The Ought-to-be and to-be of the Construction of Social Psychological Service System: Based on the Evaluation of 12 Pilot Areas in China

The construction of social psychological service system is an important measure to innovate social governance in China, which aims to solve the problems of social mentality cultivation and psychological construction. However, whether the “meaning of oughtness” of this concept can be implemented in the construction practice all over the country remains to be discussed. This study collected the network text data of the actual work situation in 12 pilot areas of social psychological service system construction in China, and coded the data according to 6 primary indicators such as organizational structure and work mode and 23 secondary indicators under them to describe the “actual situation” of construction in various places. The text analysis results show that: (1) the content orientation of the construction of social psychological service system in each pilot area has a serious tendency of “mental health”; (2) on the whole, psychosocial services only focus on “risk prevention and control”; (3) the relationship between social psychological service and social governance is misplaced. In short, there is a big gap between the “actual situation” and “meaning of oughtness” of the construction of social psychological service system all over the country

Business culture impairs facial trustworthiness judgments

Previous research has found that business culture has a detrimental impact on interpersonal trust. To understand whether this impact extends to rapid, automatic, bottom–up judgments of facial trustworthiness, we conducted 4 experiments involving 244 participants from economic and non-economic backgrounds. We presented participants with both trustworthy and untrustworthy faces and asked them to make judgments on trustworthiness. The results show that individuals who are engaged in studying economics, work in an economics-related occupation, or are exposed to an imagined business culture evaluate trustworthy faces to be less trustworthy. The findings shed light on why and how business culture affects the formation of interpersonal trust

Survival of AIDS Patients Treated with Traditional Chinese Medicine in Rural Central China: A Retrospective Cohort Study, 2004–2012

This study aimed to explore the survival of AIDS patients treated with traditional Chinese medicine (TCM) in addition to combined antiretroviral therapy (cART) and of AIDS patients treated with cART. Data of patients taking cART between 30 October 2003 and 30 October 2004 in the National TCM HIV Treatment Trial Program area were retrospectively analyzed, with follow-up from 30 October 2004 to 30 October 2012. The log-rank test was used to compare survival between the two groups. A Cox proportional hazards model was used to determine hazard ratios to identify prognostic factors. The study included 521 patients in the TCM + cART group followed up for 3548 person-years and 375 patients in the cART group followed up for 2523 person-years. Mortality rates were 3.2/100 person-years and 4.2/100 person-years in the TCM + cART and cART groups, respectively. The difference in survival was significant. After adjusting for explanatory variables, the mortality rate of AIDS patients in the cART group was 1.7 times higher than in the TCM + cART group. Male sex, older age, little education, and lower CD4 cell count were risk factors for mortality. TCM intervention in addition to cART could increase survival of AIDS patients

Closed-Loop Unsupervised Representation Disentanglement with β\beta-VAE Distillation and Diffusion Probabilistic Feedback

Representation disentanglement may help AI fundamentally understand the real world and thus benefit both discrimination and generation tasks. It currently has at least three unresolved core issues: (i) heavy reliance on label annotation and synthetic data -- causing poor generalization on natural scenarios; (ii) heuristic/hand-craft disentangling constraints make it hard to adaptively achieve an optimal training trade-off; (iii) lacking reasonable evaluation metric, especially for the real label-free data. To address these challenges, we propose a \textbf{C}losed-\textbf{L}oop unsupervised representation \textbf{Dis}entanglement approach dubbed \textbf{CL-Dis}. Specifically, we use diffusion-based autoencoder (Diff-AE) as a backbone while resorting to $\beta$-VAE as a co-pilot to extract semantically disentangled representations. The strong generation ability of diffusion model and the good disentanglement ability of VAE model are complementary. To strengthen disentangling, VAE-latent distillation and diffusion-wise feedback are interconnected in a closed-loop system for a further mutual promotion. Then, a self-supervised \textbf{Navigation} strategy is introduced to identify interpretable semantic directions in the disentangled latent space. Finally, a new metric based on content tracking is designed to evaluate the disentanglement effect. Experiments demonstrate the superiority of CL-Dis on applications like real image manipulation and visual analysis

