Essential drugs production in Brazil, Russia, India, China and South Africa (BRICS): opportunities and challenges

The objective of this work is to elucidate various essential drugs in the Brazil, Russia, India, China and South Africa (BRICS) countries. It discusses the opportunities and challenges of the existing biotech infrastructure and the production of drugs and vaccines in member states of the BRICS. This research is based on a systematic literature review between the years 2000 and 2014 of documents retrieved from the databases Embase, PubMed/ Medline, Global Health, and Google Scholar, and the websites of relevant international organizations, research institutions and philanthropic organizations. Findings vary from one member state to another. These include useful comparison between the BRICS countries in terms of pharmaceuticals expenditure versus total health expenditure, local manufacturing of drugs/vaccines using technology and know-how transferred from developed countries, and biotech entrepreneurial collaborations under the umbrella of the BRICS region. This study concludes by providing recommendations to support more of inter collaborations among the BRICS countries as well as between BRICS and many developing countries to shrink drug production costs. In addition, this collaboration would also culminate in reaching out to poor countries that are not able to provide their communities and patients with cost-effective essential medicines

Essential Drugs Production in Brazil, Russia, India, China and South Africa (BRICS): Opportunities and Challenges

The objective of this work is to elucidate various essential drugs in the Brazil, Russia, India, China and South Africa (BRICS) countries. It discusses the opportunities and challenges of the existing biotech infrastructure and the production of drugs and vaccines in member states of the BRICS. This research is based on a systematic literature review between the years 2000 and 2014 of documents retrieved from the databases Embase, PubMed/Medline, Global Health, and Google Scholar, and the websites of relevant international organizations, research institutions and philanthropic organizations. Findings vary from one member state to another. These include useful comparison between the BRICS countries in terms of pharmaceuticals expenditure versus total health expenditure, local manufacturing of drugs/vaccines using technology and know-how transferred from developed countries, and biotech entrepreneurial collaborations under the umbrella of the BRICS region. This study concludes by providing recommendations to support more of inter collaborations among the BRICS countries as well as between BRICS and many developing countries to shrink drug production costs. In addition, this collaboration would also culminate in reaching out to poor countries that are not able to provide their communities and patients with cost-effective essential medicines

Abstract Applications of artificial intelligence in bioinformatics: A review

Artificial intelligence (AI) has increasingly gained attention in bioinformatics research and computational molecular biology. With the availability of different types of AI algorithms, it has become common for the researchers to apply the off-shelf systems to classify and mine their databases. At present, with various intelligent methods available in the literature, researchers are facing difficulties in choosing the best method that could be applied to a specific data set. Researchers need tools, which present the data in a comprehensible fashion, annotated with context, estimates of accuracy and explanation. This article aims to review the use of AI in the areas of bioinformatics and computational molecular biology (DNA sequencing). These areas have risen from the needs of biologists to utilize and help interpret the vast amounts of data that are constantly being gathered in genomic research. The underlying motivation for many of the bioinformatics and DNA sequencing approaches is the evolution of organisms and the complexity of working with erroneous data. This article also describes the kind of software programs which were developed by the research community in order to (1) search, classify and mine different available biological databases; (2) simulate biological experiments with and without errors

Analysis of the Hox epigenetic code

Archetypes of histone modifications associated with diverse chromosomal states that regulate access to DNA are leading the hypothesis of the histone code (or epigenetic code). However, it is still not evident how these post-translational modifications of histone tails lead to changes in chromatin structure. Histone modifications are able to activate and/or inactivate several genes and can be transmitted to next generation cells due to an epigenetic memory. The challenging issue is to identify or “decrypt” the code used to transmit these modifications to descent cells. Here, an attempt is made to describe how histone modifications operate as part of histone code that stipulates patterns of gene expression. This papers emphasizes particularly on the correlation between histone modifications and patterns of Hox gene expression in Caenorhabditis elegans. This work serves as an example to illustrate the power of the epigenetic machinery and its use in drug design and discovery