem cells (BMSCs) exhibit declined osteogenesis accompanied by excess adipogenesis, which will lead to osteoporosis. Here, we report that the H3 lysine 36 trimethylation (H3K36me3), catalyzed by histone methyltransferase SET-domain-containing 2 (SETD2), regulates lineage commitment of BMSCs. Deletion of Setd2 in mouse bone marrow mesenchymal stem cells (mBMSCs), through conditional Cre expression driven by Prx1 promoter, resulted in bone loss and marrow adiposity. Loss of Setd2 in BMSCs in vitro facilitated differentiation propensity to adipocytes rather than to osteoblasts. Through conjoint analysis of RNA sequencing (RNA-seq) and chromatin immunoprecipitation sequencing (ChIP-seq) data, we identified a SETD2 functional target gene, Lbp, on which H3K36me3 was enriched, and its expression was affected by Setd2 deficiency. Furthermore, overexpression of lipopolysaccharide-binding protein (LBP) could partially rescue the lack of osteogenesis and enhanced adipogenesis resulting from the absence of Setd2 in BMSCs. Further mechanistic studies demonstrated that the trimethylation level of H3K36 could regulate Lbp transcriptional initiation and elongation. These findings suggest that H3K36me3 mediated by SETD2 could regulate the cell fate of mesenchymal stem cells (MSCs) in vitro and in vivo, indicating that the regulation of H3K36me3 level by targeting SETD2 and/or the administration of downstream LBP may represent a potential therapeutic way for new treatment in metabolic bone diseases, such as osteoporosis