1,339 research outputs found
Transcriptomics reveal an integrative role for maternal thyroid hormones during zebrafish embryogenesis
Thyroid hormones (THs) are essential for embryonic brain development but the genetic mechanisms involved in the action of maternal THs (MTHs) are still largely unknown. As the basis for understanding the underlying genetic mechanisms of MTHs regulation we used an established zebrafish monocarboxylic acid transporter 8 (MCT8) knock-down model and characterised the transcriptome in 25hpf zebrafish embryos. Subsequent mapping of differentially expressed genes using Reactome pathway analysis together with in situ expression analysis and immunohistochemistry revealed the genetic networks and cells under MTHs regulation during zebrafish embryogenesis. We found 4,343 differentially expressed genes and the Reactome pathway analysis revealed that TH is involved in 1681 of these pathways. MTHs regulated the expression of core developmental pathways, such as NOTCH and WNT in a cell specific context. The cellular distribution of neural MTH-target genes demonstrated their cell specific action on neural stem cells and differentiated neuron classes. Taken together our data show that MTHs have a role in zebrafish neurogenesis and suggest they may be involved in cross talk between key pathways in neural development. Given that the observed MCT8 zebrafish knockdown phenotype resembles the symptoms in human patients with Allan-Herndon-Dudley syndrome our data open a window into understanding the genetics of this human congenital condition.Portuguese Fundacao para Ciencia e Tecnologia (FCT) [PTDC/EXPL/MARBIO/0430/2013]; CCMAR FCT Plurianual financing [UID/Multi/04326/2013]; FCT [SFRH/BD/111226/2015, SFRH/BD/108842/2015, SFRH/BPD/89889/2012]; FCT-IF Starting Grant [IF/01274/2014]info:eu-repo/semantics/publishedVersio
First Observation of barB0 to D*0 pi+pi+pi-pi- Decays
We report on the observation of B0bar -> D*0 pi+ pi+ pi- pi- decays. The
branching ratio is (0.30 +/- 0.07 +/- 0.06)%. Interest in this particular mode
was sparked by Ligeti, Luke and Wise who propose it as a way to check the
validity of factorization tests in B0bar -> D*+ pi+ pi- pi- pi0 decays.Comment: 11 pages postscript, also available through
http://w4.lns.cornell.edu/public/CLNS, Version to appear in Phys. Rev.
Search for a Scalar Bottom Quark with Mass 3.5-4.5 GeV/
We report on a search for a supersymmetric meson with mass
between 3.5 and 4.5 GeV/ using 4.52 of integrated
luminosity produced at GeV, just below the threshold, and collected with the CLEO detector. We find no evidence
for a light scalar bottom quark.Comment: 10 pages postscript, also available through
http://w4.lns.cornell.edu/public/CLN
Branching Fractions of tau Leptons to Three Charged Hadrons
From electron-positron collision data collected with the CLEO detector
operating at CESR near \sqrt{s}=10.6 GeV, improved measurements of the
branching fractions for tau decays into three explicitly identified hadrons and
a neutrino are presented as {\cal
B}(\tau^-\to\pi^-\pi^+\pi^-\nu_\tau)=(9.13\pm0.05\pm0.46)%, {\cal B}(\tau^-\to
K^-\pi^+\pi^-\nu_\tau)=(3.84\pm0.14\pm0.38)\times10^{-3}, {\cal B}(\tau^-\to
K^-K^+\pi^-\nu_\tau)=(1.55\pm0.06\pm0.09)\times10^{-3}, and {\cal B}(\tau^-\to
K^-K^+K^-\nu_\tau)<3.7\times10^{-5} at 90% C.L., where the uncertainties are
statistical and systematic, respectively.Comment: 10 pages postscript, also available through
http://w4.lns.cornell.edu/public/CLNS, to appear in Phys. Rev. Let
Study of Charmless Hadronic B Meson Decays to Pseudoscalar-Vector Final States
We report results of searches for charmless hadronic B meson decays to
pseudoscalar(pi^+-,K^+-,Pi^0 or Ks^0)-vector(Rho, K* or Omega) final states.
