Transcatheter arterial chemoembolization combined with apatinib and camrelizumab for unresectable advanced gastric or gastroesophageal junction cancer: a single-arm, single-center, retrospective study

PurposeThis study aims to investigate the efficacy and safety of transcatheter arterial chemoembolization (TACE) combined with Apatinib and Camrelizumab for treating unresectable advanced gastric or gastroesophageal junction (G/GEJ) cancer.Material and methodsIn this study, data of patients with unresectable advanced G/GEJ cancer who received TACE combined with Apatinib and Camrelizumab from August 2018 to December 2021 was evaluated. After TACE, patients were given intravenous Camrelizumab 200mg every three weeks and oral apatinib 250mg/day for treatment. The primary endpoint was overall survival (OS), and the secondary endpoints were objective response rate (ORR), disease control rate (DCR), and adverse events (AEs).ResultsA total of 49 patients were enrolled in this study. The median follow-up time was 14.0 months, and the median OS was 20.0 months (95% CI = 13.6-26.4). Two patients (4.08%) achieved complete remission, 28 patients (57.14%) achieved partial remission, 18 patients (36.73%) had stable disease, and 1 patient (2.04%) had disease progression. The ORR was 61.22%, and the DCR was 97.96%. Multivariate Cox regression analysis indicated that age (HR 4.74, 95% CI = 1.674-13.440, P=0.003) and multiple distant metastases (HR 20.916, 95% CI = 4.094-106.808, P = 0.001) were independent risk factors for OS. Most AEs were classified as grade 1-2, the most common being RCCEP (69.39%). There were 5 cases of grade 3-4 adverse events (10.20%). No patients discontinued or reduced the treatment dose due to AEs, and all patients received symptomatic treatment.ConclusionTACE combined with Apatinib and Camrelizumab is a safe and effective therapeutic option for patients with unresectable advanced G/GEJ cancer, which can significantly improve the median OS and ORR of patients. And the adverse events (AEs) are tolerable and manageable

Analysis the reverse conduction characteristic and influence of anti-parallel SiC SBD of eGaN HEMT

eGaN HEMT has been developed with up to 650V blocking capability with lower conduction losses and higher switching speed compared MOSFET. Self-commutated reverse conduction is a very important characteristic of eGaN HEMT, especially for synchronous rectification topologies. This paper introduces the reverse conduction mechanism and characteristics of eGaN HEMT, and establishes a double pulse test platform to explore the influence of anti-parallel SiC SBD for eGaN HEMT on the reverse conduction characteristic and switching characteristic of eGaN HEMT, which will provide some help for the application of the eGaN HEMT\u27s self-commutated reverse conduction

Crosstalk mechanism and suppression methods for enhancemen t-Mode GaN HEMTs in A phase-leg topology

It has been demonstrated that Enhancement-mode GaN HEMT(eGaN HEMT) has lower conduction losses and higher switching speed. However, higher switching speed will cause higher dVDS/dt leading to worse crosstalk problems. This paper analyzes the mechanism of crosstalk for eGaN HEMT first. Then, the mathematical model of crosstalk voltage and its influence factors are given. A double pulse test model is established and three kinds of crosstalk suppression methods without auxiliary circuit are simulated and compared. The simulation results may give a guideline for choosing which method in specific situation

A Comparative Study of Freewheeling Methods for eGaN HEMTs in a Phase-leg Configuration

Enhancement Gallium nitride high-electron mobility transistors (eGaN HEMTs) have been developed with lower conduction losses and higher switching speed compared to MOSFETs. Self-commutated reverse conduction (SCRC) mechanism determines no reverse recovery phenomenon but larger reverse conduction voltage drop of eGaN HEMTs than the body diodes in traditional Si MOSFETs or other freewheeling diodes. To reduce the large reverse conduction loss of eGaN HEMTs, the performance of different freewheeling methods for eGaN HEMTs in a phase-leg configuration is compared in this paper. Firstly, the reverse conduction mechanism and characteristics of eGaN HEMTs are analyzed. Then, four freewheeling ways for eGaN HEMTs are introduced, and the equivalent circuits are also given and analyzed. A double pulse test platform is established to further explore the influence of the freewheeling ways on the conduction and switching characteristics. Finally, the total losses of a phase-leg configuration with different freewheeling ways based on a buck converter is analyzed and compared. The paper aims to give a guidance to properly select freewheeling ways for eGaN HEMTs under different operation conditions

General deep learning framework for emissivity engineering

Abstract Wavelength-selective thermal emitters (WS-TEs) have been frequently designed to achieve desired target emissivity spectra, as a typical emissivity engineering, for broad applications such as thermal camouflage, radiative cooling, and gas sensing, etc. However, previous designs require prior knowledge of materials or structures for different applications and the designed WS-TEs usually vary from applications to applications in terms of materials and structures, thus lacking of a general design framework for emissivity engineering across different applications. Moreover, previous designs fail to tackle the simultaneous design of both materials and structures, as they either fix materials to design structures or fix structures to select suitable materials. Herein, we employ the deep Q-learning network algorithm, a reinforcement learning method based on deep learning framework, to design multilayer WS-TEs. To demonstrate the general validity, three WS-TEs are designed for various applications, including thermal camouflage, radiative cooling and gas sensing, which are then fabricated and measured. The merits of the deep Q-learning algorithm include that it can (1) offer a general design framework for WS-TEs beyond one-dimensional multilayer structures; (2) autonomously select suitable materials from a self-built material library and (3) autonomously optimize structural parameters for the target emissivity spectra. The present framework is demonstrated to be feasible and efficient in designing WS-TEs across different applications, and the design parameters are highly scalable in materials, structures, dimensions, and the target functions, offering a general framework for emissivity engineering and paving the way for efficient design of nonlinear optimization problems beyond thermal metamaterials

