Transition from subbarrier to deep subbarrier regimes in heavy-ion fusion reactions

We analyze the recent experimental data of heavy-ion fusion cross sections available up to deep subbarrier energies in order to discuss the threshold incident energy for a deep subbarrier fusion hindrance phenomenon. To this end, we employ a one-dimensional potential model with a Woods-Saxon internuclear potential. Fitting the experimental data in two different energy regions with different Woods-Saxon potentials, we define the threshold energy as an intersect of the two fusion excitation functions. We show that the threshold energies so extracted are in good agreement with the empirical systematics as well as with the values of the Krappe-Nix-Sierk (KNS) potential at the touching point. We also discuss the asymptotic energy shift of fusion cross sections with respect to the potential model calculations, and show that it decreases with decreasing energies in the deep subbarrier region although it takes a constant value at subbarrier energies.Comment: 4 pages, 4 figure

Algorithm for Fault Location and Classification on Parallel Transmission Line using Wavelet based on Clarke’s Transformation

This paper proposed a new algorithm for fault location and classification using wavelet based on Clarke’s transformation to obtain the fault current. This novel method of fault current approach is studied by comparing the use of the glide path of the fault voltage. The current alpha and beta (Current Mode) were used to transform the signal using discrete wavelet transform (DWT). The fault location was determined by using the Clarke’s transformation, and then turned into a wavelet, which was very precise and thorough. The most accurate was the mother wavelet Db4 which had the fastest time and smallest error detection when compared with the other wavelet mothers. In this study, the Clarke’s transformation is also compared with the Karenbauer’s, which has produced results with similar error percentage. The simulation results using PSCAD / EMTDC software showed that the proposed algorithm could distinguish internal and external faults to get the current signal in the transformation of a signal fault

Quasilocal energy for rotating charged black hole solutions in general relativity and string theory

We explore the (non)-universality of Martinez's conjecture, originally proposed for Kerr black holes, within and beyond general relativity. The conjecture states that the Brown-York quasilocal energy at the outer horizon of such a black hole reduces to twice its irreducible mass, or equivalently, to \sqrt{A} /(2\sqrt{pi}), where `A' is its area. We first consider the charged Kerr black hole. For such a spacetime, we calculate the quasilocal energy within a two-surface of constant Boyer-Lindquist radius embedded in a constant stationary-time slice. Keeping with Martinez's conjecture, at the outer horizon this energy equals the irreducible mass. The energy is positive and monotonically decreases to the ADM mass as the boundary-surface radius diverges. Next we perform an analogous calculation for the quasilocal energy for the Kerr-Sen spacetime, which corresponds to four-dimensional rotating charged black hole solutions in heterotic string theory. The behavior of this energy as a function of the boundary-surface radius is similar to the charged Kerr case. However, we show that in this case it does not approach the expression conjectured by Martinez at the horizon.Comment: 15 page

Radiopharmaceutical Validation for Clinical Use

Radiopharmaceuticals are reemerging as attractive anticancer agents, but there are no universally adopted guidelines or standardized procedures for evaluating agent validity before early-phase trial implementation. To validate a radiopharmaceutical, it is desirous for the radiopharmaceutical to be specific, selective, and deliverable against tumors of a given, molecularly defined cancer for which it is intended to treat. In this article, we discuss four levels of evidence—target antigen immunohistochemistry, in vitro and in vivo preclinical experiments, animal biodistribution and dosimetry studies, and first-in-human microdose biodistribution studies—that might be used to justify oncology therapeutic radiopharmaceuticals in a drug-development sequence involving early-phase trials. We discuss common practices for validating radiopharmaceuticals for clinical use, everyday pitfalls, and commonplace operationalizing steps for radiopharmaceutical early-phase trials. We anticipate in the near-term that radiopharmaceutical trials will become a larger proportion of the National Cancer Institute Cancer Therapy Evaluation Program (CTEP) portfolio

Understanding the mechanisms of lung mechanical stress

Physical forces affect both the function and phenotype of cells in the lung. Bronchial, alveolar, and other parenchymal cells, as well as fibroblasts and macrophages, are normally subjected to a variety of passive and active mechanical forces associated with lung inflation and vascular perfusion as a result of the dynamic nature of lung function. These forces include changes in stress (force per unit area) or strain (any forced change in length in relation to the initial length) and shear stress (the stress component parallel to a given surface). The responses of cells to mechanical forces are the result of the cell's ability to sense and transduce these stimuli into intracellular signaling pathways able to communicate the information to its interior. This review will focus on the modulation of intracellular pathways by lung mechanical forces and the intercellular signaling. A better understanding of the mechanisms by which lung cells transduce physical forces into biochemical and biological signals is of key importance for identifying targets for the treatment and prevention of physical force-related disorders

