106 research outputs found
The Ought-to-be and to-be of the Construction of Social Psychological Service System: Based on the Evaluation of 12 Pilot Areas in China
The construction of social psychological service system is an important measure to innovate social governance in China, which aims to solve the problems of social mentality cultivation and psychological construction. However, whether the âmeaning of oughtnessâ of this concept can be implemented in the construction practice all over the country remains to be discussed. This study collected the network text data of the actual work situation in 12 pilot areas of social psychological service system construction in China, and coded the data according to 6 primary indicators such as organizational structure and work mode and 23 secondary indicators under them to describe the âactual situationâ of construction in various places. The text analysis results show that: (1) the content orientation of the construction of social psychological service system in each pilot area has a serious tendency of âmental healthâ; (2) on the whole, psychosocial services only focus on ârisk prevention and controlâ; (3) the relationship between social psychological service and social governance is misplaced. In short, there is a big gap between the âactual situationâ and âmeaning of oughtnessâ of the construction of social psychological service system all over the country
Survival of AIDS Patients Treated with Traditional Chinese Medicine in Rural Central China: A Retrospective Cohort Study, 2004â2012
This study aimed to explore the survival of AIDS patients treated with traditional Chinese medicine (TCM) in addition to combined antiretroviral therapy (cART) and of AIDS patients treated with cART. Data of patients taking cART between 30 October 2003 and 30 October 2004 in the National TCM HIV Treatment Trial Program area were retrospectively analyzed, with follow-up from 30 October 2004 to 30 October 2012. The log-rank test was used to compare survival between the two groups. A Cox proportional hazards model was used to determine hazard ratios to identify prognostic factors. The study included 521 patients in the TCM + cART group followed up for 3548 person-years and 375 patients in the cART group followed up for 2523 person-years. Mortality rates were 3.2/100 person-years and 4.2/100 person-years in the TCM + cART and cART groups, respectively. The difference in survival was significant. After adjusting for explanatory variables, the mortality rate of AIDS patients in the cART group was 1.7 times higher than in the TCM + cART group. Male sex, older age, little education, and lower CD4 cell count were risk factors for mortality. TCM intervention in addition to cART could increase survival of AIDS patients
Negative flat band magnetism in a spin-orbit coupled correlated kagome magnet
It has long been speculated that electronic flat band systems can be a
fertile ground for hosting novel emergent phenomena including unconventional
magnetism and superconductivity. Although flat bands are known to exist in a
few systems such as heavy fermion materials and twisted bilayer graphene, their
microscopic roles and underlying mechanisms in generating emergent behavior
remain elusive. Here we use scanning tunneling microscopy to elucidate the
atomically resolved electronic states and their magnetic response in the kagome
magnet Co3Sn2S2. We observe a pronounced peak at the Fermi level, which is
identified to arise from the kinetically frustrated kagome flat band.
Increasing magnetic field up to +-8T, this state exhibits an anomalous
magnetization-polarized Zeeman shift, dominated by an orbital moment in
opposite to the field direction. Such negative magnetism can be understood as
spin-orbit coupling induced quantum phase effects tied to non-trivial flat band
systems. We image the flat band peak, resolve the associated negative
magnetism, and provide its connection to the Berry curvature field, showing
that Co3Sn2S2 is a rare example of kagome magnet where the low energy physics
can be dominated by the spin-orbit coupled flat band. Our methodology of
probing band-resolved ordering phenomena such as spin-orbit magnetism can also
be applied in future experiments to elucidate other exotic phenomena including
flat band superconductivity and anomalous quantum transport.Comment: Nature Physics onlin
Survival outcomes of stage I colorectal cancer:development and validation of the ACEPLY model using two prospective cohorts
BACKGROUND: Approximately 10% of stage I colorectal cancer (CRC) patients experience unfavorable clinical outcomes after surgery. However, little is known about the subset of stage I patients who are predisposed to high risk of recurrence or death. Previous evidence was limited by small sample sizes and lack of validation. METHODS: We aimed to identify early indicators and develop a risk stratification model to inform prognosis of stage I patients by employing two large prospective cohorts. Prognostic factors for stage II tumors, including T stage, number of nodes examined, preoperative carcinoma embryonic antigen (CEA), lymphovascular invasion, perineural invasion (PNI), and tumor grade were investigated in the discovery cohort, and significant findings were further validated in the other cohort. We adopted disease-free survival (DFS) as the primary outcome for maximum statistical power and recurrence rate and overall survival (OS) as secondary outcomes. Hazard ratios (HRs) were estimated from Cox proportional hazard models, which were subsequently utilized to develop a multivariable model to predict DFS. Predictive performance was assessed in relation to discrimination, calibration and net benefit. RESULTS: A total of 728 and 413 patients were included for discovery and validation. Overall, 6.7% and 4.1% of the patients developed recurrences during follow-up. We identified consistent significant effects of PNI and higher preoperative CEA on inferior DFS in both the discovery (PNI: HRâ=â4.26, 95% CI: 1.70â10.67, pâ=â0.002; CEA: HRâ=â1.46, 95% CI: 1.13â1.87, pâ=â0.003) and the validation analysis (PNI: HRâ=â3.31, 95% CI: 1.01â10.89, pâ=â0.049; CEA: HRâ=â1.58, 95% CI: 1.10â2.28, pâ=â0.014). They were also significantly associated with recurrence rate. Age at diagnosis was a prominent determinant of OS. A prediction model on DFS using Age at diagnosis, CEA, PNI, and number of LYmph nodes examined (ACEPLY) showed significant discriminative performance (C-index: 0.69, 95% CI:0.60â0.77) in the external validation cohort. Decision curve analysis demonstrated added clinical benefit of applying the model for risk stratification. CONCLUSIONS: PNI and preoperative CEA are useful indicators for inferior survival outcomes of stage I CRC. Identification of stage I patients at high risk of recurrence is feasible using the ACEPLY model, although the predictive performance is yet to be improved. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12916-022-02693-7
Superconductivity and orbital-selective nematic order in a new titanium-based kagome metal CsTi3Bi5
Fabrication of new types of superconductors with novel physical properties
has always been a major thread in the research of superconducting materials. An
example is the enormous interests generated by the cascade of correlated
topological quantum states in the newly discovered vanadium-based kagome
superconductors AV3Sb5 (A=K, Rb, and Cs) with a Z2 topological band structure.