Using 9.7 million BBbar pairs collected with the CLEO detector, we report first
observation of B^- --> Pi^-Rho^0, B^0 --> Pi^+-Rho^-+ and B^- --> Pi^-Omega,
which are expected to be dominated by hadronic b --> u transitions. The
measured branching fractions are (10.4+3.3-3.4+-2.1)x10^-6,
(27.6+8.4-7.4+-4.2)x10^-6 and (11.3+3.3-2.9+-1.4)x10^-6, respectively.
Branching fraction upper limits are set for all the other decay modes
investigated.Comment: 10 pages postscript, also available through
http://w4.lns.cornell.edu/public/CLN
Bounds on the CP Asymmetry in Like-Sign Dileptons from Meson Decays
We have measured the charge asymmetry in like-sign dilepton yields from B^0
B^0-bar meson decays using the CLEO detector at the Cornell Electron Storage
Ring. We find a_ll = [N(l+l+) - N(l-l-)]/[N(l+l+) + N[l-l-)] = +0.013 +/- 0.050
+/- 0.005 . We combine this result with a previous, independent measurement and
obtain Re(epsilon_B)/(1+|epsilon_B|^2) = +0.0035 +/- 0.0103 +/- 0.0015
(uncertainties are statistical and systematic, respectively) for the CP
impurity parameter, epsilon_B.Comment: 11 pages postscript, also available through
http://w4.lns.cornell.edu/public/CLN
Observation of New States Decaying into
Using 13.7 fb^{-1} of data recorded by the CLEO detector at CESR, we
investigate the spectrum of charmed baryons which decay into Lambda_c^+ pi^-
pi^+ and are more massive than the Lambda_{c1} baryons. We find evidence for
two new states: one is broad and has an invariant mass roughly 480 MeV above
that of the Lambda_c^+; the other is narrow with an invariant mass of 596 +- 1
+- 2 MeV above the Lambda_c^+ mass. These results are preliminary.Comment: 11 pages postscript, also available through
http://w4.lns.cornell.edu/public/CLN
A Search for Charmless Decays
We have studied two-body charmless decays of the meson into the final
states , , , , , , and
using only decay modes with charged daughter particles. Using 9.7 million pairs collected with the CLEO detector, we place 90% confidence level
upper limits on the branching fractions, , depending
on final state and polarization.Comment: 8 pages postscript, also available through
http://w4.lns.cornell.edu/public/CLN
Rate Measurement of and Constraints on Mixing
We present an observation and rate measurement of the decay D0 -> K+pi-pi0
produced in 9/fb of e+e- collisions near the Upsilon(4S) resonance. The signal
is inconsistent with an upward fluctuation of the background by 4.9 standard
deviations. We measured the rate of D0 -> K+pi-pi0 normalized to the rate of
D0bar -> K+pi-pi0 to be 0.0043 +0.0011 -0.0010 (stat) +/- 0.0007 (syst). This
decay can be produced by doubly-Cabibbo-suppressed decays or by the D0 evolving
into a D0bar through mixing, followed by a Cabibbo-favored decay to K+pi-pi0.
We also found the CP asymmetry A=(8 +25 -22)% to be consistent with zero.Comment: 10 pages postscript, also available through
http://w4.lns.cornell.edu/public/CLN
Hadronic Structure in the Decay
We report on a study of the invariant mass spectrum of the hadronic system in
the decay tau- -> pi- pi0 nu_tau. This study was performed with data obtained
with the CLEO II detector operating at the CESR e+ e- collider. We present fits
to phenomenological models in which resonance parameters associated with the
rho(770) and rho(1450) mesons are determined. The pi- pi0 spectral function
inferred from the invariant mass spectrum is compared with data on e+ e- -> pi+
pi- as a test of the Conserved Vector Current theorem. We also discuss the
implications of our data with regard to estimates of the hadronic contribution
to the muon anomalous magnetic moment.Comment: 39 pages postscript, also available through
http://w4.lns.cornell.edu/public/CLN
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