Negative flat band magnetism in a spin-orbit coupled correlated kagome magnet

It has long been speculated that electronic flat band systems can be a fertile ground for hosting novel emergent phenomena including unconventional magnetism and superconductivity. Although flat bands are known to exist in a few systems such as heavy fermion materials and twisted bilayer graphene, their microscopic roles and underlying mechanisms in generating emergent behavior remain elusive. Here we use scanning tunneling microscopy to elucidate the atomically resolved electronic states and their magnetic response in the kagome magnet Co3Sn2S2. We observe a pronounced peak at the Fermi level, which is identified to arise from the kinetically frustrated kagome flat band. Increasing magnetic field up to +-8T, this state exhibits an anomalous magnetization-polarized Zeeman shift, dominated by an orbital moment in opposite to the field direction. Such negative magnetism can be understood as spin-orbit coupling induced quantum phase effects tied to non-trivial flat band systems. We image the flat band peak, resolve the associated negative magnetism, and provide its connection to the Berry curvature field, showing that Co3Sn2S2 is a rare example of kagome magnet where the low energy physics can be dominated by the spin-orbit coupled flat band. Our methodology of probing band-resolved ordering phenomena such as spin-orbit magnetism can also be applied in future experiments to elucidate other exotic phenomena including flat band superconductivity and anomalous quantum transport.Comment: Nature Physics onlin

Survival outcomes of stage I colorectal cancer:development and validation of the ACEPLY model using two prospective cohorts

BACKGROUND: Approximately 10% of stage I colorectal cancer (CRC) patients experience unfavorable clinical outcomes after surgery. However, little is known about the subset of stage I patients who are predisposed to high risk of recurrence or death. Previous evidence was limited by small sample sizes and lack of validation. METHODS: We aimed to identify early indicators and develop a risk stratification model to inform prognosis of stage I patients by employing two large prospective cohorts. Prognostic factors for stage II tumors, including T stage, number of nodes examined, preoperative carcinoma embryonic antigen (CEA), lymphovascular invasion, perineural invasion (PNI), and tumor grade were investigated in the discovery cohort, and significant findings were further validated in the other cohort. We adopted disease-free survival (DFS) as the primary outcome for maximum statistical power and recurrence rate and overall survival (OS) as secondary outcomes. Hazard ratios (HRs) were estimated from Cox proportional hazard models, which were subsequently utilized to develop a multivariable model to predict DFS. Predictive performance was assessed in relation to discrimination, calibration and net benefit. RESULTS: A total of 728 and 413 patients were included for discovery and validation. Overall, 6.7% and 4.1% of the patients developed recurrences during follow-up. We identified consistent significant effects of PNI and higher preoperative CEA on inferior DFS in both the discovery (PNI: HR = 4.26, 95% CI: 1.70–10.67, p = 0.002; CEA: HR = 1.46, 95% CI: 1.13–1.87, p = 0.003) and the validation analysis (PNI: HR = 3.31, 95% CI: 1.01–10.89, p = 0.049; CEA: HR = 1.58, 95% CI: 1.10–2.28, p = 0.014). They were also significantly associated with recurrence rate. Age at diagnosis was a prominent determinant of OS. A prediction model on DFS using Age at diagnosis, CEA, PNI, and number of LYmph nodes examined (ACEPLY) showed significant discriminative performance (C-index: 0.69, 95% CI:0.60–0.77) in the external validation cohort. Decision curve analysis demonstrated added clinical benefit of applying the model for risk stratification. CONCLUSIONS: PNI and preoperative CEA are useful indicators for inferior survival outcomes of stage I CRC. Identification of stage I patients at high risk of recurrence is feasible using the ACEPLY model, although the predictive performance is yet to be improved. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12916-022-02693-7