118 research outputs found
Converting capsules to sensors for nondestructive analysis:from cargo-responsive self-sensing to functional characterization
A general
concept of converting capsules into sensors is reported.
Such simple conversion enables instantaneous nondestructive analysis
for applications such as controlled release and energy storage among
others. Converted capsule sensors are responsive in emission colors
to varying core cargos via the incorporation of a solvatochromic fluorophore
under excitation. Such cargo-responsive self-sensing abilities facilitate
their application in capsule-level analysis such as cargo retention-leakage
detection and release implications, as well as defect identification.
The versatile concept is shown as an auxiliary tool in thermal energy
storage to visualize phase transition, exhibiting promising potentials
in application-level characterization
Highly luminescent gold nanoparticles: effect of ruthenium distance for nanoprobes with enhanced lifetimes
The photophysical properties of gold nanoparticles, AuNPs, with sizes of 13, 50 and 100 nm in diameter, coated with surface-active ruthenium complexes have been studied to investigate the effect of the distance of the ruthenium luminescent centre from the gold surface. Luminescence lifetimes of the three ruthenium probes, RuS1, RuS6 and RuS12, with different length spacer units between the surface active groups and the ruthenium centre were taken. The metal complexes were attached to AuNP13, AuNP50 and AuNP100via thiol groups using a method of precoating the nanoparticles with a fluorinated surfactant. The luminescence lifetime of the longer spacer unit complex, RuS12, was enhanced by 70% upon attachment to the AuNP when compared to the increase of the short and medium linker unit complexes, RuS1 (20%) and RuS6 (40%) respectively. The effect of the surfactant in the lifetime increase of the ruthenium coated AuNPs was shown to be larger for the medium spacer probe, RuS6. There was no effect of the change of the size of the AuNPs from 13 to 50 or 100 nm.</p
Chelating silica nanoparticles for efficient antibiotic delivery and particle imaging in Gram-negative bacteria
Polyethylene glycol assisted facile sol-gel synthesis of lanthanum oxide nanoparticles:structural characterisation and photoluminescence studies
Luminescence Lifetime-Based Sensing Platform Based on Cyclometalated Iridium(III) Complexes for the Detection of Perfluorooctanoic Acid in Aqueous Samples
Luminescence lifetimes are an attractive analytical method for detection due to its high sensitivity and stability. Iridium probes exhibit luminescence with long excited-state lifetimes, which are sensitive to the local environment. Perfluorooctanoic acid (PFOA) is listed as a chemical of high concern regarding its toxicity and is classified as a "forever chemical". In addition to strict limits on the presence of PFOA in drinking water, environmental contamination from industrial effluent or chemical spills requires rapid, simple, accurate, and cost-effective analysis in order to aid containment. Herein, we report the fabrication and function of a novel and facile luminescence sensor for PFOA based on iridium modified on gold surfaces. These surfaces were modified with lipophilic iridium complexes bearing alkyl chains, namely, IrC6 and IrC12, and Zonyl-FSA surfactant. Upon addition of PFOA, the modified surfaces IrC6-FSA@Au and IrC12-FSA @Au show the largest change in the red luminescence signal with changes in the luminescence lifetime that allow monitoring of PFOA concentrations in aqueous solutions. The platform was tested for the measurement of PFOA in aqueous samples spiked with known concentrations of PFOA and demonstrated the capacity to determine PFOA at concentrations >100 ΞΌg/L (240 nM).</p
Π‘ΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ ΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ ΠΊΠ°ΡΠ΅Π΄ΡΡ ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΈΠ±ΠΎΡΠΎΡΡΡΠΎΠ΅Π½ΠΈΡ Π’ΠΎΠΌΡΠΊΠΎΠ³ΠΎ ΠΏΠΎΠ»ΠΈΡΠ΅Ρ Π½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅ΡΠ° (55 Π»Π΅Ρ ΡΠΎ Π΄Π½Ρ ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΡ ΠΊΠ°ΡΠ΅Π΄ΡΡ)
Assisted delivery of anti-tumour platinum drugs using DNA-coiling gold nanoparticles bearing lumophores and intercalators:towards a new generation of multimodal nanocarriers with enhanced action
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Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich syndrome protein and ARP2/3 complex
The actin nodule is a novel F-actin structure present in platelets during early spreading. However, only limited detail is known regarding nodule organization and function. Here we use electron microscopy, SIM and dSTORM super-resolution, and live-cell TIRF microscopy to characterize the structural organization and signalling pathways associated with nodule formation. Nodules are composed of up to four actin-rich structures linked together by actin bundles. They are enriched in the adhesion-related proteins talin and vinculin, have a central core of tyrosine phosphorylated proteins and are depleted of integrins at the plasma membrane. Nodule formation is dependent on Wiskott-Aldrich syndrome protein (WASp) and the ARP2/3 complex. WASp(-/-) mouse blood displays impaired platelet aggregate formation at arteriolar shear rates. We propose actin nodules are platelet podosome-related structures required for platelet-platelet interaction and their absence contributes to the bleeding diathesis of Wiskott-Aldrich syndrome
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