13 research outputs found
MYCN oncogene and angiogenesis: Down-regulation of endothelial growth inhibitors in human neuroblastoma cells.
MYCN oncogene and angiogenesis: Down-regulation of endothelial growth inhibitors in human neuroblastoma cells.
MYCN oncogene and angiogenesis: Down-regulation of endothelial growth inhibitors in human neuroblastoma cells - Purification, structural, and functional characterization
N-myc oncogene overexpression down-regulates leukemia inhibitory factor in neuroblastoma
N-myc oncogene overexpression down-regulates leukemia inhibitory factor in neuroblastoma
Variability and repeatability of noctule bat migration in Central Europe: Evidence for partial and differential migration
N-myc oncogene overexpression down-regulates IL-6; evidence that IL-6 inhibits angiogenesis and supresses neuroblastoma tumor growth
Angiogenesis is an indispensable prerequisite for the progression and metastasis of solid malignancies. Tumor angiogenesis appears to be governed by alterations of tumor suppressor or oncogenes operant in a broad range of tumors. We have addressed this issue in neuroblastoma, a malignancy characterized by the near-exclusive amplification and overexpression of the N-Myc oncogene. Here, we report that N-Myc overexpression results in down-regulation of interleukin-6 (IL-6) and that IL-6 is an inhibitor of endothelial cell proliferation and VEGF-induced rabbit corneal angiogenesis. STAT3 is instrumental for IL-6 activity as infection with adenoviruses expressing a phosphorylation deficient STAT3 mutant renders endothelial cells insensitive to the antiproliferative action of IL-6. Finally, though IL-6 does not influence neuroblastoma cell growth, IL-6-expressing xenograft tumors in mice exhibit reduced neovascularization and suppressed growth. Our data shed new light on the mechanisms by which N-myc oncogene amplification enhances the malignant phenotype in neuroblastomas