Facile Preparation of Ag-Coated Superhydrophobic/Superoleophilic Mesh for Efficient Oil/Water Separation with Excellent Corrosion Resistance

We present the facile preparation of a superhydrophobic–oleophilic stainless steel mesh with excellent oil/water separation efficiency and resistance to corrosion through hydrofluoric (HF) acid etching, Ag nanoparticle coating, and stearic acid modification, to construct a superhydrophobic micro/nanohierarchical structure. The surface of the treated mesh exhibits superhydrophobicity, with a water contact angle of 152°, and superoleophilicity, with an oil contact angle of 0°. The effects of variation in the HF etching time and Ag nanoparticle coating on surface wettability were explored. The treated mesh demonstrated a very high separation efficiency, as high as 98% for the optimal preparation, on a series of oil/water mixtures. The durability of the treated mesh was tested by repeated separation of kerosene/water mixtures, with the separation efficiency remaining higher than 97% after 40 cycles. In addition, the mesh exhibited an excellent chemical resistance to both acidic and alkaline conditions, with good wearing in hot water. The improved superhydrophobic–oleophilic mesh represents a feasible and realistic oil/water separation methodology even under harsh conditions, and it could have wide application in industrial processes

Facile Preparation of Ag-Coated Superhydrophobic/Superoleophilic Mesh for Efficient Oil/Water Separation with Excellent Corrosion Resistance

We present the facile preparation of a superhydrophobic–oleophilic stainless steel mesh with excellent oil/water separation efficiency and resistance to corrosion through hydrofluoric (HF) acid etching, Ag nanoparticle coating, and stearic acid modification, to construct a superhydrophobic micro/nanohierarchical structure. The surface of the treated mesh exhibits superhydrophobicity, with a water contact angle of 152°, and superoleophilicity, with an oil contact angle of 0°. The effects of variation in the HF etching time and Ag nanoparticle coating on surface wettability were explored. The treated mesh demonstrated a very high separation efficiency, as high as 98% for the optimal preparation, on a series of oil/water mixtures. The durability of the treated mesh was tested by repeated separation of kerosene/water mixtures, with the separation efficiency remaining higher than 97% after 40 cycles. In addition, the mesh exhibited an excellent chemical resistance to both acidic and alkaline conditions, with good wearing in hot water. The improved superhydrophobic–oleophilic mesh represents a feasible and realistic oil/water separation methodology even under harsh conditions, and it could have wide application in industrial processes

Facile Preparation of Ag-Coated Superhydrophobic/Superoleophilic Mesh for Efficient Oil/Water Separation with Excellent Corrosion Resistance

We present the facile preparation of a superhydrophobic–oleophilic stainless steel mesh with excellent oil/water separation efficiency and resistance to corrosion through hydrofluoric (HF) acid etching, Ag nanoparticle coating, and stearic acid modification, to construct a superhydrophobic micro/nanohierarchical structure. The surface of the treated mesh exhibits superhydrophobicity, with a water contact angle of 152°, and superoleophilicity, with an oil contact angle of 0°. The effects of variation in the HF etching time and Ag nanoparticle coating on surface wettability were explored. The treated mesh demonstrated a very high separation efficiency, as high as 98% for the optimal preparation, on a series of oil/water mixtures. The durability of the treated mesh was tested by repeated separation of kerosene/water mixtures, with the separation efficiency remaining higher than 97% after 40 cycles. In addition, the mesh exhibited an excellent chemical resistance to both acidic and alkaline conditions, with good wearing in hot water. The improved superhydrophobic–oleophilic mesh represents a feasible and realistic oil/water separation methodology even under harsh conditions, and it could have wide application in industrial processes

Facile Preparation of Ag-Coated Superhydrophobic/Superoleophilic Mesh for Efficient Oil/Water Separation with Excellent Corrosion Resistance

We present the facile preparation of a superhydrophobic–oleophilic stainless steel mesh with excellent oil/water separation efficiency and resistance to corrosion through hydrofluoric (HF) acid etching, Ag nanoparticle coating, and stearic acid modification, to construct a superhydrophobic micro/nanohierarchical structure. The surface of the treated mesh exhibits superhydrophobicity, with a water contact angle of 152°, and superoleophilicity, with an oil contact angle of 0°. The effects of variation in the HF etching time and Ag nanoparticle coating on surface wettability were explored. The treated mesh demonstrated a very high separation efficiency, as high as 98% for the optimal preparation, on a series of oil/water mixtures. The durability of the treated mesh was tested by repeated separation of kerosene/water mixtures, with the separation efficiency remaining higher than 97% after 40 cycles. In addition, the mesh exhibited an excellent chemical resistance to both acidic and alkaline conditions, with good wearing in hot water. The improved superhydrophobic–oleophilic mesh represents a feasible and realistic oil/water separation methodology even under harsh conditions, and it could have wide application in industrial processes