Pityriasis rubra pilaris presenting with an abnormal autoimmune profile: two case reports

<p>Abstract</p> <p>Introduction</p> <p>Pityriasis rubra pilaris is an uncommon inflammatory and hyperproliferative dermatosis of juvenile or adult onset. The etiology of the disease is still unknown.</p> <p>Case presentation</p> <p>We present the cases of two Caucasian men aged 53 and 48 who presented with pityriasis rubra pillaris type 1; both patients also exhibited an abnormal immunological profile.</p> <p>Conclusion</p> <p>Pityriasis rubra pillaris is currently classified as a keratinization disorder. The abnormal immunological profile reported in our patients along with the comorbidity of pityriasis rubra pilaris with autoimmune disorders reported in the literature poses the question of a possible pathogenetic role for the immune response in this disorder.</p

Treatment of bromhidrosis with a glycine-soja sterocomplex topical product

Aims Bromhidrosis is a common problem with a severe negative impact on the patient’s social and emotional life. The objective of this open-label study was to evaluate the efficacy and safety of a local product with the main active ingredient of glycine-soja sterocomplex in the treatment of local bromhidrosis. Patients/methods Eighteen patients with axillary bromhidrosis and eight patients with bromhidrosis of the genital area were included. Bromhidrosis was evaluated through a sniff test of a worn garment on a four-point scale. Patients applied a glycine-soja sterocomplex topical agent twice daily on the affected areas for 15 days and bromhidrosis was evaluated again. Results Subjective mean level of bromhidrosis at baseline was 3.50 +/- 0.50 and after treatment 1.53 +/- 0.51. Mean impact on quality of life at baseline was 3.30 +/- 0.48 and after treatment 1.30 +/- 0.49. Investigators objective evaluation revealed an improvement in intensity of odor from 3.23 +/- 0.83 to 1.53 +/- 0.53 and in acceptability of odor from 3.1 +/- 1.01 to 1.65 +/- 0.76. Conclusions The glycine-soja sterocomplex topical agent shows encouraging improvement on both the intensity and quality of odor in patients with bromhidrosis and has a profound improvement on the patients’ quality of life without any side effects