Cimetna kiselina i njeni derivati

Cinnamic acid (3-phenylpropenoic or phenylacrylic acid) and its derivatives occur naturally in a number of plants. Th ey are precursors in the biosynthetic pathways of many alkaloids, aromatic amino acids, phenylpropanoids, styrenes, stilbenes, coumarins, lignins and fl avonoids, and are present in various essential oils, gums and balsams. Cinnamic acid derivatives are used in large quantities in the food, cosmetic and pharmaceutical industries. In addition, they possess a variety of pharmacological activities: antimicrobial, antitubercular, antioxidative, antimicrobial, antimalarial, antiviral, antidiabetic, hepatoprotective, antidepressant, anxiolytic, hypolipemic, anti-infl ammatory and cytostatic activities. Several drugs with cinnamic acid motifs are used in modern therapy (panobinostat, belinostat, cinanserin, tranilast, ozagrel and entacapone)

Lijekovi s fluorom

Naturally occurring organofluorine compounds are extremely rare. On the other hand, there are almost million of synthetic organofluorine compounds and their number is growing rapidly. Due to their unique physicochemical and biological characteristics, they are widely used as pharmaceuticals, materials and agrochemicals. Strategic incorporation of fluorine in drug-candidate became a common strategy in drug design and development. Organofluorine compounds have increased lipophilicity, membrane permeability, thermal and metabolic stability, and enhanced binding affinity to the targeted macromolecules compared to their nonfluorinated analogs. About 20 % of the currently marketed drugs contain fluorine. Organofluorine drugs are particularly popular among inhalation anesthetics, glucocorticoids, anticancer drugs, neuroleptics and antidepressants. Many blockbuster pharmaceuticals such as fluoxetine, rosuvastatin, atorvastatin, celecoxib, sitagliptin etc. contain fluorine. 18F-radiolabeled 2-fl uoro-2-deoxyglucose, florbetapir, florbetaben, flutemetamol and fluorodopa are used in positron emission tomography (PET) as medical diagnostics of neurodegenerative diseases and cancer. Inorganic compound sodium fluoride is used for the prevention of tooth decay. The fluoride enhances the strength of teeth by the formation of fluorapatite, a naturally occurring component of tooth enamel. Sodium fluoride, hexafluorosilicic acid and sodium hexafluorosilicate are commonly used for water fluoridation, while sodium and tin(II) fluoride are components of toothpaste

Workshop Murska Sobota, North of Lendavska Street

The urban design workshop "North of Lendavska Street" addressed the extensive area north of downtown Murska Sobota. The area is undergoing intensive transformation. Service and commercial programmes are occupying abandoned industrial and military facilities and filling the empty spaces between. Due to its location near the city centre and its proximity to natural surroundings across the Ledava stream, the area is also attractive for housing and recreation. The existing residential neighbourhood to the south has poor living conditions due to inadequate open space and a badly organised traffic system. The workshop, organised by the Municipality of Murska Sobota, involved groups of students from three Slovene faculties and two groups of practicing architects. The groups proposed designs and strategies for possible future urban development and formed a joint professional platform to prepare spatial planning documents

Examination of weld defects by computed tomography

Defects in metal arc gas (MAG) welds made in S235JR low carbon steel of 6 mm thickness were examined. A sample containing lack of fusion (LOF) and pores was examined by computed tomography – CT. The computed tomography examination was performed in order to define LOF size and position as well as dimensions and distribution of accompanying pores in the weld metal

Reactions with N-(1-benzotriazolylcarbonyl)-amino acids. IV. The use of N-(1-benzotriazolylcarbonyl)-amino acid derivates in peptide synthesis

The use of the 1-benzotriazolylearbonyl-(Bte)-group as an N-protecting and N-activating group in the synthesis of peptides was investigated. Removal of the Btc group from N-Btc-amino acids, their esters and amides under acidic conditions is possible, but has no advantages over removal of benzyloxyearbonyl-(Z)-group. N-Btc-amino acid esters react with Z-amino acids or Z-dipeptides yielding Z-dipeptide and Z-tripeptide esters, respcetively. This process is aceompanied with separation of benzotriazole and C02. Advantages and disadvantages of this method of peptide bond formation are discussed

Reaktionen mit N-(1- Benzotriazolylcarbonyl)-aminosauren.III Synthese von Aminosaure-estern

N-(l-Benzotriazolylcarbonyl)-aminosauren· (Ia-f) reagieren mit Alkoholen unter Abspaltung von Benzotriazol und Kohlendioxid zu den entsprechenden Aminosaure-Estern. (Ila-i). Die Reaktion verlauft bei Raumtemperatur und wird durch Zugabe von Triethylamin beschleunigt