Lycopene from two food sources does not affect antioxidant or cholesterol status of middle-aged adults

BACKGROUND: Epidemiological studies have reported associations between reduced cardiovascular disease and diets rich in tomato and/or lycopene. Intervention studies have shown that lycopene-containing foods may reduce cholesterol levels and lipid peroxidation, factors implicated in the initiation of cardiovascular disease. The objective of this study was to determine whether consumption of lycopene rich foods conferred cardiovascular protection to middle-aged adults as indicated by plasma lipid concentrations and measures of ex vivo antioxidants. METHODS: Ten healthy men and women consumed a low lycopene diet with no added lycopene (control treatment) or supplemented with watermelon or tomato juice each containing 20 mg lycopene. Subjects consumed each treatment for three weeks in a crossover design. Plasma, collected weekly was analyzed for total cholesterol, high density lipoprotein cholesterol (HDL-C) and triglyceride concentrations and for the antioxidant biomarkers of malondialdehyde formation products (MDA), plasma glutathione peroxidase (GPX) and ferric reducing ability of plasma (FRAP). Data were analyzed using Proc Mixed Procedure and associations between antioxidant and lipid measures were identified by Pearson's product moment correlation analysis. RESULTS: Compared to the control diet, the lycopene-containing foods did not affect plasma lipid concentrations or antioxidant biomarkers. Women had higher total cholesterol, HDL-C and triglyceride concentrations than did the men. Total cholesterol was positively correlated to MDA and FRAP while HDL-C was positively correlated to MDA and GPX. GPX was negatively correlated to triglyceride concentration. CONCLUSIONS: The inclusion of watermelon or tomato juice containing 20 mg lycopene did not affect plasma lipid concentrations or antioxidant status of healthy subjects. However, plasma cholesterol levels impacted the results of MDA and FRAP antioxidant tests

Flow Measurement by Means of Light Interference

There has been under development for the high-speed wind tunnel of the LFA an optical measuring arrangement for the qualitative and quantitative investigation of flow. By the use of interference measurements, the determination of density at the surface of the bodies being tested in the air stream and in the vicinity of these bodies can be undertaken. The results obtained so far in the simple preliminary investigations show that it is possible, even at a low Reynolds number, to obtain the density field in the neighborhood of a test body by optical means. Simple analytical expressions give the relation between density, pressure, velocity, and temperature. In addition to this, the interference measurement furnishes valuable data on the state of the boundary layer, that is, the sort of boundary layer (whether laminar or turbulent), as well as the temperature and velocity distribution

Development and Construction of an Interferometer for Optical Measurements of Density Fields

A method of interference is described in the present report which promises profitable application in aeronautical research. The physical foundation of the method and a simple method of adjustment are briefly discussed. The special technical construction of the instrument is described which guarantees its use also in the case of vibrations of the surrounding space and permits the investigation of unsteady phenomena. It is found that the interference method will make the small differences in density in the flow field around the body even at low speeds. (40 m/sec) optically measurable

Development and construction of an interferometer for measuring density fields by optical means

In the following report an interference procedure is described which promises a useful application in aeronautical research. The physical basis of the procedure and a simple method of adjustment are explained. Further a special technical design of the apparatus is described, insuring its usability even where shocks are present in the area, and permitting the study of non-steady phenomena. The possibility is established of measuring optically the small density variations surrounding bodies in a flow even at low speeds (40 metre per sec.), using the interference procedure.Peer reviewed: NoNRC publication: Ye

Structure determination of molecular nanocomposites by combining pair distribution function analysis and solid-state NMR

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