Sex-Specific Phenotypic Plasticity as a Complex Reaction of Human Organism to Different Environmental Conditions

Complex anthropological investigations of modern students were carried out in the three big cities of the Russian Federation (Samara, Arkhangelsk, Saransk), as well as in the villages of Mordovia. The program of morphofunctional investigation included body characteristics, body mass components (evaluated with the bioelectrical impedance analyzer “Medass-1”), physiological characteristics of cardiovascular and respiratory systems, right hand grip strength (dynamometry). To evaluate the level of sexual dimorphism, coefficient of sexual dimorphism (CSD) was used in this study. The total number of the studied subjects was 476 young women and 375 young men, from 17 to 23 years old. The results of ANOVA analyses show the presence of non-random variations for the majority of studied characteristics in the examined groups. On this basis, it is possible to consider that different environmental conditions exert significant influence on human organism, which is the core of the adaptation process. The largest distance separates the groups from the city of Saransk and Mordovian villages. It shows that the impact of social and environmental factors for rural and urban inhabitants is much larger as compared to ecological ones, e.g., latitude of the location. Comparison of the CSD values in all groups showed that the degree of adaptation potentials is considerably different in males and females for many characteristics. Thus, for body mass components, characteristics of respiratory system, height and BMI, males are more sensitive to environmental influences. For the cardiovascular system traits, the degree of fat tissue development and body mass, the strength of adaptation changes is practically equal in men and women, with slight advantages in men

Model-Based Analysis of Changes in the Morphological Characteristics of Moscow Students for the Last Two Decades

The aim of the paper is to develop a model of changes in morphological characteristics of young males and females body structure at the beginning of the 21st century. For this purpose the results of Moscow students’ annual screenings from 2000 to 2018 were analyzed (total number of 17–18-year-olds − 6,433 individuals). As a result, five factors describing the trends of changes were revealed and further analysis demonstrated variants of their values over time. An original model was developed, which reflected real morphological transformations in the body parameters of the young generation for the last 20 years. For both sex groups a trend towards macrosomia (gr. macros − big, soma- body) was revealed. For the boys some increase in linear traits was found with a decrease in muscularity. In girls, parabolic association between athletic characteristics and the year of investigation was found: the decrease in muscularity for the first decade, and its increase for the second one

Место современных продуктов прикорма в критическом периоде формирования здоровья ребенка

The current development of medicine and the results of recent large-scale academic research in pediatrics provide the convincing conclusions that the formation of human health begins in the antenatal period of ontogenesis and continues throughout the infancy. The ideas and subsequent academic research on the influence of nutrition during the first thousand days of life on the programming of metabolism and the development of some chronic somatic diseases such as obesity, hypertension, coronary heart disease have become widespread. In addition, at the same period of life immune abnormalities with a predominance of one of the subpopulations, Th1 or Th2, can possibly form in children at risk of developing allergies when immune response is developing. The predominance of the Th2 cytokine profile (hyperproduction of interleukins 4, 5, 13, etc.) suggests the possibility of stable formation of the atopic status in a child afterwards. Consequently, the application of academic knowledge on the health status programming by nutrition during early ontogenesis is an important tool in preventive pediatric practice.Развитие современной медицины, результаты последних масштабных научных исследований в педиатрии приводят к убедительным выводам, что формирование здоровья человека начинается в антенатальном периоде онтогенеза и продолжается на протяжении раннего детского возраста. Широкое распространение получили идеи и последовавшие за ними научные исследования о влиянии питания первых тысячи дней жизни в программировании метаболизма и развитии некоторых хронических соматических болезней, таких как ожирение, гипертоническая болезнь, ишемическая болезнь сердца. Вместе с тем в этот же период жизни у детей групп риска по развитию аллергии при становлении иммунного ответа возможно программирование иммунных отклонений с преобладанием одной из субпопуляций — Th1 или Th2. Преобладание цитокинового профиля Th2 (гиперпродукция интерлейкинов 4, 5, 13 и др.) предполагает возможность стойкого формирования атопического статуса ребенка в дальнейшем. Следовательно, использование научных знаний о программировании состояния здоровья питанием в процессе раннего онтогенеза является важным инструментом в практической профилактической педиатрии.КОНФЛИКТ ИНТЕРЕСОВТ.В. Турти, Е.Г. Бокучава сотрудничают с АО «ПРОГРЕСС».И.А. Беляева сотрудничает с компанией «Пфайзер Инновации».Остальные авторы статьи подтвердили отсутствие конфликта интересов

Sex-Specific Phenotypic Plasticity as a Complex Reaction of Human Organism to Different Environmental Conditions

Complex anthropological investigations of modern students were carried out in the three big cities of the Russian Federation (Samara, Arkhangelsk, Saransk), as well as in the villages of Mordovia. The program of morphofunctional investigation included body characteristics, body mass components (evaluated with the bioelectrical impedance analyzer “Medass-1”), physiological characteristics of cardiovascular and respiratory systems, right hand grip strength (dynamometry). To evaluate the level of sexual dimorphism, coefficient of sexual dimorphism (CSD) was used in this study. The total number of the studied subjects was 476 young women and 375 young men, from 17 to 23 years old. The results of ANOVA analyses show the presence of non-random variations for the majority of studied characteristics in the examined groups. On this basis, it is possible to consider that different environmental conditions exert significant influence on human organism, which is the core of the adaptation process. The largest distance separates the groups from the city of Saransk and Mordovian villages. It shows that the impact of social and environmental factors for rural and urban inhabitants is much larger as compared to ecological ones, e.g., latitude of the location. Comparison of the CSD values in all groups showed that the degree of adaptation potentials is considerably different in males and females for many characteristics. Thus, for body mass components, characteristics of respiratory system, height and BMI, males are more sensitive to environmental influences. For the cardiovascular system traits, the degree of fat tissue development and body mass, the strength of adaptation changes is practically equal in men and women, with slight advantages in men

Implication of Modern Complementary Foods in Critical Period for Child Health Programming

The current development of medicine and the results of recent large-scale academic research in pediatrics provide the convincing conclusions that the formation of human health begins in the antenatal period of ontogenesis and continues throughout the infancy. The ideas and subsequent academic research on the influence of nutrition during the first thousand days of life on the programming of metabolism and the development of some chronic somatic diseases such as obesity, hypertension, coronary heart disease have become widespread. In addition, at the same period of life immune abnormalities with a predominance of one of the subpopulations, Th1 or Th2, can possibly form in children at risk of developing allergies when immune response is developing. The predominance of the Th2 cytokine profile (hyperproduction of interleukins 4, 5, 13, etc.) suggests the possibility of stable formation of the atopic status in a child afterwards. Consequently, the application of academic knowledge on the health status programming by nutrition during early ontogenesis is an important tool in preventive pediatric practice