Specification and enforcement of flexible security policy for active cooperation

Interoperation and services sharing among different systems are becoming new paradigms for enterprise collaboration. To keep ahead in strong competition environments, an enterprise should provide flexible and comprehensive services to partners and support active collaborations with partners and customers. Achieving such goals requires enterprises to specify and enforce flexible security policies for their information systems. Although the area of access control has been widely investigated, current approaches still do not support flexible security policies able to account for different weighs that typically characterize the various attributes of the requesting parties and transactions and reflect the access control criteria that are relevant for the enterprise. In this paper we propose a novel approach that addresses such flexibility requirements while at the same time reducing the complexity of security management. To support flexible policy specification, we define the notion of restraint rules for authorization management processes and introduce the concept of impact weight for the conditions in these restraint rules. We also introduce a new data structure for the encoding of the condition tree as well as the corresponding algorithm for efficiently evaluating conditions. Furthermore, we present a system architecture that implements above approach and supports interoperation among heterogeneous platforms

Augmented Graphene Quantum Dot-Light Irradiation Therapy for Bacteria-Infected Wounds

This paper proposes a highly efficient antibacterial system based on a synergistic combination of photodynamic therapy, photothermal therapy, and chemotherapy. Chitosan oligosaccharide functionalized graphene quantum dots (GQDs-COS) with short-term exposure to 450 nm visible light are used to promote rapid healing in bacteria-infected wounds. The GQDs undergo strong photochemical transformation to rapidly produce radical oxygen species and heat under light illumination, while the COS has an innate antimicrobial ability. Moreover, the positively charged GQDs-COS can easily capture bacteria via electrostatic interactions and kill Gram-positive and Gram-negative bacteria by multivalent interactions and synergistic effects. The antibacterial action of this nanocomposite causes irreversible damage to outer and inner bacterial membranes, resulting in cytoplasm leakage and death. The system has good hemocompatibility and low cytotoxicity and can improve the healing of infected wounds, as demonstrated by the examination of pathological tissue sections and inflammatory markers. These results suggest that GQDs anchored with bioactive molecules are a potential photo-activated antimicrobial strategy for anti-infective therapy