Here we report the successful fabrication of single-crystals of titanium-based
kagome metal CsTi3Bi5 and the observation of superconductivity and electronic
nematicity. The onset of the superconducting transition temperature Tc is
around 4.8 K. In sharp contrast to the charge density wave superconductor
AV3Sb5, we find that the kagome superconductor CsTi3Bi5 preserves translation
symmetry, but breaks rotational symmetry and exhibits an electronic nematicity.
The angular-dependent magnetoresistivity shows a remarkable two-fold rotational
symmetry as the magnetic field rotates in the kagome plane. The scanning
tunneling microscopy and spectroscopic imaging detect rotational-symmetry
breaking C2 quasiparticle interference patterns (QPI) at low energies,
providing further microscopic evidence for electronic nematicity. Combined with
first-principle calculations, we find that the nematic QPI is orbital-selective
and dominated by the Ti dxz and dyz orbitals, possibly originating from the
intriguing orbital bond nematic order. Our findings in the new "135" material
CsTi3Bi5 provide new directions for exploring the multi-orbital correlation
effect and the role of orbital or bond order in the electron liquid crystal
phases evidenced by the symmetry breaking states in kagome superconductors
Up-regulation of bone marrow stromal protein 2 (BST2) in breast cancer with bone metastasis
<p>Abstract</p> <p>Background</p> <p>Bone metastases are frequent complications of breast cancer. Recent literature implicates multiple chemokines in the formation of bone metastases in breast cancer. However, the molecular mechanism of metastatic bone disease in breast cancer remains unknown. We have recently made the novel observation of the BST2 protein expression in human breast cancer cell lines. The purpose of our present study is to investigate the expression and the role of BST2 in bone metastatic breast cancer.</p> <p>Methods</p> <p>cDNA microarray analysis was used to compare the BST2 gene expression between a metastatic to bone human breast cancer cell line (MDA-231BO) and a primary human breast cancer cell line (MDA-231). The BST2 expression in one bone metastatic breast cancer and seven non-bone metastatic breast cancer cell lines were also determined using real-time RT-PCR and Western blot assays. We then employed tissue array to further study the BST2 expression in human breast cancer using array slides containing 20 independent breast cancer tumors that formed metastatic bone lesions, 30 non-metastasis-forming breast cancer tumors, and 8 normal breast tissues. In order to test the feasibility of utilizing BST2 as a serum marker for the presence of bone metastasis in breast cancer, we had measured the BST2 expression levels in human serums by using ELISA on 43 breast cancer patients with bone metastasis, 43 breast cancer patients without bone metastasis, and 14 normal healthy controls. The relationship between cell migration and proliferation and BST2 expression was also studied in a human breast recombinant model system using migration and FACS analysis.</p> <p>Results</p> <p>The microarray demonstrated over expression of the BST2 gene in the bone metastatic breast cancer cell line (MDA-231BO) compared to the primary human breast cancer cell line (MDA-231). The expression of the BST2 gene was significantly increased in the bone metastatic breast cancer cell lines and tumor tissues compared to non-bone metastatic breast cancer cell lines and tumor tissues by real time RT-PCR, Western blot and TMA. Furthermore, serum levels of BST2 measured by ELISA were also significantly higher among patients with breast cancer metastatic to bone compared to breast cancer patients without metastatic to bone (P < .0001). Most importantly, the breast cancer cell line that transfected with BST2 demonstrated increased BST2 expressions, which was associated with increased cancer cell migration and cell proliferation.</p> <p>Conclusion</p> <p>These results provide novel data indicating the BST2 protein expression is associated with the formation of bone metastases in human breast cancer. We believe that BST2 may be a potential biomarker in breast cancer with bone metastasis.</p
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