Capecitabine and Temozolomide in Neuroendocrine Tumor of Unknown Primary

Incidence of low grade well-differentiated neuroendocrine tumors (NET) is on the rise. The North American Neuroendocrine Tumor Society estimates that the United States has more than 150,000 gastroenteropancreatic NET patients. About 10% of metastatic NETs can be unknown primary, and due to their rarity, dedicated treatment algorithms and regimens are not defined. Combination of capecitabine and temozolomide (CAPTEM) is one of the systemic treatments used in gastroenteropancreatic NETs. We explored clinical activity of CAPTEM in NET of unknown primary. Methods. Retrospective review of NET of unknown primary managed at the University of Kentucky over the past five years (2012–2016). Result. 56 patients with NET of unknown primary were identified; 12 patients were treated with CAPTEM. Median progression-free survival on CAPTEM in grade II and grade III NET of unknown primary was 10.8 and 7 months, respectively. Six patients showed reduction in metastatic tumor volume at three-month CT scan. Three patients had stable disease and three patients showed disease progression at the first surveillance scan. Common side-effects were as follows: four patients developed grade II thrombocytopenia, three patients developed grade I lymphocytopenia, and two patients developed hand foot syndrome (grades I and III). Six patients developed grade I fatigue. Conclusion. CAPTEM should be considered for grades I and II NET of unknown primary, especially in the case of visceral crisis or bulky disease

Elastic scattering losses in the four-wave mixing of Bose Einstein Condensates

We introduce a classical stochastic field method that accounts for the quantum fluctuations responsible for spontaneous initiation of various atom optics processes. We assume a delta-correlated Gaussian noise in all initially empty modes of atomic field. Its strength is determined by comparison with the analytical results for two colliding condensates in the low loss limit. Our method is applied to the atomic four wave mixing experiment performed at MIT [Vogels {\it et. al.}, Phys. Rev. Lett. {\bf 89}, 020401, (2002)], for the first time reproducing experimental data

Comparative study of back-stepping controller and super twisting sliding mode controller for indirect power control of wind generator

© 2021 Springer. This is the accepted manuscript version of an article which has been published in final form at https://doi.org/10.1007/s13198-019-00905-7This paper presents the application nonlinear control to regulate the rotor currents and control the active and reactive powers generated by the Doubly Fed Induction Generator used in the Wind Energy Conversion System (WECS). The proposed control strategies are based on Lyapunov stability theory and include back-stepping control (BSC) and super-twisting sliding mode control. The overall WECS model and control scheme are developed in MATLAB/Simulink and the simulation results have shown that the BSC leads to superior performance and improved transient response as compared to the STSMC controller.Peer reviewe

First report of brown widow spider sightings in Peninsular Malaysia and notes on its global distribution

Background The brown widow spider (Latrodectus geometricus Koch, 1841) has colonised many parts of the world from its continent of origin, Africa. By at least 1841, the species had successfully established populations in South America and has more recently expanded its range to the southern states of North America. This highly adaptable spider has been far more successful in finding its niche around the world than its famous cousins, the black widow, Latrodectus mactans, found in the south-eastern states of North America, and the red-back, Latrodectus hasselti, found mostly in Australia, New Zealand and Japan. Methods We performed an extensive web search of brown widow sightings and mapped the location of each sighting using ArcGIS. Specimens reputedly of the species L. geometricus were collected at three localities in Peninsular Malaysia. The spiders were identified and documented based on an examination of morphological characteristics and DNA barcoding. Results The spiders found in Peninsular Malaysia were confirmed to be Latrodectus geometricus based on their morphological characteristics and DNA barcodes. We recorded 354 sightings of the brown widow in 58 countries, including Peninsular Malaysia. Conclusion Reports from the Americas and the Far East suggest a global-wide invasion of the brown widow spider. Herein we report the arrival of the brown widow spider in Peninsular Malaysia and provide notes on the identification of the species and its recently expanded range