Spline analyses for the relationship between serum phosphorus and risk of incident dementia with serum phosphorus probability distribution histogram represented in gray bars in the background.

<p>Fig 2a: Overall cohort. Fig 2b: Analysis was restricted to cohort participants with serum phosphorus level >2.5 mg/dl. Fig 2c: Analysis was restricted to cohort participants with serum phosphorus level >4.5 mg/dl.</p

Demographic and clinical characteristics according to renal function trajectory.

<p>Demographic and clinical characteristics according to renal function trajectory.</p

Adjusted associations of improved eGFR slope, and declining eGFR slopes.

<p>Model adjusted for age, race, gender, diabetes mellitus, hypertension, cardiovascular disease, hyperlipidemia, peripheral artery disease, cerebrovascular disease, chronic lung disease, hepatitis C, HIV, dementia, and initial eGFR. Reference group is patients with stable eGFR slope.</p

Cohort design and timeline.

<p>Cohort design and timeline.</p

Flow chart for cohort selection.

<p>Flow chart for cohort selection.</p

Renal function trajectory phenotypes.

<p>Renal function trajectory phenotypes.</p

Baseline demographic and health characteristics of cohort participants.

Baseline demographic and health characteristics of cohort participants.</p

Relationship between serum phosphorus (in quintiles) and risk of incident dementia.

Relationship between serum phosphorus (in quintiles) and risk of incident dementia.</p

Change in kidney function and the risk of death.

<p>Model 1 adjusted for age, race, gender, diabetes mellitus, hypertension, cardiovascular disease, hyperlipidemia, peripheral artery disease, cerebrovascular disease, chronic lung disease, hepatitis C, HIV, dementia and eGFR at time of cohort entry (T0). Reference group is patients with stable kidney function (eGFR slope).</p

Adjusted associations of trajectory phenotypes.

HIFNT = High Intercept and Fast Negative Trajectory includes trajectory F. HIPT = High Intercept Positive Trajectory and includes trajectory A and B; IIMNT = Intermediate Intercept Mild Negative Trajectory and includes trajectory C, and D; LIFNT = Low Intercept Fast Negative Trajectory and includes trajectory E and G; Model adjusted for age, race, gender, for age, race, gender, diabetes mellitus, hypertension, cardiovascular disease, hyperlipidemia, peripheral artery disease, cerebrovascular disease, chronic lung disease, hepatitis C, HIV, dementia, and eGFR at time of cohort entry (T0). Reference group is IIMNT.</p